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    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MONITORED APPLICATION OF MECHANICAL FORCE TO SAMPLES USING ACOUSTIC ENERGY AND MECHANICAL PARAMETER VALUE EXTRACTION USING MECHANICAL RESPONSE MODELS
    1.
    发明申请
    METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR MONITORED APPLICATION OF MECHANICAL FORCE TO SAMPLES USING ACOUSTIC ENERGY AND MECHANICAL PARAMETER VALUE EXTRACTION USING MECHANICAL RESPONSE MODELS 有权
    方法，系统和计算机可读介质使用机械能量和机械参数值提取使用机械响应模型监测机械力对样品的应用

    公开(公告)号：US20100138163A1

    公开(公告)日：2010-06-03

    申请号：US12607986

    申请日：2009-10-28

    申请人： Caterina Gallippi ,  Olgha Davis ,  F. William Mauldin, JR. ,  Elizabeth Loboa ,  Mansoor Haider

    发明人： Caterina Gallippi ,  Olgha Davis ,  F. William Mauldin, JR. ,  Elizabeth Loboa ,  Mansoor Haider

    IPC分类号： G06G7/48 ,  G06F19/00 ,  G01N33/48

    CPC分类号： G01N29/045 ,  A61B8/08 ,  A61B8/485 ,  G01N29/0654 ,  G01N29/343 ,  G01N2291/02475 ,  G01N2291/02827

    摘要： The subject matter described herein includes methods, systems, and computer readable media for monitored application of mechanical force to samples using acoustic energy and mechanical parameter value extraction using mechanical response models. One aspect of the subject matter described herein includes a method for determining mechanical property parameters of a sample. The method includes applying acoustic energy to a sample to apply a mechanical force to the sample. The method further includes measuring a response by the sample during the application of the acoustic energy to determine a value for a first mechanical property parameter of the sample. The method further includes measuring a recovery response of the sample following cessation of the application of the acoustic energy to determine a value for at least one second mechanical property parameter of the sample. The method further includes determining a value for at least one additional mechanical property parameter of the sample based on a mathematical relationship between the first, at least one second, and at least one additional mechanical property parameter.

    摘要翻译： 本文描述的主题包括用于使用声能和使用机械响应模型的机械参数值提取来监测对样本应用机械力的方法，系统和计算机可读介质。 本文所述的主题的一个方面包括用于确定样品的机械性能参数的方法。 该方法包括向样品施加声能以对样品施加机械力。 该方法还包括在施加声能期间测量样品的响应，以确定样品的第一机械性能参数的值。 该方法还包括在停止施加声能之后测量样品的恢复响应，以确定样品的至少一个第二机械性质参数的值。 该方法还包括基于第一，至少一个第二和至少一个附加机械性能参数之间的数学关系来确定样品的至少一个额外的机械性质参数的值。

    SINGULAR VALUE FILTER FOR IMAGING OR DETECTION
    2.
    发明申请
    SINGULAR VALUE FILTER FOR IMAGING OR DETECTION 有权
    用于成像或检测的单值过滤器

    公开(公告)号：US20130094729A1

    公开(公告)日：2013-04-18

    申请号：US13650821

    申请日：2012-10-12

    申请人： F. William Mauldin, JR. ,  John A, Hossack ,  Abhay V. Patil

    发明人： F. William Mauldin, JR. ,  John A, Hossack ,  Abhay V. Patil

    IPC分类号： G06K9/40 ,  B06B1/06

    CPC分类号： G06K9/6247 ,  A61B8/0891 ,  A61B8/481 ,  A61B8/485 ,  A61B8/5207 ,  G01S7/52039 ,  G01S7/52041 ,  G01S7/52042 ,  G01S7/52046 ,  G01S15/8915 ,  G01S15/8981

    摘要： Apparatus or techniques can include obtaining information indicative of energy, such as ultrasonic energy, reflected from a tissue region, forming respective input matrices representative of the obtained information, the input matrices respectively comprising an ensemble-of-interest and at least one ensemble corresponding to a spatial location nearby a spatial location corresponding to the ensemble-of-interest, performing respective singular value decompositions on the respective input matrices to obtain respective sets of singular values corresponding to respective sets of singular vectors, obtaining respective output matrices including weighting a respective projection of a respective ensemble-of-interest onto at least one of the singular vectors included in a respective set of singular vectors, and, using the respective output matrices, at least one of determining a characteristic, or constructing an image, of at least a portion of the tissue region.

