公开(公告)号：US07565208B2

公开(公告)日：2009-07-21

申请号：US11037342

申请日：2005-01-19

申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney

IPC分类号： A61N1/02

CPC分类号： A61B5/4839 ,  A61B5/0422 ,  A61B5/0538 ,  A61B5/6885 ,  A61M25/0084

摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.

摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

公开(公告)号：US07699829B2

公开(公告)日：2010-04-20

申请号：US11037154

申请日：2005-01-19

申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney ,  Toby Freyman

发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley ,  Dorin Panescu ,  Maria Palasis ,  Jacob Rooney ,  Toby Freyman

IPC分类号： A61M31/00

CPC分类号： A61B5/0422 ,  A61B5/6852 ,  A61B2018/00875 ,  A61B2018/1425 ,  A61B2218/002 ,  A61M25/0084 ,  A61M25/0136 ,  A61M2025/0096 ,  A61N1/0568

摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.

摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。

公开(公告)号：US07678077B2

公开(公告)日：2010-03-16

申请号：US10781775

申请日：2004-02-20

申请人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley

发明人： Chad G. Harris ,  Matthew L. Hawk ,  Timothy J. Mickley

IPC分类号： A61M5/00

CPC分类号： A61M25/0606 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0084 ,  A61M2025/0089

摘要： An apparatus for the injection of therapeutic and other agents at a target site within a patient's body. A catheter including a first elongated shaft having a distal end and a proximal end and a lumen extending therebetween. The catheter also including a second elongated shaft slidingly disposed in the first elongated shaft, the second elongated shaft having a distal end and a proximal and a lumen extending therebetween. The catheter further including a third elongated shaft disposed in and attached to the second elongate shaft, the third elongated shaft to move in a one-to-one relationship with the first elongated shaft and the second elongated shaft to maintain a predetermined needle deployment length as each are subjected to various bend configurations.

摘要翻译： 用于在患者体内的靶位置注射治疗剂和其它药剂的装置。 一种导管，其包括具有远端和近端的第一细长轴和在其间延伸的内腔。 导管还包括滑动地设置在第一细长轴中的第二细长轴，第二细长轴具有远端和近端以及在其间延伸的内腔。 所述导管还包括设置在所述第二细长轴中并连接到所述第二细长轴的第三细长轴，所述第三细长轴与所述第一细长轴和所述第二细长轴以一对一关系移动，以将预定的针展开长度保持为 每个都经受各种弯曲构造。

公开(公告)号：US07938799B2

公开(公告)日：2011-05-10

申请号：US11780885

申请日：2007-07-20

申请人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

发明人： Samuel J. Epstein ,  Toby Freyman ,  Chad G. Harris ,  Timothy J. Mickley

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

公开(公告)号：US06264630B1

公开(公告)日：2001-07-24

申请号：US09219802

申请日：1998-12-23

申请人： Timothy J. Mickley ,  Chad G. Harris

发明人： Timothy J. Mickley ,  Chad G. Harris

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61B17/22012 ,  A61M25/0043 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/1079 ,  A61M2025/1093

摘要： A catheter is disclosed which includes an over-the-wire type balloon catheter, with a guide wire, wherein the catheter incorporates an axially movable inner tubular member which extends proximally through a proximal manifold lumen. The inner tubular member extends distally beyond the distal end of the outer tubular member with the balloon member distal waist affixed to the inner tubular member proximate the distal end. The catheter incorporates axial tension members which function to transmit force to the distal tip when the movable inner tubular member is oscillated axially. The axial tension members are preferably a plurality of wires, each having a proximal end affixed to the outside diameter of the inner tubular member proximate the manifold, and each having a distal end affixed to the outside diameter of the inner tubular member a substantial distance distal of the manifold. When the inner tubular member is pulled proximally, energy is stored in the catheter, which when the inner is released, forces the distal tip forward with added force from the distal point of attachment of the axial tension members. An actuator and a valve assembly are preferably included.

