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公开(公告)号：US06235061B1
公开(公告)日：2001-05-22
申请号：US08222662
申请日：1994-04-04
申请人： Cato T. Laurencin , Saadiq El-Amin , Archel M. A. Ambrosio , Shawn R. Pucher , Harry R. Allcock
发明人： Cato T. Laurencin , Saadiq El-Amin , Archel M. A. Ambrosio , Shawn R. Pucher , Harry R. Allcock
IPC分类号： A61F228
CPC分类号： C08G79/025 , A61F2/28 , A61F2002/30062 , A61F2210/0004 , A61L27/18 , A61L2430/02 , A61L27/58 , C08L85/02
摘要： A highly porous three-dimensional biodegradable poly(organophosphazene) matrix with hydrolytically unstable side chains is prepared and used as a scaffold for the growth of osteoblast cells. In a preferred embodiment, the poly(organophosphazene) includes between 10 and 90% hydrolytically unstable side chains including glucosyl, glyceryl, glyceryl, imidazolyl or ethoxy units, for example, poly[(methylphenoxy)(ethyl glycinato) phosphazene]. The addition of the glucosyl, glycinyl or glyceryl side chains to the polymer can also be used generally to enhance growth rates of cells adhered to the polymer, presumably through uptake and metabolism of the simple sugar or alcohol units.
摘要翻译： 制备具有水解不稳定侧链的高度多孔的三维可生物降解的聚（有机膦腈）基质，并用作成骨细胞生长的支架。 在优选的实施方案中，聚（有机膦腈）包括10-90％水解不稳定的侧链，包括葡糖基，甘油基，甘油基，咪唑基或乙氧基单元，例如聚[（甲基苯氧基）（乙基甘氨酸）磷腈]。 甘油基，甘氨酰或甘油侧链加入到聚合物中通常也可用于增强附着于聚合物上的细胞的生长速度，这可能是通过单糖或醇单元的摄取和代谢。
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公开(公告)号：US5898062A
公开(公告)日：1999-04-27
申请号：US833868
申请日：1997-04-10
IPC分类号： C08G79/02
CPC分类号： C08G79/025
摘要： Poly (organophosphazene) polymers bearing various ratios of a carboxylic acid containing sidegroup and an alkylamino, alkoxy, or alkoxy ether sidegroup are disclosed. These water-soluble macromolecules are cross-linked and allowed to absorb water to form hydrogels. Because of their anionic character and high water content, the polymeric hydrogels are useful for a wide variety of biomedical applications including controlled drug delivery (e.g. pH sensitive drug delivery), biocompatible coatings, and pH sensitive membranes.
摘要翻译： 公开了含有羧酸侧基和烷基氨基，烷氧基或烷氧基醚侧基的各种比例的聚（有机膦腈）聚合物。 这些水溶性大分子被交联并允许吸收水以形成水凝胶。 由于其阴离子特性和高水含量，聚合物水凝胶可用于各种生物医学应用，包括受控药物递送（例如pH敏感药物递送），生物相容性涂层和pH敏感膜。
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公开(公告)号：US07235295B2
公开(公告)日：2007-06-26
申请号：US10938493
申请日：2004-09-10
申请人： Cato T. Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry R. Allcock , Jared D. Bender , Paul W. Brown , Yaser E. Greish
发明人： Cato T. Laurencin , Lakshmi Sreedharan Nair , Subhabrata Bhattacharyya , Harry R. Allcock , Jared D. Bender , Paul W. Brown , Yaser E. Greish
CPC分类号： A61L27/50 , A61L27/18 , A61L31/10 , Y10T428/1369 , Y10T428/249924 , Y10T428/2913 , C08L85/02
摘要： Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.
