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1.发明授权Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same 有权具有增强的肿瘤特异性和强度的修饰的叔启动子和包含其的重组载体公开(公告)号：US08067567B2
公开(公告)日：2011-11-29
申请号：US10547233
申请日：2004-02-27
申请人： Chae-Ok Yun , Joo-Hang Kim , Jai-Myung Yang
发明人： Chae-Ok Yun , Joo-Hang Kim , Jai-Myung Yang
CPC分类号： C12N15/86 , A61K38/45 , A61K48/00 , C12N9/1276 , C12N2710/10343 , C12N2830/008 , C12N2830/85
摘要： The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional regulatory sequence comprising a human telomere reverse transcriptase (hTERT) promoter linked to a nucleotide sequence that comprises one or more c-Myc binding sites and/or one or more Sp1 binding sites, and a recombinant vector comprising a certain gene that is operably linked to the above transcriptional regulatory sequence.
摘要翻译： 本发明涉及具有增强的肿瘤特异性和强度的转录调节序列和包含转录调节序列的重组载体。 更具体地，本发明涉及包含与包含一个或多个c-Myc结合位点和/或一个或多个Sp1结合位点的核苷酸序列连接的人端粒逆转录酶（hTERT）启动子的转录调节序列，以及重组 载体包含与上述转录调控序列有效连接的某个基因。
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2.发明申请Modified tert promoter with enhanced tumor-specificity and strength and recombinant vector comprising the same 有权具有增强的肿瘤特异性和强度的修饰的叔启动子和包含其的重组载体公开(公告)号：US20070059287A1
公开(公告)日：2007-03-15
申请号：US10547233
申请日：2004-02-27
申请人： Chae-Ok Yun , Joo-Hang Kim , Jai-Myung Yang
发明人： Chae-Ok Yun , Joo-Hang Kim , Jai-Myung Yang
IPC分类号： A61K48/00 , C12N5/08 , C12N15/861
CPC分类号： C12N15/86 , A61K38/45 , A61K48/00 , C12N9/1276 , C12N2710/10343 , C12N2830/008 , C12N2830/85
摘要： The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional regulatory sequence comprising a human telomere reverse transcriptase (hTERT) promoter linked to a nucleotide sequence that comprises one or more c-Myc binding sites and/or one or more Sp1 binding sites, and a recombinant vector comprising a certain gene that is operably linked to the above transcriptional regulatory sequence.
摘要翻译： 本发明涉及具有增强的肿瘤特异性和强度的转录调节序列和包含转录调节序列的重组载体。 更具体地，本发明涉及包含与包含一个或多个c-Myc结合位点和/或一个或多个Sp1结合位点的核苷酸序列连接的人端粒逆转录酶（hTERT）启动子的转录调节序列，以及重组 载体包含与上述转录调控序列有效连接的某个基因。
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公开(公告)号：US09468690B2
公开(公告)日：2016-10-18
申请号：US11816751
申请日：2006-02-24
申请人： Chae-Ok Yun , Joo-Hang Kim
发明人： Chae-Ok Yun , Joo-Hang Kim
CPC分类号： A61K48/005 , A61K38/162 , C07K14/005 , C07K14/70578 , C12N7/00 , C12N2710/10033 , C12N2799/022
摘要： A novel gene delivery system and recombinant adenovirus includes a decorin-encoding sequence to enhance transduction efficiency of transgenes. A pharmaceutical anti-tumor composition includes the recombinant adenovirus, as well as a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.
摘要翻译： 一种新的基因递送系统和重组腺病毒包括一个核心蛋白聚糖编码序列，以增强转基因的转导效率。 药物抗肿瘤组合物包括重组腺病毒，以及具有改善的组织穿透能力的药物组合物和用于治疗与过量细胞外基质的积累相关的疾病或病症的药物组合物。
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4.发明申请Gene Delivery System Containing Relaxin Gene And Pharmaceutical Composition Using Relaxin 审中-公开含有松弛素基因和使用松弛素的药物组合物的基因递送系统公开(公告)号：US20070202080A1
公开(公告)日：2007-08-30
申请号：US10599521
申请日：2005-03-30
申请人： Chae-Ok Yun , Joo-Hang Kim
发明人： Chae-Ok Yun , Joo-Hang Kim
IPC分类号： A61K48/00 , C12N15/861 , A61K9/127 , C12N15/88
CPC分类号： C12N15/86 , A61K38/2221 , A61K48/00 , A61K48/005 , C12N2710/10043 , C12N2710/10332 , C12N2710/10343
摘要： The present invention relates to a novel gene delivery system and recombinant adenovirus comprising the relaxin-encoding sequence to enhance transduction efficiency of transgenes, a pharmaceutical anti-tumor composition comprising the recombinant adenovirus, a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.
摘要翻译： 本发明涉及一种新的基因递送系统和重组腺病毒，其包含用于增强转基因转导效率的松弛素编码序列，包含重组腺病毒的药物抗肿瘤组合物，具有改善的组织穿透能力的药物组合物和用于 治疗与过量细胞外基质的积累相关的疾病或病症。
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公开(公告)号：US09850500B2
公开(公告)日：2017-12-26
申请号：US12223166
申请日：2006-05-30
申请人： Chae-Ok Yun , Joo-Hang Kim , Jin Soo Kim , Hyun Chul Shin , Yoon A Kang
发明人： Chae-Ok Yun , Joo-Hang Kim , Jin Soo Kim , Hyun Chul Shin , Yoon A Kang
CPC分类号： C12N15/86 , A61K48/005 , C12N2710/10343
摘要： The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral UR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.
