公开(公告)号：US11191871B2

公开(公告)日：2021-12-07

申请号：US16371806

申请日：2019-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61L27/24 ,  A61K9/50 ,  A61K47/02 ,  A61K47/42 ,  C07K14/78 ,  A61L27/54 ,  C12N5/00 ,  A61L27/36 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/075

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20220088268A1

公开(公告)日：2022-03-24

申请号：US17544544

申请日：2021-12-07

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61L27/24 ,  C07K14/78 ,  A61L27/54 ,  C12N5/00 ,  A61L27/36 ,  A61K9/50 ,  A61K47/02 ,  A61K47/42

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20190298656A1

公开(公告)日：2019-10-03

申请号：US16371806

申请日：2019-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61K9/50 ,  A61K47/02 ,  A61K47/42

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US11944716B2

公开(公告)日：2024-04-02

申请号：US17544544

申请日：2021-12-07

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61K9/50 ,  A61K47/02 ,  A61K47/42 ,  A61L27/24 ,  A61L27/36 ,  A61L27/54 ,  C07K14/78 ,  C12N5/00 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/075

CPC classification number: A61L27/24 ,  A61K9/50 ,  A61K9/5084 ,  A61K47/02 ,  A61K47/42 ,  A61L27/36 ,  A61L27/54 ,  C07K14/78 ,  C12N5/0068 ,  A61K9/501 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/075 ,  C08J2389/00 ,  C12N2533/54

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20190298883A1

公开(公告)日：2019-10-03

申请号：US16371781

申请日：2019-04-01

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61L27/24 ,  C07K14/78 ,  A61L27/36 ,  A61L27/54 ,  C12N5/00

Abstract: A method of forming an insoluble native collagen fiber additive, includes soaking the decellularized tissue powder, which includes collagen fibers, in acidic or basic, salt solution, enzymatically dissociating the insoluble collagen fibers, and isolating insoluble native collagen fibers from the solution. The isolated insoluble collagen fibers can be used in cell aggregates and/or tissue constructs to provide three dimensional cell growth and/or adhesion.