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公开(公告)号：US12091763B2
公开(公告)日：2024-09-17
申请号：US17836449
申请日：2022-06-09
发明人： Zhiji Han , Ruud Kortlever , Hsiang-Yun Chen , Jonas C. Peters , Theodor Agapie , Jorge A. Rosas Hernandez , Arnaud A. Thevenon
IPC分类号： C25B3/25 , C07C1/12 , C10G2/00 , C10K3/00 , C25B11/051 , C25B11/057 , C25B11/075
CPC分类号： C25B3/25 , C07C1/12 , C10G2/50 , C10K3/00 , C25B11/051 , C25B11/057 , C25B11/075
摘要： A CO2 reduction system has a cathode in contact with a catholyte. The cathode includes a selectivity-determining layer on an electron conductor. The selectivity-determining layer includes a selectivity-determining component that includes a substituted heterocycle.
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公开(公告)号：US20220112524A1
公开(公告)日：2022-04-14
申请号：US17560753
申请日：2021-12-23
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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3.发明授权公开(公告)号：US10513719B2
公开(公告)日：2019-12-24
申请号：US15094458
申请日：2016-04-08
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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公开(公告)号：US20180251903A1
公开(公告)日：2018-09-06
申请号：US15909764
申请日：2018-03-01
发明人： Chengxiang Xiang , Xinghao Zhou , Ke Sun , Ryan J. Jones , Nathan S. Lewis
摘要： A solar fuels generator includes an anolyte and a catholyte in contact with a separator. The separator is configured such that the pH of the anolyte and the pH of the catholyte are each held at a steady state pH level during operation of the solar fuels generator. The steady state pH level of the anolyte is different from the steady state pH level of the catholyte.
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公开(公告)号：US20170037441A1
公开(公告)日：2017-02-09
申请号：US15068521
申请日：2016-03-11
发明人： Frances H. Arnold , Pete Heinzelman
CPC分类号： C12P19/14 , C07K2319/35 , C12N9/2437 , C12P19/02 , C12Y302/01004 , C12Y302/01074 , C12Y302/01091
摘要： The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
摘要翻译： 本公开涉及CBH I嵌合融合多肽，编码多肽的核酸和用于产生多肽的宿主细胞。
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公开(公告)号：US09404096B2
公开(公告)日：2016-08-02
申请号：US14788365
申请日：2015-06-30
CPC分类号： C12P7/04 , C07K14/32 , C12N9/0042 , C12N9/0071 , C12N9/0077 , C12P7/06 , C12Y106/02004 , C12Y114/14001 , C12Y114/15 , C12Y114/15003 , Y02P20/52
摘要： This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable substrate with such cells.
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公开(公告)号：US09322001B2
公开(公告)日：2016-04-26
申请号：US14274709
申请日：2014-05-10
IPC分类号： C12N9/02 , C12N15/00 , C12P21/06 , C12P21/04 , C07H21/04 , C12P7/02 , C12P7/04 , C12P7/16 , C12P17/02
摘要： Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.
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公开(公告)号：US20130288324A1
公开(公告)日：2013-10-31
申请号：US13750949
申请日：2013-01-25
IPC分类号： C12P7/02
摘要： Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P450 enzyme. A preferred wild-type cytochrome P450 is cytochrome P450 BM-3. Preferred cytochrome P450 variants include those having an improved capability to hydroxylate alkanes and epoxidate alkenes comprising less than 8 carbons, and have amino acid substitutions corresponding to V78A, H236Q, and E252G of cytochrome P450 BM-3. Preferred cytochrome P450 variants also include those having an improved hydroxylation activity in solutions comprising co-solvents such as DMSO and THF, and have amino acid substitutions corresponding to T235A, R471A, E494K, and S1024E of cytochrome P450 BM-3.
摘要翻译： 提供了编码细胞色素P450变体的核酸。 细胞色素P450变体具有比相应的野生型或亲本细胞色素P450酶更高的烷烃氧化能力，烯烃氧化能力和/或较高的有机溶剂耐受性。 优选的野生型细胞色素P450是细胞色素P450 BM-3。 优选的细胞色素P450变体包括具有改善含有少于8个碳原子的烷烃和环氧化烯烃羟基化能力以及对应于细胞色素P450 BM-3的V78A，H236Q和E252G的氨基酸取代的那些变体。 优选的细胞色素P450变体还包括在包含共溶剂如DMSO和THF的溶液中具有改善的羟基化活性的那些，并且具有对应于细胞色素P450 BM-3的T235A，R471A，E494K和S1024E的氨基酸取代。
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公开(公告)号：US20020106694A1
公开(公告)日：2002-08-08
申请号：US10057552
申请日：2002-01-25
IPC分类号： G01N033/53 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： C12N15/1089 , C07K1/00 , C07K1/003 , C07K14/001 , C12N15/1034 , G06F19/16 , G06F19/18 , G06F19/22
摘要： The present invention relates to apparatus and methods for quantitative protein design and optimization.
摘要翻译： 本发明涉及用于定量蛋白质设计和优化的装置和方法。
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公开(公告)号：US11371152B2
公开(公告)日：2022-06-28
申请号：US15950150
申请日：2018-04-10
发明人： Zhiji Han , Ruud Kortlever , Hsiang-Yun Chen , Jonas C. Peters , Theodor Agapie , Jorge A. Rosas Hernandez , Arnaud A. Thevenon
IPC分类号： C25B3/25 , C10G2/00 , C07C1/12 , C10K3/00 , C25B11/051 , C25B11/057 , C25B11/075
摘要： A CO2 reduction system has a cathode in contact with a catholyte. The cathode includes a selectivity-determining layer on an electron conductor. The selectivity-determining layer includes a selectivity-determining component that includes a substituted heterocycle.
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