公开(公告)号：US08177743B2

公开(公告)日：2012-05-15

申请号：US11107730

申请日：2005-04-18

申请人： Charles D. Lennox

发明人： Charles D. Lennox

IPC分类号： A61M29/00

CPC分类号： A61M25/1027 ,  A61F2/07 ,  A61F2250/0067 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/606 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1088

摘要： Medical devices including a substrate that are expandable from a compressed state to an expanded state; a coating on the substrate, the coating having a drug agent incorporated therein; and a sheath over the coating. The sheath is expandable from a compressed state to an expanded state and has at least one perforation therein. The medical devices are configured such that when the substrate is in a compressed state, the sheath is also in a compressed state and the perforation is substantially closed. When the substrate is in an expanded state, the sheath is also in an expanded state and the perforation is substantially open. The invention also includes a method of using the medical devices for the controlled, localized delivery of a drug agent to a target location within a mammalian body.

公开(公告)号：US07052509B2

公开(公告)日：2006-05-30

申请号：US10706327

申请日：2003-11-12

申请人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

发明人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

IPC分类号： A61F7/00

CPC分类号： A61F7/10 ,  A61F7/0085 ,  A61F2007/0002 ,  A61F2007/0008 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0069 ,  A61F2007/0233

摘要： A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

摘要翻译： 冷却系统包括控制台和诸如头部冷却装置的纸巾冷却装置。 操作者将头部冷却装置应用于患有缺血性损伤风险的患者的头部。 控制台在正面压力下向位于冷却装置和患者头部之间的流体循环空间提供冷却流体。 冷却流体和患者头部之间的直接接触在患者体内提供相对快速的全身低温诱导，从而最小化或预防患者的缺血性损伤。 控制台还使用负量表压力从设置在冷却装置的内缘周围的通道中除去空气。 空气从通道的这种移除将冷却装置的边缘密封到患者的头部，包括与患者头部的头发接触的通道部分，并使冷却流体的泄漏超出冷却装置的边缘 。

公开(公告)号：US07008445B2

公开(公告)日：2006-03-07

申请号：US10424391

申请日：2003-04-25

申请人： Charles D. Lennox

发明人： Charles D. Lennox

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0008 ,  A61F2007/0063 ,  A61F2007/0069 ,  A61F2007/0233

摘要： Disclosed is a system and method for inducing therapeutic levels of hypothermia in a patient in the emergent care setting. The system consists of a small battery operated console and one or more garments. The garments are connected to the console by one or more umbilicals. The console provides cold fluid to the garments under pressure and the garment cools the surface of the body. Fluid returns from the garment back to the console in a closed loop fashion. The console contains an electrical battery and a thermal battery that provides operation of the system for more than one hour. The cooling capacity of the system is sufficient to induce therapeutic levels of hypothermia in approximately 30 to 90 minutes in most patients. Use of the system does not preclude any therapeutic or diagnostic interventions that are commonly performed in the emergent care setting.

公开(公告)号：US06238389B1

公开(公告)日：2001-05-29

申请号：US08940519

申请日：1997-09-30

申请人： Kimberly A. Paddock ,  James E. Mayberry ,  Charles D. Lennox

发明人： Kimberly A. Paddock ,  James E. Mayberry ,  Charles D. Lennox

IPC分类号： A61B1818

CPC分类号： A61B18/1477 ,  A61B18/1815 ,  A61B2018/00083 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/1425 ,  A61N1/403

摘要： A deflectable interstitial ablation device includes an elongated housing, an electrode mounted within the elongated housing, a driver coupled to the electrode, an imaging device integrally mounted within the elongated housing and a deflection system disposed within the elongated housing. The elongated housing has a proximal end, a distal end, and a deflectable segment. The electrode is deployable from a first position within the elongated housing to a second position a predetermined distance beyond the distal end of the elongated housing. The electrode further has a flexible portion capable of deflecting with the deflectable segment of the elongated housing, and can be deployed by the driver with a sufficient force such that penetration of the urethral wall occurs in a single motion. The imaging device further has a flexible portion capable of deflecting with the deflectable segment of the elongated housing. The deflection system has a proximal end in communication with a steering mechanism, for controllably deflecting the deflectable segment of the elongated housing by any angle. The deflection of the deflectable segment allows deflection of the electrode and the imaging device, thus facilitating proper placement of the electrode.