摘要翻译： 已经开发了可用于各种医疗和其他应用的聚合物纳米纤维，例如过滤装置，医疗假体，用于组织工程的支架，伤口敷料，受控药物递送系统，化妆品皮肤面罩和防护服。 这些可以由不可降解或可降解的各种不同聚合物中的任何一种形成。 在以下实施例中证明的优选实施方案中，纳米纤维由可生物降解和不可生物降解的聚磷腈，它们与其它聚磷腈或与有机，无机/有机金属聚合物的共混物以及具有纳米尺寸颗粒如羟基磷灰石的聚磷腈的复合纳米纤维形成。
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公开(公告)号：US06759157B1
公开(公告)日：2004-07-06
申请号：US09590985
申请日：2000-06-09
IPC分类号： H01M810
CPC分类号： B01D67/0011 , B01D2325/20 , B01D2325/26 , C08J5/22 , H01M8/04197 , H01M8/1034 , H01M8/1067 , Y02P70/56
摘要： Proton conducting membranes having improved resistance to methanol crossover are provided, along with methods for their manufacture. In a preferred embodiment, the polymeric membranes are formed by (a) dissolving a polymer, preferably a polyphosphazene, in an organic solvent to form a polymer solution; (b) adding an oxyacid to the polymer solution; (c) optionally, adding water to the polymer solution, preferably in a molar ratio equivalent to the oxyacid; (d) optionally, concentrating the polymer solution; (e) casting the polymer solution on a casting surface, such as one formed of or coated with TEFLON™; and (f) removing the organic solvent, so as to form the polymeric membrane. A particularly useful application for these polymeric membranes is in fuel cells, such as those wherein methanol and oxygen are converted into electrical energy.
摘要翻译： 提供了具有改进的抗甲醇交联性的质子导电膜及其制造方法。 在优选的实施方案中，聚合物膜通过（a）将聚合物，优选聚磷腈溶解在有机溶剂中形成聚合物溶液而形成; （b）向聚合物溶液中加入含氧酸; （c）任选地，向聚合物溶液中加入水，优选以相对于含氧酸的摩尔比加入; （d）任选地，浓缩聚合物溶液; （e）将聚合物溶液浇铸在诸如由TEFLON TM形成或涂覆的铸造表面上; 和（f）除去有机溶剂，以便形成聚合物膜。 这些聚合物膜的特别有用的应用是在燃料电池中，例如其中甲醇和氧被转化为电能的那些。
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公开(公告)号：US06482910B1
公开(公告)日：2002-11-19
申请号：US09644592
申请日：2000-08-23
申请人： Harry R. Allcock , Walter R. Laredo
发明人： Harry R. Allcock , Walter R. Laredo
IPC分类号： C08F23620
CPC分类号： C08G61/02 , C08F132/08 , C08G61/06 , C08G61/08
摘要： A polymer composition comprising a polynorbonene backbone and pendant cyclotriphosphazene groups has been developed. The pendant cyclotriphosphazene group can have various substituents such as C1-C10 alkyl, C1-C10 haloalkyl, C3-C6 cycloalkyl, phenyl, substituted phenyl, aryl, —(CH2CH2OCH2CH2)nOCH3 in which n is a positive integer, aminoalkyl, alkoxyalkyl, phenoxyalkyl, aryloxyalkyl and amidoalkyl. The polynorbonene backbone can have substituents such as H, CH3, X which is a halo group, and C2-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkoxy, phenoxy, and aryloxy. In a preferred embodiment, the pendant triphosphazene group can have either —CH2CF3, phenyl, 4-ethylcarboxylatophenyl, —CH2CH3, or —CH2CH2OCH2CH2OCH3 while the polynorbonene backbone can have H and low alkyl groups. The polyphosphazene compositions can be prepared readily via ring-opening-metathesis-polymerization of an olefin having norbornene structure with pendant cyclotriphosphazene groups. The polyphosphazene compositions disclosed are useful as elastomers, optical materials, electrically conductive materials, biomedical materials, compatibilizing agents, surfactants, additives for coatings, and as flame retardants.
