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公开(公告)号：US08808364B2
公开(公告)日：2014-08-19
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US20120010589A1
公开(公告)日：2012-01-12
申请号：US13240792
申请日：2011-09-22
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
IPC分类号： A61M5/00
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US07686788B2
公开(公告)日：2010-03-30
申请号：US11070190
申请日：2005-03-03
申请人： Toby Freyman , Maria Palasis , Wendy Naimark , Timothy J. Mickley
发明人： Toby Freyman , Maria Palasis , Wendy Naimark , Timothy J. Mickley
IPC分类号： A61M5/00
CPC分类号： A61M25/0082 , A61M5/14526 , A61M5/14593 , A61M5/148 , A61M5/1483 , A61M25/0074 , A61M25/0084 , A61M2025/0091
摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.
摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。
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公开(公告)号：US08038709B2
公开(公告)日：2011-10-18
申请号：US12022413
申请日：2008-01-30
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US20080183143A1
公开(公告)日：2008-07-31
申请号：US12022413
申请日：2008-01-30
申请人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
发明人： Maria Palasis , Timothy J. Mickley , Toby Freyman , Wendy Naimark
CPC分类号： A61M31/002 , A61F2/24 , A61F2250/0067
摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.
摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。
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公开(公告)号：US08740844B2
公开(公告)日：2014-06-03
申请号：US10645653
申请日：2003-08-20
CPC分类号： A61M29/02 , A61M25/1029 , A61M2025/0057 , A61M2025/105
摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.
摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。
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公开(公告)号：US20090131906A1
公开(公告)日：2009-05-21
申请号：US12358337
申请日：2009-01-23
申请人： Toby FREYMAN , Maria Palasis , Timothy J. Mickley
发明人： Toby FREYMAN , Maria Palasis , Timothy J. Mickley
IPC分类号： A61M25/10
CPC分类号： A61M25/1006 , A61B17/12136 , A61B2017/22067 , A61M25/0032 , A61M25/0045 , A61M25/1002 , A61M2025/0004 , A61M2025/0034 , A61M2025/0076 , A61M2025/0175 , A61M2025/1015 , A61M2025/1052
摘要： A therapeutic delivery catheter system method or kit for delivery of therapeutic to a target location is provided. In various embodiments of the present invention the invention may include a catheter with a therapeutic delivery lumen and a therapeutic delivery orifice. The lumen and the orifice may be in fluid communication with each other and may be configured such that therapeutic delivered therethrough may be done at pressures mimicking pressures existing or otherwise normal at the target locations receiving the therapeutic. In some embodiments the catheter may be part of a kit that may include instructions regarding the proper manner of operation of the catheter. These instructions may include suggested target pressures for therapeutic delivery as well as delivery times, and suggested lengths of time for the device to reside at the target area after delivery to allow for proper uptake of the therapeutic.
摘要翻译： 提供了用于将治疗剂递送到目标位置的治疗性递送导管系统方法或试剂盒。 在本发明的各种实施例中，本发明可以包括具有治疗性输送腔和治疗性输送孔的导管。 管腔和孔可以彼此流体连通，并且可以被配置成使得通过其传递的治疗可以在模拟接收治疗剂的目标位置处存在或以其他方式正常的压力下进行。 在一些实施例中，导管可以是套件的一部分，其可以包括关于导管的适当操作方式的指令。 这些说明书可以包括用于治疗性递送以及递送时间的建议目标压力，以及设备在递送之后驻留在目标区域的建议时间长度，以允许治疗剂的适当摄取。
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公开(公告)号：US07699829B2
公开(公告)日：2010-04-20
申请号：US11037154
申请日：2005-01-19
申请人： Chad G. Harris , Matthew L. Hawk , Timothy J. Mickley , Dorin Panescu , Maria Palasis , Jacob Rooney , Toby Freyman
发明人： Chad G. Harris , Matthew L. Hawk , Timothy J. Mickley , Dorin Panescu , Maria Palasis , Jacob Rooney , Toby Freyman
IPC分类号： A61M31/00
CPC分类号： A61B5/0422 , A61B5/6852 , A61B2018/00875 , A61B2018/1425 , A61B2218/002 , A61M25/0084 , A61M25/0136 , A61M2025/0096 , A61N1/0568
摘要： An apparatus and method for catheter-based sensing and injection at a target site within a patient's body. An injection catheter is equipped with electrodes at its distal end which contact the surface of a target site, such as an AV node of the heart. Electrical signals detected at the target site by the electrodes are fed via leads to the proximal end of the catheter, where they are received by a monitor, such as an EKG monitor. If the electrical signals satisfy predetermined criteria, a needle within the catheter is extended into the target site, and a therapeutic agent is injected into the target site.
