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公开(公告)号：US08703808B2
公开(公告)日：2014-04-22
申请号：US13588600
申请日：2012-08-17
申请人： Catherine Guillou , Frank Kozielski , Christophe Labriere , Francoise Gueritte , Sergey Tcherniuk , Dimitrios Skoufias , Claude Thal , Henri-Philippe Husson
发明人： Catherine Guillou , Frank Kozielski , Christophe Labriere , Francoise Gueritte , Sergey Tcherniuk , Dimitrios Skoufias , Claude Thal , Henri-Philippe Husson
IPC分类号： A01N43/38 , A61K31/405 , C07D209/04
CPC分类号： C07D209/18 , C07D209/20 , C07D263/52 , C07D401/06 , C07D403/06 , C07D405/06 , C07D407/06 , C07D409/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.
摘要翻译： 本发明涉及具有通式（I）的吲哚衍生物的用途如下：制备用于治疗癌症的药物组合物。
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公开(公告)号：US20130131084A1
公开(公告)日：2013-05-23
申请号：US13588600
申请日：2012-08-17
申请人： Catherine GUILLOU , Frank Kozielski , Christophe Labriere , Francoise Gueritte , Sergey Tcherniuk , Dimitrios Skoufias , Claude Thal , Henri-Philippe Husson
发明人： Catherine GUILLOU , Frank Kozielski , Christophe Labriere , Francoise Gueritte , Sergey Tcherniuk , Dimitrios Skoufias , Claude Thal , Henri-Philippe Husson
IPC分类号： C07D471/04 , C07D263/52 , C07D407/06 , C07D403/06 , C07D401/06 , C07D209/20
CPC分类号： C07D209/18 , C07D209/20 , C07D263/52 , C07D401/06 , C07D403/06 , C07D405/06 , C07D407/06 , C07D409/06 , C07D471/04 , C07D498/04
摘要： The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.
摘要翻译： 本发明涉及具有通式（I）的吲哚衍生物的用途如下：制备用于治疗癌症的药物组合物。
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公开(公告)号：US4033969A
公开(公告)日：1977-07-05
申请号：US617695
申请日：1975-09-29
IPC分类号： C07D461/00 , C07D471/22 , C07D459/00
CPC分类号： C07D461/00
摘要： New compounds having the formula ##STR1## in which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula : ##STR2## in which R is H or C.sub.2 H.sub.5.
摘要翻译： 具有式“IMAGE”的新化合物，其中Y表示氢原子，其中Z1和Z2同时表示氧原子，或Z1表示甲氧基羰基，Z2表示羟基，或Y和Z2一起形成碳 - 碳 键和Z1是甲氧基羰基，所述化合物的另外特征在于D / E环的顺式融合。 所述新化合物和长春胺及其某些衍生物由具有下式的烯胺制备：其中R为H或C 2 H 5。
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4.发明授权Vincamine derivatives and process for the preparation of vincamine and derivatives thereof 失效VINCAMINE衍生物及其制备方法及其衍生物
公开(公告)号：US3937709A
公开(公告)日：1976-02-10
申请号：US370334
申请日：1973-06-15
IPC分类号： C07D461/00 , C07D471/14 , C07D471/04
CPC分类号： C07D471/14 , C07D461/00
摘要： New compounds having the formula ##SPC1##In which Y represents a hydrogen atom, in which case Z.sub.1 and Z.sub.2 represent simultaneously an oxygen atom, or Z.sub.1 represents a methoxycarbonyl radical and Z.sub.2 a hydroxy radical, or Y and Z.sub.2 form together a carbon-carbon bond and Z.sub.1 is a methoxycarbonyl radical, said compounds being additionally characterized by a cis-fusion of the D/E rings. Said new compounds and vincamine and certain of its derivatives are prepared from an enamine having the formula: ##SPC2##In which R is H or C.sub.2 H.sub.5.
