公开(公告)号：US20070203223A1

公开(公告)日：2007-08-30

申请号：US11702425

申请日：2007-02-05

Applicant: Craig Siegel ,  James Shayman ,  Carol Nelson ,  David Harris ,  Diane Copeland

Inventor： Craig Siegel ,  James Shayman ,  Carol Nelson ,  David Harris ,  Diane Copeland

IPC: A61K31/4025

CPC classification number: C07D405/06 ,  A61K31/4025 ,  C07D295/185 ,  C07D319/18 ,  C07D498/04

Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

Abstract translation: 公开了UDP-葡萄糖：N-酰基鞘氨醇葡糖基转移酶的新型对映体合成神经酰胺样抑制剂。 还公开了在合成过程中形成的新型中间体。

公开(公告)号：USD305603S

公开(公告)日：1990-01-23

申请号：US87625

申请日：1987-08-20

Applicant: Donald Nelson ,  Carol Nelson

Designer： Donald Nelson ,  Carol Nelson

公开(公告)号：US20160193495A1

公开(公告)日：2016-07-07

申请号：US14952554

申请日：2015-11-25

Applicant: Carol Nelson

Inventor： Carol Nelson

IPC: A63B21/00 ,  A61B5/11 ,  A63B23/12 ,  A63B23/025 ,  A63B21/06 ,  A63B21/16

CPC classification number: A63B21/159 ,  A61B5/1121 ,  A61B5/6822 ,  A61H1/0281 ,  A61H2201/0123 ,  A61H2201/0126 ,  A61H2201/0192 ,  A61H2201/1261 ,  A61H2201/1269 ,  A61H2201/1633 ,  A61H2201/1635 ,  A61H2201/1638 ,  A61H2201/164 ,  A61H2201/1642 ,  A61H2201/1676 ,  A61H2203/0431 ,  A63B21/00069 ,  A63B21/015 ,  A63B21/06 ,  A63B21/16 ,  A63B21/1645 ,  A63B21/169 ,  A63B21/4017 ,  A63B21/4035 ,  A63B21/4047 ,  A63B23/025 ,  A63B23/03508 ,  A63B23/1209 ,  A63B23/1245 ,  A63B2071/0694 ,  A63B2220/16 ,  A63B2225/09 ,  A63B2225/093

Abstract: A physical therapy device comprising a frame; a body attachable to said frame; an arm attached to said body and arranged to rotate with respect to said body about a pivot axis. The body is repositionable between first and second orientations, in said second orientation said pivot axis oriented non-parallel to its position in said first orientation.

Abstract translation: 一种物理治疗装置，包括框架; 可附接到所述框架的主体; 臂连接到所述主体并布置成相对于所述主体围绕枢转轴线旋转。 主体可在第一和第二取向之间重新定位，在所述第二方位中，所述枢转轴线定向为不平行于其在所述第一方向上的位置。

公开(公告)号：US20050222244A1

公开(公告)日：2005-10-06

申请号：US11091836

申请日：2005-03-28

Applicant: Craig Siegel ,  James Shayman ,  Carol Nelson ,  David Harris ,  Diane Copeland

Inventor： Craig Siegel ,  James Shayman ,  Carol Nelson ,  David Harris ,  Diane Copeland

IPC: C07D295/12 ,  A61K31/40 ,  A61K31/4025 ,  A61P1/16 ,  A61P7/06 ,  A61P17/02 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  A61P43/00 ,  C07B53/00 ,  C07B61/00 ,  C07D295/18 ,  C07D295/185 ,  C07D319/18 ,  C07D498/04 ,  C07D45/02

CPC classification number: C07D405/06 ,  A61K31/4025 ,  C07D295/185 ,  C07D319/18 ,  C07D498/04

Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.

