公开(公告)号：US08323336B2

公开(公告)日：2012-12-04

申请号：US12429054

申请日：2009-04-23

申请人： Alexander J. Hill ,  Cynthia T. Clague ,  Carol Elsa Eberhardt ,  Ana R. Menk ,  Mark J. Capps ,  Billie J. Millwee ,  Janice Lynn Shay ,  Debra Ann Taitague ,  Joseph C. Morrow ,  Jerald Redmond

发明人： Alexander J. Hill ,  Cynthia T. Clague ,  Carol Elsa Eberhardt ,  Ana R. Menk ,  Mark J. Capps ,  Billie J. Millwee ,  Janice Lynn Shay ,  Debra Ann Taitague ,  Joseph C. Morrow ,  Jerald Redmond

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/24 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2463 ,  A61F2/2487 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0045 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2250/0039

摘要： A stented valve of two or more leaflets made of pericardium or other material having a relatively thin profile at the annulus. The leaflet surfaces are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.

摘要翻译： 由心包或其他材料制成的两个或更多个传单的支架瓣膜，在瓣环处具有较薄的轮廓。 小叶表面通过和弦连接到支架框架上，其中和弦被定位成模拟天然瓣膜解剖结构和功能。 特别地，本发明的一个示例性实施例的阀的尺寸被设计成代替二尖瓣，并且因此设置弦杆以防止小叶向中庭脱垂。 由于和弦的定位，支架瓣膜在其环形处具有相对短的高度。 此外，支架瓣膜能够被卷曲到足够小的尺寸，使得其可以经由经导管递送系统和方法递送到植入部位。

公开(公告)号：US08075615B2

公开(公告)日：2011-12-13

申请号：US11729680

申请日：2007-03-28

申请人： Carol Elsa Eberhardt ,  Janice Lynn Shay

发明人： Carol Elsa Eberhardt ,  Janice Lynn Shay

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2310/00011 ,  H01M4/131 ,  H01M4/485 ,  H01M4/5825 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0566 ,  Y02E60/122 ,  Y02P70/54

摘要： A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.

摘要翻译： 一种假体支架式心脏瓣膜，其包括具有第一和第二相对端部的可压缩且可扩张的支架结构，扩张的外周边，以及当经受外部径向力时至少稍小于所述扩张的外周边的压缩外周边。 该阀还包括阀段，该阀段包括形成为具有至少一个纵向延伸的接缝的大体管状形状的双层片，以及通过将双层片的外层附接到 单页中的双层纸定义图案。 阀段至少部分地定位在支架结构内。 所述阀还可包括与所述支架结构的所述第一和第二端部间隔开的所述双层片材的外层中的至少一个开口。

公开(公告)号：US20090281618A1

公开(公告)日：2009-11-12

申请号：US12429054

申请日：2009-04-23

申请人： Alexander J. Hill ,  Cynthia Clague ,  Carol Elsa Eberhardt ,  Ana R. Menk ,  Mark J. Capps ,  Billie J. Millwee ,  Janice Lynn Shay ,  Debra Ann Taitague ,  Joseph C. Morrow ,  Jerald Redmond

发明人： Alexander J. Hill ,  Cynthia Clague ,  Carol Elsa Eberhardt ,  Ana R. Menk ,  Mark J. Capps ,  Billie J. Millwee ,  Janice Lynn Shay ,  Debra Ann Taitague ,  Joseph C. Morrow ,  Jerald Redmond

IPC分类号： A61F2/06

CPC分类号： A61F2/2412 ,  A61F2/24 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2/2454 ,  A61F2/2457 ,  A61F2/2463 ,  A61F2/2487 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/0045 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/0076 ,  A61F2230/008 ,  A61F2250/0039

摘要： A stented valve of two or more leaflets made of pericardium or other material having a relatively thin profile at the annulus. The leaflet surfaces are attached via chords to a stent frame, where the chords are positioned to mimic the native valve anatomy and functionality. In particular, the valves of one exemplary embodiment of the invention are sized to replace a mitral valve and therefore the chords are arranged to prevent prolapse of the leaflets into the atrium. The stented valve has a relatively short height at its annulus due to the positioning of the chords. In addition, the stented valve is capable of being crimped to a small enough size that it can be delivered to the implantation site via transcatheter delivery systems and methods.