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公开(公告)号：USRE41366E1
公开(公告)日：2010-06-01
申请号：US12283904
申请日：2002-06-14
IPC分类号： C07D491/04 , C07D493/10 , C07D311/96 , C07D307/91 , C07D317/72
CPC分类号： C07D221/20 , C07D307/91 , C07D311/96 , C07D317/72 , C07D491/10 , C07D493/10 , Y02P20/55
摘要： The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom, R2=a hydroxy group, R1 and R2 together form ═O, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2)alkoxy group, R6═H, (C1-C12)alkyl, (CH2)nNR7R8, or —(CH2)nN+R7R8R9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.
摘要翻译： 本发明涉及合成加兰他敏的方法，式（1）的衍生物和类似物，其中R 1 =氢原子，R 2 =羟基，R 1和R 2一起独立地形成≡O，R 3，R 4和R 5 =氢原子，羟基或（C1-C2）烷氧基，R6 = H，（C1-C12）烷基，（CH2）nNR7R8或 - （CH2）nN + R7R8R9其中n = 1〜12，Z = 2个氢原子，或氧原子，X =氧，硫或氮原子，或-SO，-SO 2或-NR 6基团，其中R 6如上所定义或者是胺保护基团。
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公开(公告)号：US07109327B2
公开(公告)日：2006-09-19
申请号：US10480722
申请日：2002-06-14
IPC分类号： C07D491/04 , C07D493/10 , C07D311/96 , C07D307/91 , C07D317/72
CPC分类号： C07D221/20 , C07D307/91 , C07D311/96 , C07D317/72 , C07D491/10 , C07D493/10 , Y02P20/55
摘要： The invention relates to a method for the synthesis of galanthamifle, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form ═O, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1–C2)alkoxy group, R6═H, (C1–C12)alkyl, (CH2)nNR7R8, or —(CH2)nN′R7R8R9 where n=1 to 12, Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group
摘要翻译： 本发明涉及合成其中R 1 =氢原子的式（1）的衍生物和类似物的加兰他滨的方法。 R 2 =羟基，R 1和R 2一起形成-O，R 3，R 3， R 4和R 5独立地为氢原子，羟基或（C 1 -C 2 -C 2）烷基， 烷氧基，R 6 -H，（C 1 -C 12 - ）烷基，（CH 2 2） 或者 - （CH 2）n N R R 8，或 - （CH 2）n N 其中n = 1至12，Z =两个氢原子或氧原子，X =氧，硫 或氮原子，或-SO 3 -SO 2 - 或-NR 6 C 6基团，其中R 6如上所定义，或者是胺 保护组
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公开(公告)号：US20050065338A1
公开(公告)日：2005-03-24
申请号：US10480722
申请日：2002-06-14
IPC分类号： C07D221/20 , C07D307/91 , C07D311/96 , C07D317/72 , C07D491/10 , C07D493/10 , C07D205/00
CPC分类号： C07D221/20 , C07D307/91 , C07D311/96 , C07D317/72 , C07D491/10 , C07D493/10 , Y02P20/55
摘要： The invention relates to a method for the synthesis of galanthamine, the derivatives and analogues thereof of formula (1) where R1=a hydrogen atom. R2=a hydroxy group, R1 and R2 together form =0, R3, R4, and R5 independently=a hydrogen atom, a hydroxy group or a (C1-C2) alkoxy group, R6-11 , (C1-C12) alkyl, (CH2)nNR7R8, or —(CH2)nN′R7R8R9 where n−1 to 12 Z=two hydrogen atoms, or an oxygen atom and X=an oxygen, sulphur or nitrogen atom, or a —SO, —SO2, or —NR6 group where R6 is as defined above or is an amine protecting group.