摘要翻译： 公开了一种导管，其包括具有导丝的超线型气囊导管，其中所述导管包括沿近侧延伸通过近端歧管内腔的可轴向移动的内部管状构件。 内部管状构件向远侧延伸超过外部管状构件的远端，球囊构件远端腰部靠近远端固定到内部管状构件。 该导管包括轴向张力构件，当可移动的内部管状构件轴向摆动时，该张力构件用于将力传递到远侧末端。 轴向张力构件优选地是多个线，每个线具有固定到靠近歧管的内部管状构件的外径的近端，并且每个具有固定到内部管状构件的外径的远端，远端远离 的歧管。 当内部管状构件被向近侧拉动时，能量被存储在导管中，当内部被释放时，其能够通过来自轴向张力构件的远端附接点的附加力向前推动远侧末端。 优选地包括致动器和阀组件。

公开(公告)号：US5961536A

公开(公告)日：1999-10-05

申请号：US950520

申请日：1997-10-14

申请人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

发明人： Timothy J. Mickley ,  Steven P. Mertens ,  Christopher R. Larson ,  Chad G. Harris ,  John H. Carlson, II

IPC分类号： A61F2/958 ,  A61M25/10

CPC分类号： A61M25/10 ,  A61M2025/1068

摘要： A variable length balloon catheter is provided. The balloon catheter includes a catheter shaft having a distal portion, a balloon and an adjustment device. The balloon is in fluid communication with a distal end of the catheter shaft. The adjustment device includes an outer sleeve and an attachment structure. The outer sleeve is configured to be generally co-axially received over the distal portion of the catheter shaft and includes a distal end configured to restrict inflation proximal the distal end. Further, the outer sleeve is configured such that at least a portion of the outer sleeve is slidable relative to the distal portion of the catheter shaft such that a distal end of the outer sleeve relative to the balloon can be varied. The attachment structure is similarly disposed at the distal portion of the catheter shaft and is configured to selectively secure at least a portion of the outer sleeve to the distal portion of the catheter shaft such that the outer sleeve will not move upon inflation of the balloon.

摘要翻译： 提供可变长度的球囊导管。 气囊导管包括具有远端部分的导管轴，球囊和调节装置。 气囊与导管轴的远端流体连通。 调节装置包括外套筒和附接结构。 外套管被构造成大致同轴地容纳在导管轴的远侧部分上，并且包括构造成限制近端近端的充气的远端。 此外，外套筒构造成使得外套筒的至少一部分相对于导管轴的远端部分可滑动，使得外套筒相对于球囊的远端可以改变。 附接结构类似地设置在导管轴的远端部分处，并被构造成选择性地将外套筒的至少一部分固定到导管轴的远端部分，使得外套筒在气囊膨胀时不会移动。

公开(公告)号：US08808364B2

公开(公告)日：2014-08-19

申请号：US13240792

申请日：2011-09-22

申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

IPC分类号： A61F2/06 ,  A61M29/00

CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

公开(公告)号：US20120010589A1

公开(公告)日：2012-01-12

申请号：US13240792

申请日：2011-09-22

申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

IPC分类号： A61M5/00

CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

公开(公告)号：US07686788B2

公开(公告)日：2010-03-30

申请号：US11070190

申请日：2005-03-03

申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy J. Mickley

发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy J. Mickley

IPC分类号： A61M5/00

CPC分类号： A61M25/0082 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  A61M5/1483 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0091

摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

公开(公告)号：US20090131906A1

公开(公告)日：2009-05-21

申请号：US12358337

申请日：2009-01-23

申请人： Toby FREYMAN ,  Maria Palasis ,  Timothy J. Mickley

发明人： Toby FREYMAN ,  Maria Palasis ,  Timothy J. Mickley

IPC分类号： A61M25/10

CPC分类号： A61M25/1006 ,  A61B17/12136 ,  A61B2017/22067 ,  A61M25/0032 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0076 ,  A61M2025/0175 ,  A61M2025/1015 ,  A61M2025/1052

摘要： A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic.

摘要翻译： 提供了用于将治疗剂递送到目标位置的治疗性递送导管系统方法或试剂盒。 在本发明的各种实施例中，本发明可以包括具有治疗性输送腔和治疗性输送孔的导管。 管腔和孔可以彼此流体连通，并且可以被配置成使得通过其传递的治疗可以在模拟接收治疗剂的目标位置处存在或以其他方式正常的压力下进行。 在一些实施例中，导管可以是套件的一部分，其可以包括关于导管的适当操作方式的指令。 这些说明书可以包括用于治疗性递送以及递送时间的建议目标压力，以及设备在递送之后驻留在目标区域的建议时间长度，以允许治疗剂的适当摄取。