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公开(公告)号：US11524301B2
公开(公告)日：2022-12-13
申请号：US16738944
申请日：2020-01-09
Applicant: Cepheid
Inventor： Douglas B Dority , Tien Phan , David Fromm , Richard J. Casler, Jr. , Dustin Dickens , Stuart Morita , Matthew Piccini
Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.
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公开(公告)号：US11740256B2
公开(公告)日：2023-08-29
申请号：US16577650
申请日：2019-09-20
Applicant: Cepheid
Inventor： Douglas B Dority , Jonathan Siegrist , Ronald Chang
CPC classification number: G01N35/1097 , B01L3/502 , B01L2200/04 , B01L2200/10 , B01L2300/06 , B01L2300/0627 , B01L2300/0809 , B01L2300/12 , B01L2400/06
Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.
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公开(公告)号：US20180031592A1
公开(公告)日：2018-02-01
申请号：US15718840
申请日：2017-09-28
Applicant: Cepheid
Inventor： Douglas B Dority
CPC classification number: G01N35/1095 , B01L3/502 , B01L3/502715 , B01L3/561 , B01L3/563 , B01L2200/026 , G01N35/10 , G01N2035/00326
Abstract: A fluidic bridge device for transport of a fluid sample between a first sample processing device and a second sample processing device. The fluidic bridge may include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the first and second sample processing device. In one aspect the first device is a sample preparation device and the second device is an assay device. The fluidic bridge can include at least two fluid conduits, at least one for transport of the prepared sample, and at least one other to facilitate displacement of air to allow flow of the prepared sample through the other fluid conduit. The fluid channels can include one or more of an amplification chamber, a processing chamber, a gas-permeable vent, a bubble trap, a filter, and an external port. Methods of preparing and transporting a fluid sample between devices are provided herein.
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公开(公告)号：US10767226B2
公开(公告)日：2020-09-08
申请号：US16230458
申请日：2018-12-21
Applicant: Cepheid
Inventor： Yuh-Min Chiang , Douglas B Dority , Dustin Dickens , Jennifer Glass , Reuel Van Atta
IPC: C12Q1/6876 , B01L3/00 , B01L7/00
Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
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