摘要翻译： 一种用于在患者体内的目标部位进行基于导管的感测和注射的装置和方法。 注射导管在其远端配备有电极，其接触目标部位的表面，例如心脏的AV节点。 通过电极在目标部位检测到的电信号通过引线馈送到导管的近端，在那里它们被诸如EKG监视器的监视器接收。 如果电信号满足预定标准，则导管内的针头延伸到目标部位，并将治疗剂注射到目标部位。
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公开(公告)号：US07470252B2
公开(公告)日：2008-12-30
申请号：US10942046
申请日：2004-09-16
申请人： Timothy J. Mickley , Maria Palasis , Toby Freyman
发明人： Timothy J. Mickley , Maria Palasis , Toby Freyman
CPC分类号： A61M25/104 , A61M25/10 , A61M2025/105 , A61M2025/1072
摘要： The present invention provides a systems that delivers therapeutic to the inner lumens, chambers, cavities, and vessels of the body. A therapeutic delivery device for delivery of therapeutic to a target site within the body of a patient is provided. This device may include a catheter, an expandable multi-port housing fluidly coupled to the catheter and a sheath. The multi-port housing in this device may be sized to travel within a lumen of a patient and may be adapted to expand from a first configuration to a second configuration. The multi-port housing may also contain at least two ejection ports coupled to an internal lumen of the multi-port housing.
摘要翻译： 本发明提供了将治疗剂递送到身体的内腔，腔室，空腔和血管的系统。 提供了用于将治疗剂递送到患者体内的靶位点的治疗递送装置。 该装置可以包括导管，可流体地联接到导管的可扩展多端口壳体和护套。 该装置中的多端口壳体的尺寸可以设计成在患者的内腔内行进，并且可以适于从第一构型扩展到第二构造。 多端口壳体还可以包含联接到多端口壳体的内腔的至少两个喷射端口。
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公开(公告)号：US07758587B2
公开(公告)日：2010-07-20
申请号：US10680288
申请日：2003-10-08
申请人： Toby Freyman , Timothy J. Mickley
发明人： Toby Freyman , Timothy J. Mickley
IPC分类号： A61F4/00
CPC分类号： A61M25/01 , A61B5/061 , A61M25/0105
摘要： A system and method for simply and reliably determining the location and orientation of a medical device within a patient's body. A medical device, such as a catheter, has bending indicators on or imbedded in its wall, and passes through an anatomical reference of known orientation relative to a target site within the patient. Information from the tube bending indicators permits determination of the orientation of a feature, such as an orifice, at the distal end of the medical device relative to the anatomical reference. From the known orientation of the anatomical reference, and information on the location and orientation of the distal end of the medical device obtained from fluoroscopic imaging from a single direction, the physician may reliably determine the orientation of the distal feature relative to the target site, eliminating the need for imaging from multiple directions.
摘要翻译： 一种用于简单且可靠地确定患者体内的医疗装置的位置和方向的系统和方法。 诸如导管的医疗装置在其壁上具有或嵌入其中的弯曲指示器，并且相对于患者内的目标部位通过已知取向的解剖参考。 来自管弯曲指示器的信息允许在医疗装置的远端处相对于解剖参考确定诸如孔的特征的取向。 从已知的解剖学参考方向，以及关于从单一方向从透视成像获得的医疗装置的远端的位置和方位的信息，医师可以可靠地确定远侧特征相对于目标部位的方向， 消除了从多个方向进行成像的需要。
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