摘要翻译： 可偏转的间质消融装置包括细长壳体，安装在细长壳体内的电极，耦合到电极的驱动器，整体地安装在细长壳体内的成像装置和设置在细长壳体内的偏转系统。 细长的壳体具有近端，远端和可偏转段。 电极可从细长壳体内的第一位置展开至超过细长壳体远端的预定距离的第二位置。 电极还具有能够与细长壳体的可偏转部分偏转的柔性部分，并且可以由驾驶员以足够的力部署，使得尿道壁的穿透以单次运动发生。 成像装置还具有能够与细长壳体的可偏转部分偏转的柔性部分。 偏转系统具有与转向机构连通的近端，用于可控地将细长壳体的可偏转部分偏转任何角度。 可偏转段的偏转允许电极和成像装置偏转，从而有助于电极的正确放置。

公开(公告)号：US5782848A

公开(公告)日：1998-07-21

申请号：US707060

申请日：1996-09-03

申请人： Charles D. Lennox

发明人： Charles D. Lennox

IPC分类号： A61B17/22 ,  A61B1/00 ,  A61B1/12 ,  A61B17/32 ,  A61B18/00 ,  A61B18/14 ,  A61B19/00

CPC分类号： A61B1/12 ,  A61B17/32002 ,  A61B18/24 ,  A61B2017/320012 ,  A61B2018/0097 ,  A61B2090/373

摘要： The invention relates to quickly and efficiently removing coagulated tissue within a body lumen without affecting the normal, healthy, untreated tissue, to minimize post-operative complications such as bleeding or edema formation. For example, in an aspect, the invention features a surgical resecting brush assembly. The assembly includes an elongated catheter sized and constructed for delivery through an extended body lumen to a site that is occluded with body matter that has been effected by heat treatment and a brush formation near the distal end of the catheter. The brush formation includes a bristle structure of sufficient stiffness to resect and remove the effected bodily matter without substantially damaging adjacent healthy tissue when the brush formation is actuated relative to the occluded site.

摘要翻译： 本发明涉及快速且有效地去除体腔内的凝固组织，而不影响正常的，健康的，未经处理的组织，以尽量减少术后并发症，例如出血或水肿形成。 例如，在一方面，本发明的特征在于一种手术切除刷组件。 组件包括细长的导管，其尺寸和构造用于通过延伸的体腔输送到已经通过热处理实现的身体物质的位置和在导管的远端附近的刷子形成。 刷子形成包括具有足够刚度的刷毛结构，以在相对于闭塞部位致动刷子形成时切除并移除受影响的身体物质而基本上不损坏邻近的健康组织。

公开(公告)号：US5368591A

公开(公告)日：1994-11-29

申请号：US981006

申请日：1992-11-23

申请人： Charles D. Lennox ,  Richard A. Noddin ,  Ronald Sahatjian

发明人： Charles D. Lennox ,  Richard A. Noddin ,  Ronald Sahatjian

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/04 ,  A61B18/08 ,  A61F7/12

CPC分类号： A61B18/082 ,  A61B18/08 ,  A61B17/22 ,  A61B2017/00084 ,  A61B2017/00088 ,  A61B2017/00132 ,  A61B2017/00274 ,  A61B2017/22062 ,  A61B2018/0022 ,  A61B2018/00547 ,  A61B2018/00559 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/044