摘要翻译： 本发明涉及合成加兰他敏的方法，其中R 1 =氢原子的式（1）的衍生物和类似物。 R2 =羟基，R1和R2一起形成= 0，R3，R4和R5独立地为氢原子，羟基或（C1-C2）烷氧基，R6-11，（C1-C12）烷基， （CH2）nNR7R8或 - （CH2）nN'R7R8R9其中n-1至12Z = 2个氢原子，或氧原子，X =氧，硫或氮原子，或-SO，-SO2或 - NR 6基团，其中R 6如上所定义或是胺保护基团。
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公开(公告)号：US5958903A
公开(公告)日：1999-09-28
申请号：US983309
申请日：1998-01-09
申请人： Dolor Renko , Pierre Potier , Yves Christen , Claude Thal , Catherine Guillou , Aude Mary
发明人： Dolor Renko , Pierre Potier , Yves Christen , Claude Thal , Catherine Guillou , Aude Mary
IPC分类号： C07D491/06 , A61K31/00 , A61K31/55 , A61P25/28 , A61P43/00 , C07D491/10 , C07D491/08 , A01N57/00
CPC分类号： C07D491/10
摘要： Novel galanthamine derivatives of general fonnulae (Ia) and (Ib), a method for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as cholinesterase inhibitors, are disclosed. ##STR1##
摘要翻译： PCT No.PCT / FR96 / 01139 Sec。 371日期1998年1月9日 102（e）1998年1月9日PCT PCT 1996年7月19日PCT公布。 公开号WO97 / 03987 日期1997年2月6日公开了通用型（Ia）和（Ib）的新颖的雪花胺衍生物，其制备方法，含有所述衍生物的药物组合物及其用途，特别是胆碱酯酶抑制剂。
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公开(公告)号：US5602131A
公开(公告)日：1997-02-11
申请号：US354660
申请日：1994-12-13
申请人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
发明人： Jean-Daniel Brion , Claude Thal , Luc Demuynck , Jean-Gilles Parmentier , Jean Lepagnol , Pierre Lestage , Jean-Fran.cedilla.ois Pujol , Pascal Schmitt , Pierre Potier
IPC分类号： C07D471/06 , A61K31/435 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07D461/00 , C07D471/22 , C07D471/04 , A61K31/44 , A61K31/50 , C07D471/14
CPC分类号： C07D461/00
摘要： A compound selected from those of general formula (I): ##STR1## wherein A represents a bivalent radical selected from ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and Z are as defined in the description,the isomers and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of depression and anxiety.
摘要翻译： 选自通式（I）的化合物：其中A表示选自以下的二价基团：R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和Z分别为 如本说明书中所定义，其异构体和药学上可接受的酸或碱加成盐，以及含有它们的药物，可用于治疗抑郁和焦虑。
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10.发明授权Use of biguanide derivatives for making a medicine having a wound healing effect 有权使用双胍衍生物制造具有伤口愈合作用的药物公开(公告)号：US07199159B2
公开(公告)日：2007-04-03
申请号：US10297003
申请日：2001-05-23
申请人： Pierre Jean-Paul Potier , Nobumichi-André Sasaki , Maria Conception Achab , Gisèle Franck , Claude Thal , Joanna Bakala
发明人： Pierre Jean-Paul Potier , Nobumichi-André Sasaki , Maria Conception Achab , Gisèle Franck , Claude Thal , Joanna Bakala
IPC分类号： A61K31/155
CPC分类号： A61K31/155 , Y10S514/969
摘要： The present invention relates to the use of biguanide derivatives of general formula I below: in which: the groups R1 and R2 represent, independently of each other, a hydrogen atom, a C1–C7, alkyl group, a cycloalkyl group, a heterocycle, a C2–C7 alkenyl group, an aryl group, an aralkyl group, an aryloxyalkyl group or a heteroaryl group, or R1 and R2, taken together, represent a C2–C7 alkylene which may contain one or more hetero atoms, and the group R3 represents a primary, secondary or tertiary amine, or pharmaceutically acceptable salts thereof, to manufacture a medicinal product with cicatrizing action, the said medicinal product being in a pharmaceutical form for topical use.
摘要翻译： 本发明涉及以下通式I的双胍衍生物的用途：
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