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1.发明授权公开(公告)号：US08900829B2
公开(公告)日：2014-12-02
申请号：US13096932
申请日：2011-04-28
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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2.发明申请公开(公告)号：US20110244458A1
公开(公告)日：2011-10-06
申请号：US13096932
申请日：2011-04-28
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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3.发明授权公开(公告)号：US07951563B2
公开(公告)日：2011-05-31
申请号：US11911617
申请日：2006-04-17
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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4.发明申请公开(公告)号：US20100184027A1
公开(公告)日：2010-07-22
申请号：US12373709
申请日：2007-07-13
申请人： Catherine Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Catherine Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和区分增殖性疾病之间或之中的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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5.发明申请公开(公告)号：US20090075260A1
公开(公告)日：2009-03-19
申请号：US11911617
申请日：2006-04-17
申请人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
发明人： Juergen Distler , Thomas Hildmann , Ralf Lesche , Catherine Lofton-Day , Fabian Model , Matthias Schuster , Andrew Z. Sledziewski , Reimo Tetzner , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明的方面提供用于检测或检测和区分肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之中的方法，核酸和试剂盒。 具体方面公开并提供基因组序列，其甲基化模式具有用于改善所述疾病类别的检测和分化的实质性用途，从而能够改善患者的诊断和治疗。
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公开(公告)号：US09695478B2
公开(公告)日：2017-07-04
申请号：US12779856
申请日：2010-05-13
申请人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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7.发明授权公开(公告)号：US07749702B2
公开(公告)日：2010-07-06
申请号：US11405322
申请日：2006-04-17
申请人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Catherine E. Lofton-Day , Andrew Z. Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和鉴别肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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8.发明申请公开(公告)号：US20060286576A1
公开(公告)日：2006-12-21
申请号：US11405322
申请日：2006-04-17
申请人： Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
发明人： Cathy Lofton-Day , Andrew Sledziewski , Ralf Lesche , Matthias Schuster , Juergen Distler , Reimo Tetzner , Thomas Hildmann , Fabian Model , Xiaoling Song
CPC分类号： C12Q1/6886 , C12Q1/6806 , C12Q2600/106 , C12Q2600/112 , C12Q2600/154 , C12Q2600/158
摘要： The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
摘要翻译： 本发明提供用于检测或检测和鉴别肝细胞增殖性疾病或用于检测或检测和鉴别结直肠细胞增殖性疾病之间或之间的方法，核酸和试剂盒。 本发明公开了基因组序列，其甲基化模式可用于改善所述疾病类别的检测和分化，从而能够改善患者的诊断和治疗。
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9.发明申请公开(公告)号：US20090197250A1
公开(公告)日：2009-08-06
申请号：US11720744
申请日：2005-12-02
申请人： Susan Cottrell , Fabian Model , Carolina Haefliger , Gunter Weiss , Juergen Distler , Andrew Z. Sledziewski , Xiaoling Song , Thomas L. Skillman , Jeffrey G. Thomas
发明人： Susan Cottrell , Fabian Model , Carolina Haefliger , Gunter Weiss , Juergen Distler , Andrew Z. Sledziewski , Xiaoling Song , Thomas L. Skillman , Jeffrey G. Thomas
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/154 , C12Q2600/158 , C12Q2600/16 , G01N33/57434 , G01N2800/60
摘要： Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
摘要翻译： 具体方面提供具有用于提供前列腺细胞增殖性疾病的预后的实质性用途的新型方法和组合物（例如，核酸，试剂盒等）。 在特定方面，这通过分析一组基因或其子集的表达状态来实现。
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公开(公告)号：US20050246799A1
公开(公告)日：2005-11-03
申请号：US10972587
申请日：2004-10-25
申请人： Xiaoling Song , Pauline Bariola , Nora Linderoth , Hao Fan , Zhong-Min Wei
发明人： Xiaoling Song , Pauline Bariola , Nora Linderoth , Hao Fan , Zhong-Min Wei
CPC分类号： C12N15/8281 , C07K14/415 , C12N15/8261 , C12N15/8279 , C12N15/8283 , Y02A40/146
摘要： The present invention is directed to an isolated protein which serves as a receptor in plants for a plant pathogen hypersensitive response elicitor. Also disclosed are nucleic acid molecules encoding such receptors as well as expression vectors, host cells, transgenic plants, and transgenic plant seeds containing such nucleic acid molecules. Both the protein and nucleic acid can be used to identify agents targeting plant cells to enhance a plant's receptivity to treatment with a hypersensitive response elicitor and to directly impart plant growth enhancement as well as resistance against disease, insects, and stress.
摘要翻译： 本发明涉及用作植物病原体过敏反应诱发剂的植物中的受体的分离蛋白质。 还公开了编码这种受体以及表达载体，宿主细胞，转基因植物和含有这种核酸分子的转基因植物种子的核酸分子。 蛋白质和核酸都可用于鉴定靶向植物细胞的药剂，以增强植物对过敏反应诱发剂治疗的接受性，并直接赋予植物生长增强以及抵抗疾病，昆虫和压力。
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