摘要： Device and method for heating tissue, the device having a catheter shaft for insertion into a patient's body, a chamber formed by a collapsible balloon mounted on the catheter shaft and filled with an electrically conductive fluid, two or more electrical contacts enclosed within the chamber, a power supply for applying an electrical potential to the contacts, and a two or more conductors for connecting each of the contacts to the power supply. The fluid is heated on the basis of I.sup.2 R losses by a radio frequency electric current flowing between the electrodes, and the fluid in turn heats the surrounding tissue by heat transfer through the wall of the chamber. According to the method, the apparatus is inserted into the patient's body, the chamber is filled with an electrically conductive fluid, and an electrical potential is applied to the contacts. The apparatus functions as a temperature source. A thermister sensor in the balloon or in contact with tissue responds to the heating effect to control the application of the current. Advantageously, by periodic sensing of temperature, and application of controlled rf power, a preset constant temperature is maintained at the selected sensing point, either at the internal body site or the liquid within the balloon. In this way carefully controlled therapy can be conducted at constant temperature.

摘要翻译： 用于加热组织的装置和方法，所述装置具有用于插入患者体内的导管轴，由可安装在导管轴上并填充有导电流体的可折叠气囊形成的腔室，封闭在腔室内的两个或更多个电触点， 用于向触点施加电势的电源，以及用于将每个触点连接到电源的两个或更多个导体。 基于I2R损耗，通过在电极之间流动的射频电流来加热流体，并且流体又通过腔室壁的热传递来加热周围组织。 根据该方法，将该装置插入到患者体内，对该腔室填充有导电性流体，并向触点施加电位。 该装置用作温度源。 气囊中的热敏传感器或与组织接触的热敏电阻传感器响应加热效应以控制电流的施加。 有利地，通过周期性地检测温度和施加受控射频功率，在所选择的感测点处，在内部身体部位或球囊内的液体中保持预设的恒定温度。 这样可以在恒温下进行精心控制的治疗。

公开(公告)号：US08529613B2

公开(公告)日：2013-09-10

申请号：US11870441

申请日：2007-10-11

申请人： Jeffrey Radziunas ,  Charles D. Lennox

发明人： Jeffrey Radziunas ,  Charles D. Lennox

IPC分类号： A61F7/00

CPC分类号： A61F7/10 ,  A61F2007/0008 ,  A61F2007/0056

摘要： A thermal cap that can fit a variety of head sizes is disclosed. The cap can include a shell having a fluid inlet and outlet, a sealing mechanism and removable sizing layers disposed within the shell. Depending upon the size of a patient's head, sizing layers can either be added to or removed from the outer shell to maintain a fluid circulation space between the head and the rigid shell and allow substantially even distribution of a thermal fluid about the scalp of the patient during operation. The shell is preferably rigid and an elastomeric member can seal the periphery of the cap to the patient's head to prevent leakage. Other types and aspects of thermal cap systems are also disclosed.

摘要翻译： 公开了可以适应各种头部尺寸的热盖。 盖可以包括具有流体入口和出口的壳体，密封机构和设置在壳体内的可移除的筛分层。 取决于患者头部的尺寸，上浆层可以被添加到外壳中或从外壳移除，以保持头部和刚性壳体之间的流体循环空间，并允许围绕患者头皮的热流体基本均匀地分布 在运行期间。 壳体优选是刚性的，并且弹性体构件可以将盖的周边密封到患者的头部以防止泄漏。 还公开了热盖系统的其它类型和方面。

公开(公告)号：US07621945B2

公开(公告)日：2009-11-24

申请号：US11284114

申请日：2005-11-21

申请人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

发明人： Charles D. Lennox ,  Steven M. Johnson ,  Susan Beinor ,  Maria Benson ,  Don Paul Nogueira ,  John W. Carroll ,  Helen Maslocka

IPC分类号： A61F7/00

CPC分类号： A61F7/10 ,  A61F7/0085 ,  A61F2007/0002 ,  A61F2007/0008 ,  A61F2007/0056 ,  A61F2007/0063 ,  A61F2007/0069 ,  A61F2007/0233

摘要： A cooling system includes a console and a tissue cooling device such as a head-cooling device. An operator applies the head-cooling device to the head of a patient at risk for ischemic injury. The console provides a cooling fluid to a fluid circulation space located between the cooling device and the patient's head under a positive gage pressure. Direct contact between the cooling fluid and the patient's head provides a relatively rapid induction of systemic hypothermia in the patient, thereby minimizing or preventing ischemic injury in the patient. The console also removes air from a channel disposed about an inner rim of the cooling device, using a negative gage pressure. Such removal of the air from the channel seals the rim of the cooling device to the head of the patient, including portions of the channel in contact with hair of the patient's head, and minimizes leaking of the cooling fluid beyond the rim of the cooling device.