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6.发明申请Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus 有权具有增强的治疗效果的重组腺病毒和包含所述重组腺病毒的药物组合物公开(公告)号：US20050002965A1
公开(公告)日：2005-01-06
申请号：US10491313
申请日：2002-09-28
申请人： Chae-Ok Yun , Joo-Hang Kim
发明人： Chae-Ok Yun , Joo-Hang Kim
IPC分类号： C12N15/09 , A61K48/00 , A61P35/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N7/00 , C12N7/01 , C12N15/861 , C12Q1/70 , A61K39/12
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2710/10345
摘要： Disclosed is a recombinant adenovirus with a protein containing a VSV-G epitope derived from vesicular stomatitis virus (VSV). Also, the present invention discloses a pharmaceutical composition comprising such a recombinant adenovirus and a pharmaceutically acceptable carrier. Further, the present invention discloses a recombinant plasmid capable of expressing the recombinant adenovirus and a host cell transformed with the recombinant adenovirus.
摘要翻译： 公开了具有衍生自水泡性口炎病毒（VSV）的VSV-G表位的蛋白质的重组腺病毒。 此外，本发明公开了包含这种重组腺病毒和药学上可接受的载体的药物组合物。 此外，本发明公开了能够表达重组腺病毒的重组质粒和用重组腺病毒转化的宿主细胞。
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7.发明授权Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus 有权具有增强的治疗效果的重组腺病毒和包含所述重组腺病毒的药物组合物公开(公告)号：US09175309B2
公开(公告)日：2015-11-03
申请号：US10491313
申请日：2002-09-28
申请人： Chae-ok Yun , Joo-Hang Kim
发明人： Chae-ok Yun , Joo-Hang Kim
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2710/10345
摘要： Disclosed is a recombinant adenovirus with a protein containing a VSV-G epitope derived from vesicular stomatitis virus (VSV). Also, the present invention discloses a pharmaceutical composition comprising such a recombinant adenovirus and a pharmaceutically acceptable carrier. Further, the present invention discloses a recombinant plasmid capable of expressing the recombinant adenovirus and a host cell transformed with the recombinant adenovirus.
摘要翻译： 公开了具有衍生自水泡性口炎病毒（VSV）的VSV-G表位的蛋白质的重组腺病毒。 此外，本发明公开了包含这种重组腺病毒和药学上可接受的载体的药物组合物。 此外，本发明公开了能够表达重组腺病毒的重组质粒和用重组腺病毒转化的宿主细胞。
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公开(公告)号：US20100215621A1
公开(公告)日：2010-08-26
申请号：US12223166
申请日：2006-05-30
申请人： Chae-Ok Yun , Joo-Hang Kim , Jin Soo Kim , Hyun Chul Shin , Yoon A. Kang
发明人： Chae-Ok Yun , Joo-Hang Kim , Jin Soo Kim , Hyun Chul Shin , Yoon A. Kang
CPC分类号： C12N15/86 , A61K48/005 , C12N2710/10343
摘要： The present invention relates to a recombinant adenovirus capable of regulating angiogenesis, which comprises (a) an adenoviral ITR (inverted terminal repeat) nucleotide sequence; and (b) a transcription regulatory sequence for a VEGF-A (vascular endothelial growth factor-A) gene comprising (i) a nucleotide sequence encoding a DNA binding domain comprising a zinc finger domain to bind to a site in a VEGF-A promoter sequence as set forth in nucleotides 1-2362 of SEQ ID NO:1, and (ii) a transcription activation domain or a transcription inhibitory domain linked to the nucleotide sequence encoding the DNA binding domain; and a pharmaceutical composition comprising the recombinant adenovirus.
摘要翻译： 本发明涉及能够调节血管生成的重组腺病毒，其包含（a）腺病毒ITR（反向末端重复）核苷酸序列; （b）VEGF-A（血管内皮生长因子-A）基因的转录调控序列，其包含（i）编码包含锌指结构域的DNA结合域的核苷酸序列以结合VEGF-A启动子中的位点 序列，如SEQ ID NO：1的核苷酸1-2362所示，和（ii）与编码DNA结合结构域的核苷酸序列连接的转录活化结构域或转录抑制结构域; 和包含重组腺病毒的药物组合物。
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公开(公告)号：US20080132449A1
公开(公告)日：2008-06-05
申请号：US11816751
申请日：2006-02-24
申请人： Chae-Ok Yun , Joo-Hang Kim
发明人： Chae-Ok Yun , Joo-Hang Kim
CPC分类号： A61K48/005 , A61K38/162 , C07K14/005 , C07K14/70578 , C12N7/00 , C12N2710/10033 , C12N2799/022
摘要： A novel gene delivery system and recombinant adenovirus includes a decorin-encoding sequence to enhance transduction efficiency of transgenes. A pharmaceutical anti-tumor composition includes the recombinant adenovirus, as well as a pharmaceutical composition having improved tissue penetration potency and a pharmaceutical composition for treating a disease or disorder associated with accumulation of excess extracellular matrix.
摘要翻译： 一种新的基因递送系统和重组腺病毒包括一个核心蛋白聚糖编码序列，以增强转基因的转导效率。 药物抗肿瘤组合物包括重组腺病毒，以及具有改善的组织穿透能力的药物组合物和用于治疗与过量细胞外基质的积累相关的疾病或病症的药物组合物。
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