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公开(公告)号：US08815882B2
公开(公告)日：2014-08-26
申请号：US13292668
申请日：2011-11-09
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译： 式I化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。
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公开(公告)号：US20120157427A1
公开(公告)日：2012-06-21
申请号：US13292668
申请日：2011-11-09
申请人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
发明人： Charles Baker-Glenn , Daniel Jon Burdick , Mark Chambers , Bryan K. Chan , Huifen Chen , Anthony Estrada , Zachary Kevin Sweeney
IPC分类号： A61K31/506 , A61P25/16 , A61K31/5377 , C07D403/12 , C07D413/14
CPC分类号： C07D403/14 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
摘要翻译： 式I化合物或其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗与LRRK2受体（例如帕金森病）相关的疾病的方法。
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公开(公告)号：US20080293664A1
公开(公告)日：2008-11-27
申请号：US12082069
申请日：2008-04-08
IPC分类号： A61K31/5025 , A61P31/18 , C07D471/04 , A61K31/7072 , A61K31/7068 , A61K31/551 , A61K31/513 , A61K31/496 , A61K31/538 , A61K31/708 , A61K31/437 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04
摘要： Compounds of formula I, wherein R1, R2, R3, R4, Ra, X, X1, and Y are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R1，R2，R3，R4，Ra，X，X1和Y如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1的方法 感染和治疗艾滋病和/或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US07166738B2
公开(公告)日：2007-01-23
申请号：US11112591
申请日：2005-04-22
IPC分类号： C07C311/16 , C07C311/17 , C07C311/18
CPC分类号： C07C255/54 , C07C311/24 , C07C311/46 , C07C311/51 , C07C317/40 , C07C317/44 , C07C323/49 , C07C2601/14 , C07D275/02 , C07D295/067
摘要： The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1—R5, R7a, R7b, R7c, R8—R10, X1, X2 m, n, o and p are as defined herein
摘要翻译： 本发明提供用于治疗或预防HIV感染或治疗AIDS或ARC的化合物，其包括给予式I的化合物，其中Ar，R 1，R 5，R R 7，R 7，R 7，R 8，R 8，R 10，X 10， m，n，o和p如本文所定义
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公开(公告)号：US08026362B2
公开(公告)日：2011-09-27
申请号：US12156228
申请日：2008-05-30
IPC分类号： C07D239/02 , C07D233/00
CPC分类号： C07D239/22 , C07D233/72 , C07D233/78 , C07D239/54 , C07D239/545 , C07D239/553
摘要： Compounds of formula I, wherein R1, X1, X2 and A, are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 其中R 1，X 1，X 2和A如本文所定义的式I化合物或其药学上可接受的盐抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染的方法以及治疗AIDS和/ 或ARC。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US20100041648A1
公开(公告)日：2010-02-18
申请号：US12606320
申请日：2009-10-27
IPC分类号： A61K31/535 , A61K31/18 , A61K31/165 , A61K31/425 , A61P31/12 , A61P31/18
CPC分类号： A61K31/277
摘要： The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein with at least one carrier, excipient or diluent.
摘要翻译： 本发明提供用于治疗HIV感染的组合物，包括给予式I化合物，其中Ar，R 1 -R 5，R 11c和X 1如本文所定义与至少一种载体，赋形剂或稀释剂。
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公开(公告)号：US20100004231A1
公开(公告)日：2010-01-07
申请号：US12459595
申请日：2009-07-01
IPC分类号： A61K31/5415 , A61K31/5377 , A61K31/502 , A61K31/497 , C07D417/08 , C07D413/14 , C07D403/10 , C07D403/14 , C07D401/08 , A61P35/00
CPC分类号： C07D403/10 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14
摘要： This application discloses 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.
摘要翻译： 本申请公开了根据通式IV的5-苯基-1H-吡嗪-2-酮衍生物：其中，变量Q，R，Y1，Y2，Y2'，Y3，Y4，n和m如本文所述定义，其抑制 Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了包含式I-V化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：US20090306041A1
公开(公告)日：2009-12-10
申请号：US12322870
申请日：2009-02-05
申请人： Nolan James Dewdney , Joshua Kennedy-Smith , Rama K. Kondru , Bradley E. Loc , Yan Lou , Joel McIntosh , Timothy D. Owens , Michael Soth , Zachary Kevin Sweeney , Joshua Paul Gergely Taygerly
发明人： Nolan James Dewdney , Joshua Kennedy-Smith , Rama K. Kondru , Bradley E. Loc , Yan Lou , Joel McIntosh , Timothy D. Owens , Michael Soth , Zachary Kevin Sweeney , Joshua Paul Gergely Taygerly
IPC分类号： A61K31/4725 , C07D413/14 , C07D401/14 , C07D417/14 , C07D491/107 , A61P29/00 , A61P37/00 , A61K31/496 , A61K31/5377 , A61K31/506 , A61K31/541 , A61P19/02 , A61P35/02
CPC分类号： A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D213/74
摘要： This application discloses 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic Formulae I-III: wherein, variables R, X, Y1, Y2, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formulae I-III and at least one carrier, diluent or excipient.
摘要翻译： 本申请公开了根据通式I-III的5-苯基-1H-吡啶-2-酮和6-苯基-2H-哒嗪-3-酮衍生物：其中，变量R，X，Y 1，Y 2，Y 3，Y 4， n和m定义如本文所述，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I-III化合物和至少一种载体，稀释剂或赋形剂的组合物。
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公开(公告)号：US20080249151A1
公开(公告)日：2008-10-09
申请号：US12079649
申请日：2008-03-28
IPC分类号： A61K31/4196 , C07D249/12 , A61P31/18
CPC分类号： C07D249/12
摘要： Compounds of formula I, wherein R1, R2, R3, R4, R5, X, Y, and Ar are as defined herein or pharmaceutically acceptable salts thereof, inhibit HIV-1 reverse transcriptase and afford a method for prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC. The present invention also relates to compositions containing compounds of formula I useful for the prevention and treatment of HIV-1 infections and the treatment of AIDS and/or ARC.
摘要翻译： 式I的化合物，其中R 1，R 2，R 3，R 4，R 4， 5，X，Y和Ar如本文所定义或其药学上可接受的盐，抑制HIV-1逆转录酶，并提供预防和治疗HIV-1感染和治疗AIDS和/或ARC的方法 。 本发明还涉及含有用于预防和治疗HIV-1感染和治疗AIDS和/或ARC的式I化合物的组合物。
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公开(公告)号：US07348345B2
公开(公告)日：2008-03-25
申请号：US11701881
申请日：2007-02-02
IPC分类号： A61K31/433 , A61K31/4245 , A61K31/4196
CPC分类号： C07D271/113 , C07D249/12 , C07D285/13
摘要： This invention relates to methods of treating an HIV infection with novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts, and methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I.
摘要翻译： 本发明涉及用新型式I杂环化合物治疗HIV感染的方法，其中R 1，R 2，R 4，X 1和X 2， SUP> 2 如本发明概述和药学上可接受的盐所定义，以及用式I化合物抑制或调节人类免疫缺陷病毒（HIV）逆转录酶的方法。
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