公开(公告)号：US11845986B2

公开(公告)日：2023-12-19

申请号：US16374626

申请日：2019-04-03

Applicant: Cellular Research, Inc.

Inventor： Eleen Shum ,  Glenn Fu ,  Craig Betts

IPC: C12N15/10 ,  C12Q1/6874 ,  C12Q1/6806 ,  G16B25/00 ,  G16B25/10

CPC classification number: C12Q1/6874 ,  C12N15/1065 ,  C12N15/1093 ,  C12Q1/6806 ,  G16B25/00 ,  G16B25/10 ,  C12N15/1093 ,  C12Q2537/159 ,  C12N15/1093 ,  C12Q2537/159 ,  C12Q2563/179

Abstract: This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.

公开(公告)号：US20200157600A1

公开(公告)日：2020-05-21

申请号：US16194819

申请日：2018-11-19

Applicant: Cellular Research, Inc.

Inventor： Glenn Fu ,  Craig Betts ,  Christina Fan ,  Gretchen Yinbon Lam

IPC: C12Q1/6806 ,  C12Q1/6837 ,  C12Q1/6855 ,  C12N9/00 ,  C12N9/50 ,  C12N15/10

Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.

公开(公告)号：US10301677B2

公开(公告)日：2019-05-28

申请号：US15603239

申请日：2017-05-23

Applicant: Cellular Research, Inc.

Inventor： Eleen Shum ,  Glenn Fu ,  Craig Betts

IPC: C12Q1/68 ,  C12Q1/6874 ,  C12Q1/6806 ,  G06F19/20 ,  C12N15/10

Abstract: This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.

公开(公告)号：US20170342484A1

公开(公告)日：2017-11-30

申请号：US15603239

申请日：2017-05-23

Applicant: Cellular Research, Inc.

Inventor： Eleen Shum ,  Glenn Fu ,  Craig Betts

IPC: C12Q1/68 ,  C12N15/10 ,  G06F19/20

CPC classification number: C12Q1/6874 ,  C12N15/1065 ,  C12N15/1093 ,  C12Q1/6806 ,  G06F19/20 ,  C12Q2537/159 ,  C12Q2563/179

Abstract: This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.

公开(公告)号：US11332776B2

公开(公告)日：2022-05-17

申请号：US16781814

申请日：2020-02-04

Applicant: Cellular Research, Inc.

Inventor： Craig Betts ,  Glenn Fu

IPC: C12P19/34 ,  C12Q1/6806 ,  C12N15/10

Abstract: The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.

公开(公告)号：US20200216877A1

公开(公告)日：2020-07-09

申请号：US16781814

申请日：2020-02-04

Applicant: Cellular Research, Inc.

Inventor： Craig Betts ,  Glenn Fu

IPC: C12Q1/6806 ,  C12N15/10

Abstract: The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.

公开(公告)号：US20160312276A1

公开(公告)日：2016-10-27

申请号：US15134967

申请日：2016-04-21

Applicant: Cellular Research, Inc.

Inventor： Glenn Fu ,  Craig Betts ,  Christina Fan ,  Gretchen Yinbon Lam

IPC: C12Q1/68

CPC classification number: C12Q1/6855 ,  C12Q1/6806 ,  C12Q1/6837 ,  C12Q2521/327 ,  C12Q2521/507 ,  C12Q2525/155 ,  C12Q2563/179 ,  C12Q2525/191

Abstract: The disclosure provides for methods, compositions, systems, devices, and kits for whole transcriptome amplification using stochastic barcodes.

Abstract translation: 本公开提供了使用随机条形码的全转录组扩增的方法，组合物，系统，装置和试剂盒。

公开(公告)号：US20190292592A1

公开(公告)日：2019-09-26

申请号：US16374626

申请日：2019-04-03

Applicant: Cellular Research, Inc.

Inventor： Eleen Shum ,  Glenn Fu ,  Craig Betts

IPC: C12Q1/6874 ,  G16B25/00 ,  C12N15/10 ,  C12Q1/6806

Abstract: This disclosure provides methods and compositions for removing one or more high abundance species from a plurality of nucleic acid molecules. In some embodiments, the methods and compositions can be used for normalizing nucleic acid libraries. In some embodiments, molecular labels are used in conjunction with the methods and compositions disclosed herein to improve sequencing efficiency.

公开(公告)号：US20170073730A1

公开(公告)日：2017-03-16

申请号：US15260106

申请日：2016-09-08

Applicant: Cellular Research, Inc.

Inventor： Craig Betts ,  Glenn Fu

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12N15/1093 ,  C12N15/1096 ,  C12Q2525/191 ,  C12Q2537/159 ,  C12Q2523/305 ,  C12Q2525/155 ,  C12Q2525/186 ,  C12Q2531/113 ,  C12Q2537/143 ,  C12Q2563/131 ,  C12Q2563/143 ,  C12Q2563/149 ,  C12Q2535/122

Abstract: The disclosure provides for methods, compositions, and kits for normalizing nucleic acid libraries, for example sequencing libraries.

Abstract translation: 本公开提供了用于标准化核酸文库的方法，组合物和试剂盒，例如测序文库。