    摘要翻译： 设备或技术可以包括获得指示诸如超声波能量的信息的信息，例如从组织区域反射，形成表示所获得信息的相应输入矩阵，输入矩阵分别包括感兴趣集合和至少一个对应于 相邻于感兴趣集合的空间位置附近的空间位置，在各个输入矩阵上执行各自的奇异值分解，以获得对应于各组奇异矢量的各组奇异值，获得各自的输出矩阵，包括对相应投影加权 将相关的感兴趣整体集合到包含在相应的一组奇异矢量中的奇异矢量中的至少一个，并且使用相应的输出矩阵，确定至少一个 部分组织区域。

    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES
    5.
    发明申请
    SYSTEM AND METHOD FOR BINDING DYNAMICS OF TARGETED MICROBUBBLES 有权
    用于绑定微量元素动力学的系统和方法

    公开(公告)号：US20150150534A1

    公开(公告)日：2015-06-04

    申请号：US14559422

    申请日：2014-12-03

    申请人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    发明人： F. William Mauldin, JR. ,  Shiying Wang ,  John A. Hossack ,  Alexander L. Klibanov

    IPC分类号： A61B8/08 ,  A61B8/00

    CPC分类号： A61B8/481 ,  A61B8/0891 ,  A61B8/587 ,  G06T7/0016 ,  G06T2207/10132 ,  G06T2207/30104

    摘要： An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.

    摘要翻译： 一种超声系统和方法，其可以包括：接收波束形成器，被配置为从换能器接收信号; 耦合到所述接收波束形成器的处理器，所述处理器被配置为：分析从感兴趣区域反射的回波数据，所述回波数据由所发射的脉冲序列引起; 使用回波数据，确定在感兴趣区域内随时间的粘附微泡区域的信号幅度的集中趋势; 确定信号幅度的时间序列; 使用时间序列，确定初始信号幅度参数; 使用时间序列获得饱和信号参数和残差信号参数; 并确定指示残留信号幅度与饱和信号幅度相关的信息的相对指示。

    ULTRASOUND FOR LOCATING ANATOMY OR PROBE GUIDANCE
    6.
    发明申请
    ULTRASOUND FOR LOCATING ANATOMY OR PROBE GUIDANCE 有权
    用于定位解剖学或探针指导的超声波

    公开(公告)号：US20120296213A1

    公开(公告)日：2012-11-22

    申请号：US13574738

    申请日：2011-01-28

    申请人： F. William Mauldin, JR. ,  Francesco Viola ,  William F. Walker

    发明人： F. William Mauldin, JR. ,  Francesco Viola ,  William F. Walker

    IPC分类号： A61B8/12 ,  A61B8/14 ,  A61B8/00

    CPC分类号： A61B17/3403 ,  A61B8/0841 ,  A61B8/42 ,  A61B8/4254 ,  A61B8/4281 ,  A61B17/3401 ,  A61B46/10 ,  A61B2017/3413 ,  A61B2034/2048 ,  A61B2090/378

    摘要： A hand-held apparatus can be used to assist in guiding a probe or locating a particular anatomical target in a subject. The apparatus can include an ultrasonic transducer located on or within a housing and configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. In an example, the apparatus can include a motion tracking circuit configured to provide information indicative of a motion of the hand-held apparatus to the processor circuit, and a display configured to present information about a location of the target with respect to a portion of the hand-held apparatus, the information about the location determined by the processor circuit using the obtained information indicative of the ultrasonic energy reflected by the target and the information indicative of the motion of the hand-held apparatus.

    摘要翻译： 可以使用手持式装置来帮助引导探针或将特定解剖学靶定位在受试者中。 该装置可以包括位于壳体上或壳体内的超声波换能器，其被配置为产生被引导到对象的组织中的超声波能量，并被配置为接收由位于组织内的靶反射的超声能量的一部分。 在一个示例中，该装置可以包括运动跟踪电路，其被配置为向处理器电路提供指示手持设备的运动的信息;以及显示器，被配置为呈现关于目标的位置相对于 手持设备，使用所获得的指示由目标反射的超声能量的信息和由表示手持设备的运动的信息由处理器电路确定的位置的信息。