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    Benzothiadiazolylphenylalkylamine derivatives and methods of their use
    3.
    发明申请
    Benzothiadiazolylphenylalkylamine derivatives and methods of their use 失效
    苯并噻二唑基苯基烷基胺衍生物及其使用方法

    公开(公告)号：US20070072918A1

    公开(公告)日：2007-03-29

    申请号：US11528792

    申请日：2006-09-27

    申请人： Casey McComas ,  Puwen Zhang ,  Eugene Trybulski ,  An Vu ,  Eugene Terefenko

    发明人： Casey McComas ,  Puwen Zhang ,  Eugene Trybulski ,  An Vu ,  Eugene Terefenko

    IPC分类号： C07D275/04 ,  C07D271/12 ,  A61K31/433 ,  A61K31/425

    CPC分类号： C07D285/14

    摘要： The present invention is directed to benzothiadiazolylphenylalkylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

    摘要翻译： 本发明涉及式I的苯并噻二唑基苯基烷基胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，所述方法尤其包括血管舒缩症状（VMS） 特别是选自重度抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等的那些情况，特别是选自以下的那些病症：血管紧张素转换酶，抑制性功能障碍，性功能障碍，胃肠道和泌尿生殖系统疾病，慢性疲劳综合征，纤维瘤病综合征，神经系统疾病及其组合， 糖尿病性神经病变及其组合。

    Substituted propylamine derivatives and methods of their use
    4.
    发明申请
    Substituted propylamine derivatives and methods of their use 失效
    取代的丙胺衍生物及其使用方法

    公开(公告)号：US20070072928A1

    公开(公告)日：2007-03-29

    申请号：US11529450

    申请日：2006-09-27

    申请人： Casey McComas ,  Puwen Zhang ,  Eugene Terefenko ,  An Vu ,  Stephen Cohn

    发明人： Casey McComas ,  Puwen Zhang ,  Eugene Terefenko ,  An Vu ,  Stephen Cohn

    IPC分类号： A61K31/4184 ,  A61K31/404

    CPC分类号： C07D209/96 ,  C07D209/08 ,  C07D209/34 ,  C07D235/26 ,  C07D235/30 ,  C07D277/68

    摘要： The present invention is directed to substituted propylamine derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

    摘要翻译： 本发明涉及式I的取代丙胺衍生物：或其药学上可接受的盐，含有这些衍生物的组合物及其用于预防和治疗由单胺再摄取改善的病症的方法，其中尤其包括血管舒缩症状（VMS） 特别是那些选自重症抑郁障碍，血管舒缩症状，压力和急迫性尿失禁，纤维肌痛，疼痛等症状的那些疾病 ，糖尿病性神经病，及其组合。

    5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators
    8.
    发明申请
    5-Aryl-indan-1-ol and analogs useful as progesterone receptor modulators 审中-公开
    5-芳基 - 茚满-1-醇和可用作孕酮受体调节剂的类似物

    公开(公告)号：US20070066628A1

    公开(公告)日：2007-03-22

    申请号：US11522881

    申请日：2006-09-18

    申请人： Puwen Zhang ,  Jeffrey Kern ,  Eugene Terefenko ,  Eugene Trybulski

    发明人： Puwen Zhang ,  Jeffrey Kern ,  Eugene Terefenko ,  Eugene Trybulski

    IPC分类号： A61K31/44 ,  C07D213/63

    CPC分类号： C07D207/34 ,  C07C255/53 ,  C07D409/10

    摘要： Compounds of formula I are provided, wherein R1-R9 and n are defined herein, and pharmaceutical compositions and kits containing these compounds. Also provided are methods of inducing contraception, providing hormone replacement therapy, treating cycle-related symptoms, or treating or preventing benign or malignant neoplastic disease using the compounds of formula I or formula II, wherein R3-R5, R10, and R11 are defined herein.

    摘要翻译： 提供式I化合物，其中R 1〜R 9和n如本文所定义，以及含有这些化合物的药物组合物和试剂盒。 还提供了使用式I或式II化合物诱导避孕，提供激素替代疗法，治疗周期相关症状或治疗或预防良性或恶性肿瘤疾病的方法，其中R 3〜 本文定义的是5，R 10和R 11。