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公开(公告)号：US20180133304A1
公开(公告)日：2018-05-17
申请号：US15589677
申请日：2017-05-08
IPC分类号： A61K39/12 , A61P35/00 , A61P35/04 , A61K31/704
CPC分类号： A61K39/12 , A61K31/704 , A61K2039/5258 , A61K2039/544 , A61K2039/585 , A61P35/00 , A61P35/04 , C12N7/00 , C12N2770/00023 , C12N2770/00034 , C12N2770/00071 , C12N2770/32022 , C12N2770/32023 , C12N2770/32034 , C12N2770/32071
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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2.发明申请METHOD FOR PREPARING VIRUS-LIKE PARTICLE AND RECOMBINANT BACULOVIRUS USED THEREIN 有权用于制备病毒样颗粒的方法和用于其的重组细菌公开(公告)号：US20150093804A1
公开(公告)日：2015-04-02
申请号：US14564512
申请日：2014-12-09
发明人： YU-CHEN HU , SHIH-YEH LIN
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C12N9/506 , C12N2710/14143 , C12N2770/32023 , C12N2770/32062 , C12N2770/32323 , C12N2770/32351
摘要： A recombinant baculovirus is provided for preparing picornavirus virus-like particles (VLP), wherein Chitinase A (ChiA) and Cathepsin V (v-cath) genes of the recombinant baculovirus are functionally disrupted and the recombinant baculovirus includes a picornavirus capsid protein gene under control of a strong promoter, and includes a protease gene configured for encoding a protease for hydrolyzing the capsid protein under control of a weak promoter. The recombinant baculovirus of the present invention may adopt High Five or Sf-9 cells for manufacturing enterovirus virus-like particles with improved stability and higher yields in comparison with the conventional arts. A method for preparing virus like particles is also herein provided.
摘要翻译： 提供重组杆状病毒用于制备微小RNA病毒病毒样颗粒（VLP），其中重组杆状病毒的几丁质酶A（ChiA）和组织蛋白酶V（v-cath）基因在功能上被破坏，并且重组杆状病毒包括控制下的微小RNA病毒衣壳蛋白基因 的强启动子，并且包括配置用于编码用于在弱启动子控制下水解衣壳蛋白的蛋白酶的蛋白酶基因。 与传统技术相比，本发明的重组杆状病毒可以采用High Five或Sf-9细胞来制造具有改进的稳定性和更高产量的肠病毒病毒样颗粒。 本文还提供了制备病毒颗粒的方法。
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公开(公告)号：US11883505B2
公开(公告)日：2024-01-30
申请号：US16854444
申请日：2020-04-21
CPC分类号： A61K47/6901 , A61K9/0019 , A61K9/5184 , A61K31/555 , A61K39/12 , A61P35/00 , A61K2039/585 , C12N2750/12022 , C12N2750/12023 , C12N2770/00034 , C12N2770/00042 , C12N2770/32022 , C12N2770/32023
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
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公开(公告)号：US11730803B2
公开(公告)日：2023-08-22
申请号：US17680813
申请日：2022-02-25
IPC分类号： A61K39/125 , C12N7/00 , A61P35/04 , A61K39/12 , A61P35/00 , A61K31/704 , A61K39/00
CPC分类号： A61K39/12 , A61K31/704 , A61P35/00 , A61P35/04 , C12N7/00 , A61K2039/5258 , A61K2039/544 , A61K2039/585 , C12N2770/00023 , C12N2770/00034 , C12N2770/00071 , C12N2770/32022 , C12N2770/32023 , C12N2770/32034 , C12N2770/32071
摘要： A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
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公开(公告)号：US20240285792A1
公开(公告)日：2024-08-29
申请号：US18426706
申请日：2024-01-30
CPC分类号： A61K47/6901 , A61K9/0019 , A61K9/5184 , A61K31/555 , A61K39/12 , A61P35/00 , A61K2039/585 , C12N2750/12022 , C12N2750/12023 , C12N2770/00034 , C12N2770/00042 , C12N2770/32022 , C12N2770/32023
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
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公开(公告)号：US20230174952A1
公开(公告)日：2023-06-08
申请号：US17868144
申请日：2022-07-19
发明人： Jonathan Pokorski , Nicole Steinmetz , Parker Lee
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12Y301/27005 , C12N2770/18051 , C12N2770/32023 , C12N2770/18023 , C12N2770/32051
摘要： A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
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公开(公告)号：US20130252311A1
公开(公告)日：2013-09-26
申请号：US13600543
申请日：2012-08-31
申请人： YU-CHEN HU , SHIH-YEH LIN
发明人： YU-CHEN HU , SHIH-YEH LIN
IPC分类号： C12N7/01
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C12N9/506 , C12N2710/14143 , C12N2770/32023 , C12N2770/32062 , C12N2770/32323 , C12N2770/32351
摘要： A recombinant baculovirus is provided for preparing picornavirus virus-like particles (VLP), wherein Chitinase A (ChiA) and Cathepsin V (v-cath) genes of the recombinant baculovirus are functionally disrupted and the recombinant baculovirus includes a picornavirus capsid protein gene under control of a strong promoter, and includes a protease gene configured for encoding a protease for hydrolyzing the capsid protein under control of a weak promoter. The recombinant baculovirus of the present invention may adopt High Five or Sf-9 cells for manufacturing enterovirus virus-like particles with improved stability and higher yields in comparison with the conventional arts. A method for preparing virus like particles is also herein provided.
