摘要:
Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
摘要:
This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or another reducing agent comprising: (i) an R1R2AlH moiety, wherein R1 and R2 are each an alkyl species or oxygen, and wherein at least one of R1 or R2 comprises at least 2 carbon atoms, or (ii) an R1R2R3Al moiety, wherein R1, R2, and R3 are not hydrogen, and wherein at least one of R1, R2, and R3 is an alkyl species comprising a β-hydrogen, not including triethylaluminum. Preferred reducing agents for the present invention include: diisobutylaluminum hydride, triisobutyldialiuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, and combinations thereof.
摘要翻译:本发明提供了一种在还原剂如氢化二异丁基铝(DIBAL-H),三异丁基二铝氧烷,三异丁基铝,四异丁基二铝氧烷或其它还原剂存在下由仲膦氧化物产生仲膦的方法,其包括:(i)R 其中R 1和R 2各自为烷基或氧,并且其中至少 R 1或R 2中的一个包含至少2个碳原子,或(ii)R 1 R 2 R 2 其中R 1,R 2和R 3不是氢,并且其中R 1,R 2,R 3和R 3不是氢,并且其中R 1, R 1,R 2和R 3 3中的至少一个是包含不包括三乙基铝的β-氢的烷基物质。 用于本发明的优选的还原剂包括:二异丁基氢化铝,三异丁基二肟氧烷,三异丁基铝,四异丁基二铝氧烷及其组合。
摘要:
This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or another reducing agent comprising: (i) an R1R2AlH moiety, wherein R1 and R2 are each an alkyl species or oxygen, and wherein at least one of R1 or R2 comprises at least 2 carbon atoms, or (ii) an R1R2R3Al moiety, wherein R1, R2, and R3 are not hydrogen, and wherein at least one of R1, R2, and R3 is an alkyl species comprising a β-hydrogen, not including triethylaluminum. Preferred reducing agents for the present invention include: diisobutylaluminum hydride, triisobutyldialiuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, and combinations thereof.
摘要翻译:本发明提供了一种在还原剂如氢化二异丁基铝(DIBAL-H),三异丁基二铝氧烷,三异丁基铝,四异丁基二铝氧烷或其它还原剂存在下由仲膦氧化物产生仲膦的方法,其包括:(i)R 其中R 1和R 2各自为烷基或氧,并且其中至少 R 1或R 2中的一个包含至少2个碳原子,或(ii)R 1 R 2 R 2 其中R 1,R 2和R 3不是氢,并且其中R 1,R 2,R 3和R 3不是氢,并且其中R 1, R 1,R 2和R 3 3中的至少一个是包含不包括三乙基铝的β-氢的烷基物质。 用于本发明的优选的还原剂包括:二异丁基氢化铝,三异丁基二肟氧烷,三异丁基铝,四异丁基二铝氧烷及其组合。
摘要:
Dihydrate and anhydrous crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2′,3′-e] [1,4]diazepin-6-one.
摘要:
User device information, identifying a first plurality of devices associated with a first user, is stored. A first device of the first plurality of devices is identified as being active. Data pertaining to an interaction session, within which the first user is participating, is provided to the first device based on the determination that the first device is active.
摘要:
In some example embodiments, a system and method is shown that includes receiving selection input to select content to be presented by a device. A presentation option is selected for a presentation of the content based upon a content type of the content and a presentation attribute.
摘要:
A network device is determined to be within a determinable proximity of a physical structure. Data pertaining to an interaction session is provided to the network device, via a network, based on the determination, the interaction session being between a number of network devices within the determinable proximity of the physical structure.
摘要:
Apparatus, systems, and methods may operate to receive an electronic document and an associated document profile at a client. The client may then open the electronic document using a software application and configure the software application using the associated document profile. Additional apparatus, systems, and methods are disclosed.
摘要:
Apparatus, systems, and methods may operate to receive a symbol recognition process gesture indicating a starting point of symbol entry, to recognize a series of symbols as they are received subsequent to receiving the symbol recognition process gesture, and to instantiate the series of symbols as a symbol set upon receiving an indication that reception of the series of symbols is complete. Instantiating can serve to indicate an ending point of the symbol entry, and to provide the symbol set as a source of input to a process associated with an icon into which the symbol set has been moved, such as by dragging and dropping, or flicking. Additional apparatus, systems, and methods are disclosed.