Abstract translation: 公开了UDP-葡萄糖：N-酰基鞘氨醇葡糖基转移酶的新型对映体合成神经酰胺样抑制剂。 还公开了在合成过程中形成的新型中间体。

公开(公告)号：US09999561B2

公开(公告)日：2018-06-19

申请号：US15840423

申请日：2017-12-13

Applicant: Carol Nelson

Inventor： Carol Nelson

IPC: A63B23/00 ,  A61H1/02 ,  A61B5/11

CPC classification number: A61H1/024 ,  A61B5/11 ,  A61B5/1121 ,  A61B5/6822 ,  A61H1/0281 ,  A61H2201/0123 ,  A61H2201/0126 ,  A61H2201/0192 ,  A61H2201/1253 ,  A61H2201/1261 ,  A61H2201/1269 ,  A61H2201/1633 ,  A61H2201/1635 ,  A61H2201/1638 ,  A61H2201/164 ,  A61H2201/1642 ,  A61H2201/1676 ,  A61H2203/0431 ,  A61H2205/062 ,  A61H2205/104 ,  A63B21/00069 ,  A63B21/015 ,  A63B21/159 ,  A63B21/16 ,  A63B21/1645 ,  A63B21/169 ,  A63B21/4017 ,  A63B21/4035 ,  A63B21/4047 ,  A63B23/025 ,  A63B23/03508 ,  A63B23/1209 ,  A63B23/1245 ,  A63B2071/0694 ,  A63B2220/16 ,  A63B2225/09 ,  A63B2225/093

Abstract: A physical therapy device comprising a bench, having a seating surface and legs and a pair of horizontal supports positioned to either side of the knees of a person seated on the bench, a quick release securing device connected to each of the pair of supports, a rail connected to one of the quick release securing devices, a body pivotally attached to said rail, a foot rest attached to said rail and the foot rest and rail arranged to rotate with respect to said body about a pivot axis, the body having an adjustment mechanism to adjust the amount of force required to rotate the rail with respect to the body, wherein said body is repositionable between first and second positions, to provide physical therapy to the knee.

公开(公告)号：US20180098905A1

公开(公告)日：2018-04-12

申请号：US15840423

申请日：2017-12-13

Applicant: Carol Nelson

Inventor： Carol Nelson

IPC: A61H1/02 ,  A61B5/11

CPC classification number: A61H1/024 ,  A61B5/11 ,  A61B5/1121 ,  A61B5/6822 ,  A61H1/0281 ,  A61H2201/0123 ,  A61H2201/0126 ,  A61H2201/0192 ,  A61H2201/1253 ,  A61H2201/1261 ,  A61H2201/1269 ,  A61H2201/1633 ,  A61H2201/1635 ,  A61H2201/1638 ,  A61H2201/164 ,  A61H2201/1642 ,  A61H2201/1676 ,  A61H2203/0431 ,  A61H2205/062 ,  A61H2205/104 ,  A63B21/00069 ,  A63B21/015 ,  A63B21/159 ,  A63B21/16 ,  A63B21/1645 ,  A63B21/169 ,  A63B21/4017 ,  A63B21/4035 ,  A63B21/4047 ,  A63B23/025 ,  A63B23/03508 ,  A63B23/1209 ,  A63B23/1245 ,  A63B2071/0694 ,  A63B2220/16 ,  A63B2225/09 ,  A63B2225/093

Abstract: A physical therapy device comprising a bench, having a seating surface and legs and a pair of horizontal supports positioned to either side of the knees of a person seated on the bench, a quick release securing device connected to each of the pair of supports, a rail connected to one of the quick release securing devices, a body pivotally attached to said rail, a foot rest attached to said rail and the foot rest and rail arranged to rotate with respect to said body about a pivot axis, the body having an adjustment mechanism to adjust the amount of force required to rotate the rail with respect to the body, wherein said body is repositionable between first and second positions, to provide physical therapy to the knee.

公开(公告)号：US20050267094A1

公开(公告)日：2005-12-01

申请号：US11119541

申请日：2005-04-29

Applicant: James Shayman ,  David Harris ,  Craig Siegel ,  Carol Nelson ,  Diane Copeland

Inventor： James Shayman ,  David Harris ,  Craig Siegel ,  Carol Nelson ,  Diane Copeland

IPC: A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/451 ,  A61K31/5377 ,  C07D295/13 ,  C07D317/54 ,  C07D319/18 ,  C07D321/10 ,  C07D413/02

CPC classification number: A61K31/397 ,  A61K31/40 ,  A61K31/445 ,  A61K31/498 ,  A61K31/5375 ,  C07D295/13 ,  C07D317/54 ,  C07D319/18 ,  C07D321/10 ,  Y02A50/473

Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.