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公开(公告)号：US20240285793A1
公开(公告)日：2024-08-29
申请号：US18657338
申请日：2024-05-07
发明人： Nicole F. Steinmetz
CPC分类号： A61K47/6901 , A61K9/0019 , A61K9/5184 , A61K31/555 , A61K39/12 , A61P35/00 , A61K2039/585 , C12N2750/12022 , C12N2750/12023 , C12N2770/00034 , C12N2770/00042 , C12N2770/32022 , C12N2770/32023
摘要： A method of treating cancer in a subject that includes administering to the cancer a therapeutically effective amount of an anti-cancer virus particle, the virus particle including a rod-shaped plant virus or virus-like particle and mitoxantrone (MTO) or analogs thereof, wherein the MTO is loaded into the interior channel of the rod-shaped plant virus particle.
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公开(公告)号：US11946075B2
公开(公告)日：2024-04-02
申请号：US17868144
申请日：2022-07-19
发明人： Jonathan Pokorski , Nicole Steinmetz , Parker Lee
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2770/18023 , C12N2770/18051 , C12N2770/32023 , C12N2770/32051 , C12Y301/27005
摘要： A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
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10.发明授权Method for preparing virus-like particle and recombinant baculovirus used therein 有权用于制备病毒样颗粒和重组杆状病毒的方法公开(公告)号：US09388390B2
公开(公告)日：2016-07-12
申请号：US14564512
申请日：2014-12-09
发明人： Yu-Chen Hu , Shih-Yeh Lin
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5258 , C12N9/506 , C12N2710/14143 , C12N2770/32023 , C12N2770/32062 , C12N2770/32323 , C12N2770/32351
摘要： A recombinant baculovirus is provided for preparing picornavirus virus-like particles (VLP), wherein Chitinase A (ChiA) and Cathepsin V (v-cath) genes of the recombinant baculovirus are functionally disrupted and the recombinant baculovirus includes a picornavirus capsid protein gene under control of a strong promoter, and includes a protease gene configured for encoding a protease for hydrolyzing the capsid protein under control of a weak promoter. The recombinant baculovirus of the present invention may adopt High Five or Sf-9 cells for manufacturing enterovirus virus-like particles with improved stability and higher yields in comparison with the conventional arts. A method for preparing virus like particles is also herein provided.
摘要翻译： 提供重组杆状病毒用于制备微小RNA病毒病毒样颗粒（VLP），其中重组杆状病毒的几丁质酶A（ChiA）和组织蛋白酶V（v-cath）基因在功能上被破坏，并且重组杆状病毒包括控制下的微小RNA病毒衣壳蛋白基因 的强启动子，并且包括配置用于编码用于在弱启动子控制下水解衣壳蛋白的蛋白酶的蛋白酶基因。 与传统技术相比，本发明的重组杆状病毒可以采用High Five或Sf-9细胞来制造具有改进的稳定性和更高产量的肠病毒病毒样颗粒。 本文还提供了制备病毒颗粒的方法。
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