公开(公告)号：US08592592B2

公开(公告)日：2013-11-26

申请号：US13076632

申请日：2011-03-31

申请人： Catherine Tachdjian ,  Xiao Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy Davis ,  Vincent Darmohusodo ,  Melissa Wong ,  Victor Selchau

发明人： Catherine Tachdjian ,  Xiao Qing Tang ,  Donald S. Karanewsky ,  Guy Servant ,  Xiaodong Li ,  Feng Zhang ,  Qing Chen ,  Hong Zhang ,  Timothy Davis ,  Vincent Darmohusodo ,  Melissa Wong ,  Victor Selchau

IPC分类号： C07D215/42

CPC分类号： C07D495/04 ,  A23L2/56 ,  A23L27/2054 ,  A23L27/88 ,  A23V2002/00 ,  A61K47/22 ,  C07D215/54 ,  C07D215/60 ,  C07D401/12 ,  C07D405/12 ,  C07D471/04 ,  C07D491/048

摘要： The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

公开(公告)号：US20070173488A1

公开(公告)日：2007-07-26

申请号：US11560460

申请日：2006-11-16

申请人： Pierre-Yves Bounaud ,  Stephanie Hopkins ,  Elizabeth Jefferson ,  Mark Wilson ,  Melissa Wong ,  Toufike Kanouni

发明人： Pierre-Yves Bounaud ,  Stephanie Hopkins ,  Elizabeth Jefferson ,  Mark Wilson ,  Melissa Wong ,  Toufike Kanouni

IPC分类号： A61K31/55 ,  A61K31/454 ,  A61K31/43 ,  C07D487/02

CPC分类号： C07D513/04

摘要： The present invention provides pyrazolothiazole kinase modulators, methods of treating certain disease states, such as cancer, and pharmaceutical composition thereof.

摘要翻译： 本发明提供吡唑并噻唑激酶调节剂，治疗某些疾病状态如癌症的方法及其药物组合物。

公开(公告)号：US20070185061A1

公开(公告)日：2007-08-09

申请号：US11556944

申请日：2006-11-06

申请人： David Campbell ,  David Winn ,  Juan Betancort ,  Kevin Shreder ,  Yi Hu ,  Bei Li ,  Melissa Wong ,  Lifu Ma ,  William Ripka ,  Min Wu

发明人： David Campbell ,  David Winn ,  Juan Betancort ,  Kevin Shreder ,  Yi Hu ,  Bei Li ,  Melissa Wong ,  Lifu Ma ,  William Ripka ,  Min Wu

IPC分类号： A61K31/69 ,  C07F5/02

CPC分类号： C07F5/025

摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CRiRii, R1, R2, R3, R4 and R5 are as described herein.

摘要翻译： 提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X是CH 2 2; S; O; CF 2或C（CH 3）2）2。 Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C 3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R 7独立或独立地取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; 和R 1，R 2，R 2，R 3，R 3， R 4和R 5如本文所述。