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公开(公告)号:US06967092B1
公开(公告)日:2005-11-22
申请号:US08957610
申请日:1997-10-24
申请人: John P. Mc Kearn , Charles A. McWherter , Yiqing Feng , Neena L. Summers , Nicholas R. Staten , Philip R. Streeter , Susan L. Woulfe , Nancy I. Minster , John C. Minnerly
发明人: John P. Mc Kearn , Charles A. McWherter , Yiqing Feng , Neena L. Summers , Nicholas R. Staten , Philip R. Streeter , Susan L. Woulfe , Nancy I. Minster , John C. Minnerly
IPC分类号: C07K14/475 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/54 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/62
CPC分类号: C07K14/524 , C07K14/475 , C07K14/505 , C07K14/535 , C07K14/5403 , C07K2319/00
摘要: Disclosed are novel multi-functional chimeric hematopoietic receptor agonist proteins, DNAs which encode the multi-functional chimeric hematopoietic receptor agonist proteins, methods of making the multi-functional chimeric hematopoietic receptor agonist proetiens and methods of using the multi-functional chimeric hematopoietic receptor agonist proteins.
摘要翻译: 公开了新的多功能嵌合造血受体激动剂蛋白质,编码多功能嵌合体造血受体激动剂蛋白质的DNA,制备多功能嵌合体造血受体激动剂前体的方法和使用多功能嵌合造血受体激动剂蛋白质的方法 。
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公开(公告)号:US06660257B1
公开(公告)日:2003-12-09
申请号:US08955090
申请日:1997-10-21
申请人: Charles A. McWherter , Yiqing Feng , John P. Mc Kearn , Nicholas R. Staten , Philip R. Streeter , Susan L. Woulfe , Nancy I. Minster , John C. Minnerly
发明人: Charles A. McWherter , Yiqing Feng , John P. Mc Kearn , Nicholas R. Staten , Philip R. Streeter , Susan L. Woulfe , Nancy I. Minster , John C. Minnerly
IPC分类号: A61K3819
CPC分类号: C07K14/475 , A61K38/00 , A61K48/00
摘要: Disclosed are novel flt-3 receptor agonist proteins, DNAs which encode the flt-3 receptor agonist proteins, methods of making the flt-3 receptor agonist proteins and methods of using the flt-3 receptor agonist proteins.
摘要翻译: 公开了新的flt-3受体激动剂蛋白质,编码flt-3受体激动剂蛋白质的DNA,制备flt-3受体激动剂蛋白质的方法和使用flt-3受体激动剂蛋白质的方法。
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公开(公告)号:US08247186B2
公开(公告)日:2012-08-21
申请号:US13324929
申请日:2011-12-13
IPC分类号: G01N33/567
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子或可检测标记缀合。 这些抗体可用于检测和/或分离胰腺细胞或其子集。 还公开了治疗胰腺肿瘤的方法。
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公开(公告)号:US07981628B2
公开(公告)日:2011-07-19
申请号:US12298761
申请日:2007-04-27
IPC分类号: G01N33/567
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合,例如可检测标记,治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中,分离的单克隆抗体结合胰腺内分泌细胞,可用于检测糖尿病或胰腺内分泌细胞肿瘤。
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公开(公告)号:US20090098140A1
公开(公告)日:2009-04-16
申请号:US12298761
申请日:2007-04-27
申请人: Markus Grompe , Philip R. Streeter , Craig Dorrell , Stephanie L. Abraham , Kelsea M. Lanxon-Cookson
发明人: Markus Grompe , Philip R. Streeter , Craig Dorrell , Stephanie L. Abraham , Kelsea M. Lanxon-Cookson
IPC分类号: A61K39/395 , C07K16/18 , C12N15/11 , G01N33/53 , G01N33/574 , C12N15/00 , C12N5/06
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合,例如可检测标记,治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中,分离的单克隆抗体结合胰腺内分泌细胞,可用于检测糖尿病或胰腺内分泌细胞肿瘤。
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公开(公告)号:US20110165080A1
