公开(公告)号：US20070132998A1

公开(公告)日：2007-06-14

申请号：US10577597

申请日：2004-10-28

Applicant: Cha-Min Tang ,  Andrew Bartfay-Szabo

Inventor： Cha-Min Tang ,  Andrew Bartfay-Szabo

IPC: G01N21/64

CPC classification number: G01N21/6458 ,  G01N2201/0635

Abstract: A device for discriminately illuminating a sample (22) to be viewed with excitation light (70). For example, an image taken with a CCD (10) provides feedback which is used to modulate the output of an excitation light source (40), thereby allowing a sample (22) to be viewed within the optimal range of detection for the particular CCD device (10) being used, despite the potential of wide dynamic ranges of sample luminescence.

Abstract translation: 一种用于用激发光（70）来区分地照亮待观察的样品（22）的装置。 例如，用CCD（10）拍摄的图像提供用于调制激发光源（40）的输出的反馈，从而允许在针对特定CCD的最佳检测范围内观察样品（22） 使用器件（10），尽管具有宽的动态范围的样品发光的潜力。

公开(公告)号：US07532323B2

公开(公告)日：2009-05-12

申请号：US10577597

申请日：2004-10-28

Applicant: Cha-Min Tang ,  Andrew Bartfay-Szabo

Inventor： Cha-Min Tang ,  Andrew Bartfay-Szabo

IPC: G01J3/30

CPC classification number: G01N21/6458 ,  G01N2201/0635

Abstract: A device for discriminately illuminating a sample (22) to be viewed with excitation light (70). For example, an image taken with a CCD (10) provides feedback which is used to modulate the output of an excitation light source (40), thereby allowing a sample (22) to be viewed within the optimal range of detection for the particular CCD device (10) being used, despite the potential of wide dynamic ranges of sample luminescence.

Abstract translation: 一种用于用激发光（70）来区分地照亮待观察的样品（22）的装置。 例如，用CCD（10）拍摄的图像提供用于调制激发光源（40）的输出的反馈，从而允许在针对特定CCD的最佳检测范围内观察样品（22） 使用器件（10），尽管具有宽的动态范围的样品发光的潜力。

公开(公告)号：US20090264981A1

公开(公告)日：2009-10-22

申请号：US12303716

申请日：2007-06-07

Applicant: Robert Poston ,  Cha-Min Tang

Inventor： Robert Poston ,  Cha-Min Tang

IPC: A61F2/06 ,  A61B6/00

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B17/06166 ,  A61B17/11 ,  A61B90/39

Abstract: Methods comprising the use of optical coherence tomography to examine a harvested conduit for its suitability for grafting, to examine a candidate conduit prior to harvesting for coronary artery bypass graftings to assess the quality of an anastomosis, to assess the quality of the suturing of a small vessel or duct with a suture coated with a contrast agent, and to detect coronary artery disease in a harvested donor heart prior to transplantation.

Abstract translation: 方法包括使用光学相干断层扫描检查收获的管道是否适合接枝，在收获冠状动脉旁路移植术之前检查候选导管以评估吻合质量，以评估缝合的质量 容器或导管，其中涂有造影剂的缝合线，并在移植前检测收获的供体心脏中的冠状动脉疾病。

公开(公告)号：US07197193B2

公开(公告)日：2007-03-27

申请号：US10429258

申请日：2003-05-05

Applicant: Shuhong Li ,  Cha-Min Tang ,  Cha-Mei Tang

Inventor： Shuhong Li ,  Cha-Min Tang ,  Cha-Mei Tang

IPC: G06K9/36

CPC classification number: G06T7/55 ,  G06T2207/10056 ,  G06T2207/30024

Abstract: An instrument to acquire and methods to obtain three-dimensional (3D) images from a series of two-dimensional (2D) images which are obtained without moving the relative positions of the target, the detector, or the focusing lens is disclosed. The 2D images consist of one centered image obtained with the aperture at the center of optical system, and at least two directional images obtained with apertures at off-axis locations. The images can be obtained simultaneously or sequentially. The blurred 2D images are sectioned by computational method using point spread function of the optical system resulting in a set of decoupled 2D layers of the 3D object. The layered images are then sharpened by deconvolution using point spread function. The 3D reconstructed image is displayed. This technique provides fast data acquisition and fast image reconstruction and eliminates problems associated with motion, phototoxicity and photobleaching.