摘要翻译： 已经开发了包含聚碳链烷骨架和侧链三磷腈基团的聚合物组合物。 侧环三膦腈基可以具有各种取代基，例如C1-C10烷基，C1-C10卤代烷基，C3-C6环烷基，苯基，取代的苯基，芳基， - （CH2CH2OCH2CH2）nOCH3，其中n是正整数，氨基烷基，烷氧基烷基，苯氧基烷基 ，芳氧基烷基和酰氨基烷基。 多亚碳烯骨架可以具有取代基，例如H，CH 3，X是卤素基团，和C 2 -C 6烷基，C 3 -C 6环烷基，C 2 -C 6烷氧基，苯氧基和芳氧基。 在一个优选的实施方案中，三膦酰基侧基可以具有-CH 2 CF 3，苯基，4-乙基羧基苯基，-CH 2 CH 3或-CH 2 CH 2 OCH 2 CH 2 OCH 3，而多亚氮烷骨架可具有H和低级烷基。 聚磷腈组合物可以通过具有降冰片烯结构的烯烃与侧链三环磷腈基团的开环 - 复分解聚合来容易地制备。 所公开的聚磷腈组合物可用作弹性体，光学材料，导电材料，生物医学材料，相容剂，表面活性剂，涂料用添加剂和阻燃剂。
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6.发明授权Blends of polyurethane and polyphosphazene and their use as flame-retardant foamed compositions 失效聚氨酯和聚磷腈的共混物及其作为阻燃发泡组合物的用途
公开(公告)号：US5965627A
公开(公告)日：1999-10-12
申请号：US852769
申请日：1997-05-07
CPC分类号： C08G18/6461 , C08L85/02 , C08G2101/00
摘要： Flame-retardant polymer blends of a polyurethane polymer or prepolymer and a poly(organophosphazene) are disclosed. Preferred poly(organophosphazenes) contain functional groups capable of reacting with isocyanate groups present during the curing of the polyurethane. The blends are preferably formulated by reacting the poly(organophosphazene) containing functional groups under conditions where some of the functional groups of the poly(organophosphazene) can react with the isocyanate groups present during the polymerization and curing of the polyurethane. These polymer blends are useful for making flame-retardant foamed articles of manufacture.
摘要翻译： 公开了聚氨酯聚合物或预聚物和聚（有机膦腈）的阻燃聚合物共混物。 优选的聚（有机膦腈）含有能够在聚氨酯固化期间与异氰酸酯基反应的官能团。 混合物优选通过在聚（有机膦腈）的一些官能团可以与在聚氨酯的聚合和固化期间存在的异氰酸酯基团反应的条件下使含有聚（有机膦腈）的官能团的反应来配制。 这些聚合物共混物可用于制造阻燃发泡制品。
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7.发明授权Polyphosphazenes with unsaturated side groups useful as reaction intermediates, cross-linkable polymers, and as components of interpenetrating polymer networks 失效具有不饱和侧基的聚磷腈可用作反应中间体，可交联聚合物，以及互穿聚合物网络的组分
公开(公告)号：US5747604A
公开(公告)日：1998-05-05
申请号：US589747
申请日：1996-04-01
申请人： Harry R. Allcock , Karyn Visscher , Young Baek Kim
发明人： Harry R. Allcock , Karyn Visscher , Young Baek Kim
IPC分类号： C08G79/02 , C08L85/02 , C08L101/00
CPC分类号： C08G79/025 , C08L85/02 , C08L101/00 , Y10S525/903
摘要： A number of new poly(organophosphazenes) have been synthesized which bear 2-butenoxy or 4-allyloxyphenylphenoxy side groups. Co-substituent groups included trifluoroethoxy, phenoxy, or benzyloxyphenoxy groups. Species with 4-allyloxyphenylphenoxy units underwent Si--H coupling to linear silanes or siloxanes to extend the side groups and form hybrid phosphazene/organosilicon polymers. A number of these polymers are rubbery elastomers which are readily cross-linked by heat or light. Seven of the mixed-substituent, cross-linked polymers were incorporated into interpenetrating polymer networks (IPN's) with polystyrene, poly(methyl methacrylate), polyacrylonitrile, poly(acrylic acid) and poly(dimethylsiloxane). The phase compatibility characteristics of the IPN's were assessed by DSC, TEM, FT-IR spectroscopy, and 1H and 31P NMR spectroscopy data.