公开(公告)日:2011-07-07
申请号:US13010737
申请日:2011-01-20
IPC分类号: C07K16/28 , C12N15/13 , C12N15/85 , C12N5/10 , C12N5/12 , G01N33/567 , C12N5/071 , A61K49/00
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合,例如可检测标记,治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中,分离的单克隆抗体结合胰腺内分泌细胞,可用于检测糖尿病或胰腺内分泌细胞肿瘤。
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公开(公告)号:US20120121512A1
公开(公告)日:2012-05-17
申请号:US13324929
申请日:2011-12-13
IPC分类号: C07K16/28 , C07K19/00 , C07H21/04 , A61K39/395 , A61K49/00 , A61P35/00 , C12N15/63 , C12N5/16 , G01N33/567 , C12N5/00 , C12N5/071 , C12N1/21 , C12N1/19 , C12N5/10 , C07K17/00
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, or a detectable marker. These antibodies are of use to detect and/or isolate pancreatic cells or a subset thereof. Methods of treating a pancreatic tumor are also disclosed.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子或可检测标记缀合。 这些抗体可用于检测和/或分离胰腺细胞或其子集。 还公开了治疗胰腺肿瘤的方法。
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公开(公告)号:US08097428B2
公开(公告)日:2012-01-17
申请号:US13010737
申请日:2011-01-20
IPC分类号: G01N33/567
CPC分类号: C07K16/28 , G01N33/56966
摘要: Isolated monoclonal antibodies are disclosed herein that specifically bind a cell surface antigen expressed on the human pancreatic endocrine cells or a subset thereof, and/or a precursor thereof. Isolated monoclonal antibodies are also disclosed herein that specifically bind a cell surface antigen expressed on human pancreatic exocrine cells or human ductal cells. Humanized forms of these antibodies, and functional fragments of these antibodies, are also disclosed. The antibodies can be conjugated to an effector molecule, such as a detectable marker, a therapeutic agent, or a toxin. These antibodies are of use to detect and isolate pancreatic cells or a subset thereof. The antibodies can be used for in vitro or in vivo detection and/or isolation of pancreatic endocrine cells. Methods of treating a pancreatic tumor are also disclosed. In several examples, the isolated monoclonal antibodies bind pancreatic endocrine cells and can be used to detect diabetes or a pancreatic endocrine cell tumor.
摘要翻译: 本文公开了分离的单克隆抗体,其特异性结合在人胰腺内分泌细胞或其子集上表达的细胞表面抗原和/或其前体。 本文还公开了分离的单克隆抗体,其特异性结合在人胰腺外分泌细胞或人导管细胞上表达的细胞表面抗原。 还公开了这些抗体的人源化形式和这些抗体的功能片段。 抗体可以与效应分子缀合,例如可检测标记,治疗剂或毒素。 这些抗体可用于检测和分离胰腺细胞或其子集。 该抗体可用于胰腺内分泌细胞的体外或体内检测和/或分离。 还公开了治疗胰腺肿瘤的方法。 在几个实例中,分离的单克隆抗体结合胰腺内分泌细胞,可用于检测糖尿病或胰腺内分泌细胞肿瘤。
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公开(公告)号:US5538724A
公开(公告)日:1996-07-23
申请号:US812077
申请日:1991-12-19
CPC分类号: C07K16/2884 , A61K38/00
摘要: Methods and compositions are described for modulating trafficking of leukocytes to endothelial cells involving the binding of homing receptors and addressins. Particularly, compositions are provided which can inhibit the interaction between the homing receptor and addressin or provide for directing specific molecules associated with diagnosis or treatment, where the molecules bind to the addressins.
摘要翻译: 描述了用于调节白细胞运送到内皮细胞的方法和组合物,其涉及归巢受体和寻址蛋白的结合。 特别地,提供了可以抑制归巢受体和寻址蛋白之间的相互作用的组合物,或者提供用于引导与诊断或治疗相关联的特定分子,其中分子与地址结合。
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