Abstract translation: 公开了一种用于获取并从一系列二维（2D）图像中获得三维（3D）图像的仪器，该方法在不移动目标，检测器或聚焦透镜的相对位置的情况下获得。 2D图像由在光学系统的中心处的孔径获得的一个中心图像和在离轴位置处具有孔径获得的至少两个定向图像组成。 图像可以同时或顺序获得。 通过使用光学系统的点扩散函数的计算方法对模糊的2D图像进行分割，得到3D对象的一组去耦2D层。 然后通过使用点扩散函数的去卷积来锐化分层图像。 显示3D重建图像。 该技术提供快速数据采集和快速图像重建，并消除与运动，光毒性和光漂白相关的问题。

公开(公告)号：US6154282A

公开(公告)日：2000-11-28

申请号：US374535

申请日：1999-08-16

Applicant: Lothar Lilge ,  Peter S. Pennefather ,  Stephen M. Ross ,  Cha-Min Tang ,  Kai Zhang

Inventor： Lothar Lilge ,  Peter S. Pennefather ,  Stephen M. Ross ,  Cha-Min Tang ,  Kai Zhang

IPC: G01N21/64 ,  G02B21/00 ,  G02B21/06 ,  H01L33/64

CPC classification number: G02B21/0096

Abstract: Apparatus for exciting a fluorescent or phosphorescent molecule applied to a specimen in a microscope, the molecule having a known excitation wavelength, comprises a semiconductor light source capable of emitting an output light within a preselected wavelength band correlated with the excitation wavelength of the molecule, an electronic controller coupled to the light source for controlling the intensity of the output light, and an optical system for converting the output light into an excitation beam having a pre-selected distribution of light flux suitable for illuminating the specimen. The semiconductor light source is preferably a light emitting diode or superluminescent diode. The subject invention provides for a fluorescence excitation illuminator having a long lifetime and relatively low cost. Intensity modulation or attenuation can be achieved electronically, without the need for shutters.

Abstract translation: 用于激发在显微镜中施加到样品上的荧光或磷光分子的装置，具有已知激发波长的分子包括能够发射与分子的激发波长相关的预选波长带内的输出光的半导体光源， 耦合到光源的电子控制器，用于控制输出光的强度;以及光学系统，用于将输出光转换成具有预先选择的适于照射样本的光通量分布的激发光束。 半导体光源优选为发光二极管或超发光二极管。 本发明提供了具有长寿命和相对较低成本的荧光激发照明器。 强度调制或衰减可以电子地实现，而不需要百叶窗。

公开(公告)号：US4894376A

公开(公告)日：1990-01-16

申请号：US160835

申请日：1988-02-26

Applicant: Martin Morad ,  Cha-Min Tang

Inventor： Martin Morad ,  Cha-Min Tang

IPC: A61K31/495

CPC classification number: A61K31/495

Abstract: The invention provides methods of treating diseases characterized by hyperexcitability of neurons. An amount of a substituted pyrazinoylguanidine compound effective to regulate excitability of the neurons is administered. Substituted pyrazinoylguanidines having the formula ##STR1## wherein R is halogen and R.sup.1 is a member of the group consisting of hydrogen, benzyl and optionally substituted benzyl are useful in the invention. The invention also discloses a method of treating neurons having hyperexcitable cell membranes.

Abstract translation: 本发明提供治疗以神经元兴奋性特征为特征的疾病的方法。 施用一定量的有效调节神经元兴奋性的取代的吡嗪基胍化合物。 具有式“IMAGE”的取代的吡嗪酰基胍其中R是卤素，R 1是氢，苄基和任选取代的苄基的成员，可用于本发明。 本发明还公开了一种治疗具有过度兴奋性细胞膜的神经细胞的方法。