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1.发明授权1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents 失效1-芳酰基-3-吲哚基链烷酸及其衍生物可用作抗炎剂
公开(公告)号：US5436265A
公开(公告)日：1995-07-25
申请号：US152620
申请日：1993-11-12
IPC分类号： C07D209/26 , A61K31/40 , A61K31/405 , C07D209/12
CPC分类号： C07D209/26
摘要： Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##
摘要翻译： 以下所示结构的化合物是可用于治疗环氧合酶-2介导的疾病状态如炎症，疼痛和发烧的环氧合酶-2的特异性抑制剂，并且是非溃疡性的。
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2.再颁专利Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity 失效人环氧合酶-2 cDNA和环氧合酶-2活性评估公开(公告)号：USRE39696E1
公开(公告)日：2007-06-19
申请号：US09731632
申请日：2000-11-20
申请人： Wanda A. Cromlish , Brian P. Kennedy , Gary O'Neill , Philip J. Vickers , Elizabeth Wong , Joseph A. Mancini
发明人： Wanda A. Cromlish , Brian P. Kennedy , Gary O'Neill , Philip J. Vickers , Elizabeth Wong , Joseph A. Mancini
CPC分类号： C12N9/0083 , C12Q1/48 , C12Q1/61 , C12Y114/99001 , G01N33/5005 , G01N33/88 , G01N2333/90241
摘要： The invention discloses a human cyclooxygenase-2 cDNA, a human cyclooxygenase-2 and assays for preferentially and independently measuring cyclogenase-2 or cyclooxygenase-1 activity present in a given sample.
摘要翻译： 本发明公开了一种人环加氧酶-2 cDNA，人环加氧酶-2以及优选和独立地测量给定样品中存在的环化酶-2或环加氧酶-1活性的测定法。
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3.发明授权Human cyclooxygenase-2 cDNA and assays for evaluating cyclooxygenase-2 activity 失效人环氧合酶-2 cDNA和环氧合酶-2活性评估
公开(公告)号：US5543297A
公开(公告)日：1996-08-06
申请号：US64271
申请日：1993-05-06
申请人： Wanda A. Cromlish , Brian P. Kennedy , Gary O'Neill , Philip J. Vickers , Elizabeth Wong , Joseph A. Mancini
发明人： Wanda A. Cromlish , Brian P. Kennedy , Gary O'Neill , Philip J. Vickers , Elizabeth Wong , Joseph A. Mancini
IPC分类号： C12N15/09 , C12N5/10 , C12N9/02 , C12Q1/26 , C12Q1/48 , C12Q1/61 , G01N33/50 , G01N33/88 , C07H21/04 , C12N5/06
CPC分类号： C12N9/0083 , C12Q1/48 , C12Q1/61 , C12Y114/99001 , G01N33/5005 , G01N33/88 , G01N2333/90241
摘要： The invention discloses a human cyclooxygenase-2 cDNA, a human cyclooxygenase-2 and assays for preferentially and independently measuring cyclogenase-2 or cyclooxygenase-1 activity present in a given sample.
摘要翻译： 本发明公开了一种人环加氧酶-2 cDNA，人环加氧酶-2以及优选和独立地测量给定样品中存在的环化酶-2或环加氧酶-1活性的测定法。
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4.发明授权Peptide sequences and antipeptide antisera for detecting human cyclooxygenase-1 and cyclooxygenase-2 proteins 失效用于检测人类环氧合酶-1和环加氧酶-2蛋白的肽序列和抗肽抗血清
公开(公告)号：US5459239A
公开(公告)日：1995-10-17
申请号：US186364
申请日：1994-01-24
CPC分类号： C12N9/0069 , C07K2319/00 , C12N2799/023 , Y10S530/812
摘要： This invention discloses novel immunogenic peptide sequences, derived from the human cyclooxygenase-1 and cyclooxygenase-2 cDNAs which elicit specific non cross-reactive antibody responses. Assays are also disclosed for selectively and independently detecting cyclooxygenase-1 or cyclooxygenase-2 proteins present in a given biological sample.
摘要翻译： 本发明公开了衍生自引发特异性非交叉反应性抗体应答的人环加氧酶-1和环加氧酶-2 cDNA的新型免疫原性肽序列。 还公开了用于选择性和独立地检测给定生物样品中存在的环加氧酶-1或环加氧酶-2蛋白的测定。
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