摘要翻译： 冷却系统包括控制台和诸如头部冷却装置的纸巾冷却装置。 操作者将头部冷却装置应用于患有缺血性损伤风险的患者的头部。 控制台在正面压力下向位于冷却装置和患者头部之间的流体循环空间提供冷却流体。 冷却流体和患者头部之间的直接接触在患者体内提供相对快速的全身低温诱导，从而最小化或预防患者的缺血性损伤。 控制台还使用负量表压力从设置在冷却装置的内缘周围的通道中除去空气。 空气从通道的这种移除将冷却装置的边缘密封到患者的头部，包括与患者头部的头发接触的通道部分，并使冷却流体的泄漏超出冷却装置的边缘 。

公开(公告)号：US07547291B2

公开(公告)日：2009-06-16

申请号：US11018836

申请日：2004-12-21

申请人： Charles D. Lennox ,  Ronald B. Lamport ,  Andrew H. Levine ,  Douglas E. Godshall ,  Aaron Perlmutter ,  Steven Nordstrom

发明人： Charles D. Lennox ,  Ronald B. Lamport ,  Andrew H. Levine ,  Douglas E. Godshall ,  Aaron Perlmutter ,  Steven Nordstrom

IPC分类号： A61M5/00 ,  A61F2/04

CPC分类号： A61F2/0022 ,  A61B5/205 ,  A61F2/0018 ,  A61F2/0027

摘要： A urethral prosthesis provides relief of urinary retention and has first and second tubular elements with an interposed bridge segment. A valve can be disposed in the second tubular element to control the flow of urine therethrough.

公开(公告)号：US07156867B2

公开(公告)日：2007-01-02

申请号：US10330638

申请日：2002-12-27

申请人： Charles D. Lennox

发明人： Charles D. Lennox

IPC分类号： A61F7/00

CPC分类号： A61F7/12 ,  A61B2017/00084 ,  A61F2007/0008 ,  A61F2007/0056 ,  A61F2007/126

摘要： Disclosed is an apparatus and method for uniform selective cerebral hypothermia. The apparatus includes a brain-cooling probe, a head-cooling cap, a body-heating device and a control console. The brain-cooling probe cools the cerebrospinal fluid within one or more brain ventricles. The brain-cooling probe withdraws a small amount of cerebrospinal fluid from a ventricle into a cooling chamber located ex-vivo in close proximity to the head. After the cerebrospinal fluid is cooled it is then reintroduced back into the ventricle. This process is repeated in a cyclical or continuous manner. The head-cooling cap cools the cranium and therefore cools surface of the brain. The combination of ventricle cooling and cranium cooling provides for whole brain cooling while minimizing temperature gradients within the brain. The body-heating device replaces heat removed from the body by the brain-cooling probe and the head-cooling cap and provides for a temperature difference between the brain and the body where the brain is maintained a temperature lower than the temperature of the body.

摘要翻译： 公开了用于均匀选择性脑低温的装置和方法。 该装置包括脑冷却探针，头冷却帽，身体加热装置和控制台。 脑冷却探针冷却一个或多个脑室内的脑脊液。 脑冷却探针将少量脑脊液从心室抽入位于离体位置靠近头部的冷却室中。 脑脊液冷却后，再重新引入脑室。 以循环或连续方式重复该过程。 头冷却帽冷却头盖，从而冷却脑部表面。 脑室冷却和颅脑冷却的组合提供了全脑冷却，同时使脑内的温度梯度最小化。 身体加热装置通过脑冷却探针和头部冷却帽代替从体内除去的热量，并且提供脑和身体之间的温度差，其中脑保持低于身体温度的温度。