公开(公告)号：US09309275B2

公开(公告)日：2016-04-12

申请号：US14195388

申请日：2014-03-03

申请人： Idenix Pharmaceuticals, Inc. ,  Centre National De La Recherche Scientifique ,  Universite Montpellier 2 Sciences Et Techniques

发明人： Alistair James Stewart ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  Francois-Rene Alexandre ,  Dominique Surleraux ,  Christophe Claude Parsy ,  Claire Pierra ,  David Dukhan ,  Gilles Gosselin

IPC分类号： C07H19/044 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  A61K31/708 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/7072 ,  A61K45/06 ,  A61K31/40 ,  A61K31/497 ,  A61K31/7056 ,  A61K38/21

CPC分类号： C07H19/207 ,  A61K31/40 ,  A61K31/497 ,  A61K31/7056 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K38/212 ,  A61K45/06 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  A61K2300/00

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-deoxy nucleoside compounds according to Formula 3001a or 3001b: or a pharmaceutically acceptable salts, solvates, stereoisomeric forms, tautomeric forms, or polymorphic forms thereof, wherein PD, Base1 and Base2 are as provided herein.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式3001a或3001b的3'-脱氧核苷化合物：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中PD，碱基和碱基2如本文所提供。

公开(公告)号：US20160113956A1

公开(公告)日：2016-04-28

申请号：US14866759

申请日：2015-09-25

申请人： Centre National De La Recherche Scientifique ,  Universite Montpellier 2 Sciences Et Techniques ,  Idenix Pharmaceuticals, Inc.

发明人： David DUKHAN ,  Christophe Claude PARSY ,  Gilles GOSSELIN ,  Jean-François GRIFFON ,  Guillaume BRANDT ,  Cyril B. DOUSSON ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  Alistair James Stewart

IPC分类号： A61K31/7072 ,  A61K9/00 ,  A61K45/06 ,  C07H19/20 ,  A61K31/7076 ,  C07H19/10 ,  A61K31/7068

CPC分类号： A61K31/7072 ,  A61K9/0053 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  C07H17/02 ,  C07H19/073 ,  C07H19/10 ,  C07H19/173 ,  C07H19/20

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1 and R2 are as described herein.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式1001或2001的2'-氰基，叠氮基或氨基核苷：或其药学上可接受的盐，溶剂合物，立体异构形式，互变异构形式或其多晶型，其中基团，W，R 1和R 2 如本文所述。

公开(公告)号：US20160083413A1

公开(公告)日：2016-03-24

申请号：US14920830

申请日：2015-10-22

申请人： Idenix Pharmaceuticals, Inc. ,  Centre National De La Recherche Scientifique ,  Universite Montpellier 2 Sciences Et Techniques

发明人： Gilles Gosselin ,  Christophe Claude Parsy ,  François-René Alexandre ,  Houcine Rahali ,  Jean-François Griffon ,  Dominique Surleraux ,  Cyril B. Dousson ,  Claire Pierra ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  Alistair James Stewart ,  David Dukhan

IPC分类号： C07H19/10 ,  A61K45/06 ,  A61K31/7072

CPC分类号： C07H19/10 ,  A61K31/403 ,  A61K31/497 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7105 ,  A61K38/212 ,  A61K45/06 ,  C07H19/06 ,  C07H19/11 ,  C07H19/12 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H19/213 ,  C07H19/23 ,  A61K2300/00

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物是根据式2001的2'-氯核苷：或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或其多晶型，其中B，Z和PD如本文所述。

公开(公告)号：US10231986B2

公开(公告)日：2019-03-19

申请号：US14866759

申请日：2015-09-25

申请人： Centre National De La Recherche Scientifique ,  Universite Montpellier 2 Sciences Et Techniques ,  Idenix Pharmaceuticals LLC

发明人： David Dukhan ,  Christophe Claude Parsy ,  Gilles Gosselin ,  Jean-François Griffon ,  Guillaume Brandt ,  Cyril B. Dousson ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  Alistar James Stewart

IPC分类号： C07H19/073 ,  C07H19/10 ,  C07H19/173 ,  C07H19/20 ,  A61K31/7072 ,  C07H17/02 ,  A61K31/7068 ,  A61K45/06 ,  A61K9/00 ,  A61K31/7076

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-cyano, azido or amino nucleosides according to Formula 1001 or 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein Base, W, R1 and R2 are as described herein.