摘要翻译： 已经合成了许多具有2-丁烯氧基或4-烯丙氧基苯基苯氧基侧基的新的聚（有机膦腈）。 共取代基包括三氟乙氧基，苯氧基或苄氧基苯氧基。 具有4-烯丙氧基苯基苯氧基单元的物质经历与线性硅烷或硅氧烷的Si-H偶联以延伸侧基并形成杂化磷腈/有机硅聚合物。 许多这些聚合物是通过热或轻易交联的橡胶状弹性体。 混合取代的交联聚合物中的7个与聚苯乙烯，聚（甲基丙烯酸甲酯），聚丙烯腈，聚（丙烯酸）和聚（二甲基硅氧烷）掺入互穿聚合物网络（IPN）中。 通过DSC，TEM，FT-IR光谱和1H和31P NMR光谱数据评估IPN的相位相容性。
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公开(公告)号：US5562909A
公开(公告)日：1996-10-08
申请号：US090841
申请日：1993-07-12
IPC分类号： A61K39/385 , A61K9/16 , A61K39/39 , C08G79/02
CPC分类号： C08G79/025 , A61K39/39 , A61K9/1641 , A61K2039/541 , A61K2039/55555
摘要： A immunoadjuvant soluble phosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are susceptible to hydrolysis under the conditions of use, to impart biodegradability to the polymer.
摘要翻译： 公开了一种免疫佐剂可溶性磷腈聚电解质。 在一个实施方案中，聚合物助剂是具有（i）含有例如羧酸，磺酸或羟基部分的离子化或可离子化侧基的聚（有机膦腈），和（ii）易于水解的侧基 使用条件，赋予聚合物生物降解性。
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公开(公告)号：US5457160A
公开(公告)日：1995-10-10
申请号：US157951
申请日：1993-11-24
摘要： Polymer blends of the following:(i) poly[bis(methylamino)phosphazene] and poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene;(ii) poly[bis(methylamino)phosphazene] with poly(vinyl chloride), poly(methyl methacrylate), poly(ethylene oxide), or polystyrene;(iii) poly[bis(2-(2-methoxyethoxy)ethoxy)phosphazene with poly(vinyl alcohol) or poly(acrylic acid); and(iv) poly[bis(phenoxy)phosphazene] with polystyrene or poly(methyl methacrylate).
摘要翻译： 以下聚合物共混物：（i）聚[双（甲基氨基）磷腈]和聚[双（2-（2-（2-甲氧基乙氧基）乙氧基）磷腈） （ii）与聚（氯乙烯），聚（甲基丙烯酸甲酯），聚（环氧乙烷）或聚苯乙烯的聚[双（甲基氨基）磷腈] （iii）聚[二（2-（2-甲氧基乙氧基）乙氧基）磷腈与聚（乙烯醇）或聚（丙烯酸）; 和（iv）聚[双（苯氧基）磷腈]与聚苯乙烯或聚（甲基丙烯酸甲酯）。
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公开(公告)号：US4636387A
公开(公告)日：1987-01-13
申请号：US708907
申请日：1984-09-21
CPC分类号： A61K47/48223 , A61K31/80 , C08G79/025
摘要： A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and certain radicals having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitrogen single bond is disclosed along with medicaments containing such anesthetics. The radicals employed are 2-amino-4-picoline, benoxinate, naepaine and phenacaine.
摘要翻译： 一种长效局部麻醉剂，其包含聚合磷腈骨架，以及某些具有局部麻醉活性的基团和所述基团的环上的氨基官能团，所述基团通过磷 - 氮单键共价连接到磷腈骨架上 与包含这种麻醉剂的药物一起被公开。 所用的基团是2-氨基-4-甲基吡啶，苯草胺，奈帕因和吩非那韦。
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