摘要翻译： 由心包或其他材料制成的两个或更多个传单的支架瓣膜，在瓣环处具有较薄的轮廓。 小叶表面通过和弦连接到支架框架上，其中和弦被定位成模拟天然瓣膜解剖结构和功能。 特别地，本发明的一个示例性实施例的阀的尺寸被设计成代替二尖瓣，并且因此设置弦杆以防止小叶向中庭脱垂。 由于和弦的定位，支架瓣膜在其环形处具有相对短的高度。 此外，支架瓣膜能够被卷曲到足够小的尺寸，使得其可以经由经导管递送系统和方法递送到植入部位。

公开(公告)号：US20070233228A1

公开(公告)日：2007-10-04

申请号：US11729680

申请日：2007-03-28

申请人： Carol Elsa Eberhardt ,  Janice Lynn Shay

发明人： Carol Elsa Eberhardt ,  Janice Lynn Shay

IPC分类号： A61F2/06

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2310/00011 ,  H01M4/131 ,  H01M4/485 ,  H01M4/5825 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0566 ,  Y02E60/122 ,  Y02P70/54

摘要： A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.

摘要翻译： 一种假体支架式心脏瓣膜，其包括具有第一和第二相对端部的可压缩且可扩张的支架结构，扩张的外周边，以及当经受外部径向力时至少稍小于所述扩张的外周边的压缩外周边。 该阀还包括阀段，该阀段包括形成为具有至少一个纵向延伸的接缝的大体管状形状的双层片，以及通过将双层片的外层附接到 单页中的双层纸定义图案。 阀段至少部分地定位在支架结构内。 所述阀还可包括与所述支架结构的所述第一和第二端部间隔开的所述双层片材的外层中的至少一个开口。

公开(公告)号：US09331328B2

公开(公告)日：2016-05-03

申请号：US13316885

申请日：2011-12-12

申请人： Carol Elsa Eberhardt ,  Janice Lynn Shay

发明人： Carol Elsa Eberhardt ,  Janice Lynn Shay

IPC分类号： A61F2/24 ,  H01M4/131 ,  H01M4/485 ,  H01M4/58 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0566

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2310/00011 ,  H01M4/131 ,  H01M4/485 ,  H01M4/5825 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0566 ,  Y02E60/122 ,  Y02P70/54

摘要： A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.

摘要翻译： 一种假体支架式心脏瓣膜，其包括具有第一和第二相对端部的可压缩且可扩张的支架结构，扩张的外周边，以及当经受外部径向力时至少稍小于所述扩张的外周边的压缩外周边。 该阀还包括阀段，该阀段包括形成为具有至少一个纵向延伸的接缝的大体管状形状的双层片，以及通过将双层片的外层附接到 单页中的双层纸定义图案。 阀段至少部分地定位在支架结构内。 所述阀还可包括与所述支架结构的所述第一和第二端部间隔开的所述双层片材的外层中的至少一个开口。

公开(公告)号：US20120083879A1

公开(公告)日：2012-04-05

申请号：US13316885

申请日：2011-12-12

申请人： Carol Elsa Eberhardt ,  Janice Lynn Shay

发明人： Carol Elsa Eberhardt ,  Janice Lynn Shay

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2415 ,  A61F2210/0076 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2310/00011 ,  H01M4/131 ,  H01M4/485 ,  H01M4/5825 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0566 ,  Y02E60/122 ,  Y02P70/54

摘要： A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.

摘要翻译： 一种假体支架式心脏瓣膜，其包括具有第一和第二相对端部的可压缩且可扩张的支架结构，扩张的外周边，以及当经受外部径向力时至少稍小于所述扩张的外周边的压缩外周边。 该阀还包括阀段，该阀段包括形成为具有至少一个纵向延伸的接缝的大体管状形状的双层片，以及通过将双层片的外层附接到 单页中的双层纸定义图案。 阀段至少部分地定位在支架结构内。 所述阀还可包括与所述支架结构的所述第一和第二端部间隔开的所述双层片材的外层中的至少一个开口。