公开(公告)号：US09211300B2

公开(公告)日：2015-12-15

申请号：US14109463

申请日：2013-12-17

申请人： IDENIX PHARMACEUTICALS, INC. ,  Centre National De La Recherche Scientifique ,  Université Montpellier 2 Sciences et Techniques

发明人： Benjamin Alexander Mayes ,  Adel M. Moussa ,  Alistair James Stewart ,  Gilles Gosselin

IPC分类号： C07H19/00 ,  A61K31/70 ,  C07H19/10 ,  C07H19/20 ,  C07H19/213 ,  A61K31/708 ,  A61K31/7072 ,  A61K45/06 ,  C07H17/02 ,  C07H19/06 ,  C07H19/16 ,  A61K38/21 ,  A61K31/403 ,  A61K31/497 ,  A61K31/7056

CPC分类号： A61K31/708 ,  A61K31/403 ,  A61K31/497 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07H17/02 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H19/213 ,  A61K2300/00

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, PD, RA, RB, RC, L, M and Z are as described herein.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，化合物根据式1501：或其药学上可接受的盐，溶剂化物，立体异构形式，互变异构形式或多晶型，其中B，PD，RA，RB，RC，L，M和Z如本文所述 。

公开(公告)号：US10513534B2

公开(公告)日：2019-12-24

申请号：US14047862

申请日：2013-10-07

申请人： IDENIX PHARMACEUTICALS LLC ,  Centre National De La Recherche Scientifique ,  UNIVERSITE DE MONTPELLIER

发明人： Gilles Gosselin ,  Christophe Claude Parsy ,  Francois-Rene Alexandre ,  Houcine Rahali ,  Jean-Francois Griffon ,  Dominique Surleraux ,  Cyril B. Dousson ,  Claire Pierra ,  Adel M. Moussa ,  Benjamin Alexander Mayes ,  Alistair James Stewart

IPC分类号： C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/11 ,  C07H19/16 ,  C07H19/173 ,  C07H19/20 ,  C07H19/213 ,  A61K31/7072 ,  A61K45/06 ,  A61K38/21 ,  A61K31/7076 ,  C07H19/14 ,  A61K31/7064 ,  C07H19/12 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/708 ,  A61K31/403 ,  A61K31/497 ,  A61K31/7105 ,  C07H19/23

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.

公开(公告)号：US10238680B2

公开(公告)日：2019-03-26

申请号：US14954815

申请日：2015-11-30

申请人： IDENIX PHARMACEUTICALS LLC ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER

发明人： Benjamin Alexander Mayes ,  Adel M. Moussa ,  Cyril B. Dousson ,  Gilles Gosselin ,  Claire Pierra ,  David Dukhan

IPC分类号： C07H19/10 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  A61K9/00

摘要： Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.

公开(公告)号：US20140086873A1

公开(公告)日：2014-03-27

申请号：US14038617

申请日：2013-09-26

申请人： IDENIX PHARMACEUTICALS, INC.

发明人： Benjamin Alexander Mayes ,  Adel M. Moussa

IPC分类号： A61K31/7076 ,  A61K45/06 ,  C07H17/02

CPC分类号： A61K31/7076 ,  A61K31/403 ,  A61K31/497 ,  A61K31/7056 ,  A61K31/708 ,  A61K38/212 ,  A61K45/06 ,  C07H17/02 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  A61K2300/00

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, provided herein are compounds according to Formula 1001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, Y, Z, A, RC and RD are as described herein.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。 在某些实施方案中，本文提供了根据式1001的化合物：或其药学上可接受的盐，溶剂化物，立体异构体形式，互变异构形式或多晶型物，其中碱，Y，Z，A，RC和RD如本文所述。

公开(公告)号：US09339541B2

公开(公告)日：2016-05-17

申请号：US14195635

申请日：2014-03-03

申请人： IDENIX PHARMACEUTICALS, INC.

发明人： Cyril B. Dousson ,  Benjamin Alexander Mayes ,  David Dukhan ,  Adel M. Moussa ,  Alistair James Stewart

IPC分类号： C07H19/10 ,  C07H19/11 ,  C07H19/20 ,  C07H19/213 ,  A61K45/06 ,  A61K31/7076 ,  A61K31/7072 ,  A61K31/708 ,  C07H19/16 ,  C07H19/06 ,  C07H19/207

CPC分类号： A61K45/06 ,  A61K31/7072 ,  A61K31/7076 ,  A61K31/708 ,  C07H19/06 ,  C07H19/10 ,  C07H19/11 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07H19/213 ,  Y02A50/389

摘要： Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, the compounds are according to Formula 2001: where PD, Base, RA and RB are as provided herein. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

摘要翻译： 本文提供了用于治疗黄病毒科感染（包括HCV感染）的化合物，组合物和方法。 在某些实施方案中，化合物根据式2001：其中PD，碱基，RA和RB如本文所提供。 在某些实施方案中，公开了核苷衍生物的化合物和组合物，其可以单独施用或与其它抗病毒剂组合施用。

公开(公告)号：US20160082030A1

公开(公告)日：2016-03-24

申请号：US14954815

申请日：2015-11-30

申请人： Idenix Pharmaceuticals, Inc.

发明人： Benjamin Alexander Mayes ,  Adel M. MOUSSA ,  Cyril B. DOUSSON ,  Gilles GOSSELIN ,  Claire PIERRA ,  David DUKHAN

IPC分类号： A61K31/7068 ,  A61K31/7072 ,  A61K9/00 ,  C07H19/10 ,  A61K45/06

CPC分类号： A61K31/7068 ,  A61K9/0053 ,  A61K31/7072 ,  A61K45/06 ,  C07H19/10

摘要： Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.