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1.发明申请公开(公告)号：US20110130616A1
公开(公告)日：2011-06-02
申请号：US12505111
申请日：2009-07-17
CPC分类号： A61N2/12 , A61K9/1641 , A61K9/1676 , A61K9/5094
摘要： Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field. A method for treating cancer comprises administering and magnetically guiding a therapeutic construct comprising paclitaxel.
摘要翻译： 磁响应治疗载体包括纳米颗粒，其包括包含磁铁矿并且具有1至50纳米的平均粒度范围的单畴纳米颗粒，单畴纳米颗粒的簇，簇的平均簇尺寸为5至1000纳米，混合物 的两个。 单畴纳米颗粒用二氧化硅涂层包封。 硅烷偶联剂与二氧化硅涂层结合，并具有能够与治疗剂选择性结合的特异性侧链官能团。 优选地，特定侧基官能团与治疗剂之间的键是共价键。 磁性反应性纳米颗粒治疗构建体的运动，在靶位点（如癌性肿瘤）上具有浓度和外渗/内吞作用，使用可控磁场发生器，其适于在三维中移动治疗构建体，并且使用重复变化的磁 领域。 用于治疗癌症的方法包括施用和磁性引导包含紫杉醇的治疗构建体。
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2.发明授权Single step milling and surface coating process for preparing stable nanodispersions 有权单步研磨和表面涂层工艺，用于制备稳定的纳米分散体公开(公告)号：US08357426B2
公开(公告)日：2013-01-22
申请号：US12267400
申请日：2008-11-07
CPC分类号： B05D3/12 , A61K8/11 , A61K8/29 , A61K2800/413 , A61Q17/04 , B01J2/006 , B82Y30/00 , C01G9/02 , C01G23/047 , C01P2004/51 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C01P2006/12 , C09C1/3623 , C09C1/3661 , C09C1/3676 , C09C1/3692
摘要： A single step milling and surface coating process allows for production of a stable dispersion of surface coated nanoparticles in an efficient manner. The process comprises providing feed particles, providing a coating agent, and generating the stable dispersion of surface coated nanoparticles by milling the feed particles in an aqueous medium containing the coating agent such that the coating agent bonds to surfaces of the feed particles as the feed particles are milled to an average particle size of less than about 100 nm.
摘要翻译： 单步研磨和表面涂覆工艺允许以有效的方式生产表面包被的纳米颗粒的稳定分散体。 该方法包括提供进料颗粒，提供涂层剂，以及通过在含有涂层剂的水性介质中研磨进料颗粒而产生表面包被的纳米颗粒的稳定分散体，使得涂覆剂与进料颗粒的表面作为进料颗粒 被研磨成小于约100nm的平均粒度。
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3.发明授权Magnetically responsive nanoparticle therapeutic constructs and methods of making and using 有权磁响应纳米颗粒治疗结构及其制备和使用方法公开(公告)号：US08651113B2
公开(公告)日：2014-02-18
申请号：US12505111
申请日：2009-07-17
IPC分类号： A61B19/00
CPC分类号： A61N2/12 , A61K9/1641 , A61K9/1676 , A61K9/5094
摘要： Magnetically responsive therapeutic carriers comprise nanoparticles including single-domain nanoparticles comprising magnetite and having an average particle size ranging between 1 and 50 nanometers, clusters of the single-domain nanoparticles, the clusters having an average cluster size ranging between 5 and 1000 nanometers, and mixtures of the two. The single-domain nanoparticles are encapsulated with a silica coating. A silane coupling agent is bonded to the silica coating and has a specific pendant functional group capable of selectively binding with the therapeutic. Preferably, the bond between the specific pendant functional group and the therapeutic is a covalent bond. The movement of magnetically responsive nanoparticle therapeutic constructs, with concentration and extravasation/endocytosis at a target site, such as cancerous tumors, uses a controllable magnetic field generator adapted to move the therapeutic constructs in three dimensions, and is enhanced using a repetitively-varying magnetic field. A method for treating cancer comprises administering and magnetically guiding a therapeutic construct comprising paclitaxel.
摘要翻译： 磁响应治疗载体包括纳米颗粒，其包括包含磁铁矿并且具有1至50纳米的平均粒度范围的单畴纳米颗粒，单畴纳米颗粒的簇，簇的平均簇尺寸为5至1000纳米，混合物 的两个。 单畴纳米颗粒用二氧化硅涂层包封。 硅烷偶联剂与二氧化硅涂层结合，并具有能够与治疗剂选择性结合的特异性侧链官能团。 优选地，特定侧基官能团与治疗剂之间的键是共价键。 磁性反应性纳米颗粒治疗构建体的运动，在靶位点（如癌性肿瘤）上具有浓度和外渗/内吞作用，使用可控磁场发生器，其适于在三维中移动治疗构建体，并且使用重复变化的磁 领域。 用于治疗癌症的方法包括施用和磁性引导包含紫杉醇的治疗构建体。
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4.发明申请SINGLE STEP MILLING AND SURFACE COATING PROCESS FOR PREPARING STABLE NANODISPERSIONS 有权单步铣削和表面涂装工艺，用于制备稳定的纳米尺寸公开(公告)号：US20090180976A1
公开(公告)日：2009-07-16
申请号：US12267400
申请日：2008-11-07
CPC分类号： B05D3/12 , A61K8/11 , A61K8/29 , A61K2800/413 , A61Q17/04 , B01J2/006 , B82Y30/00 , C01G9/02 , C01G23/047 , C01P2004/51 , C01P2004/52 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C01P2006/12 , C09C1/3623 , C09C1/3661 , C09C1/3676 , C09C1/3692
摘要： A single step milling and surface coating process allows for production of a stable dispersion of surface coated nanoparticles in an efficient manner. The process comprises providing feed particles, providing a coating agent, and generating the stable dispersion of surface coated nanoparticles by milling the feed particles in an aqueous medium containing the coating agent such that the coating agent bonds to surfaces of the feed particles as the feed particles are milled to an average particle size of less than about 100 nm.
摘要翻译： 单步研磨和表面涂覆工艺允许以有效的方式生产表面包被的纳米颗粒的稳定分散体。 该方法包括提供进料颗粒，提供涂层剂，以及通过在含有涂层剂的水性介质中研磨进料颗粒而产生表面包被的纳米颗粒的稳定分散体，使得涂覆剂与进料颗粒的表面作为进料颗粒 被研磨成小于约100nm的平均粒度。
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公开(公告)号：US4973492A
公开(公告)日：1990-11-27
申请号：US510003
申请日：1990-04-13
申请人： Donald D. Gibson
发明人： Donald D. Gibson
CPC分类号： A23L13/67 , A23L13/428
摘要： Barbecue meat patties of a pre-determined weight are formed by an automated process which includes the steps of providing a barbecue sauce including at least 5% of a binder, such as molasses and ketchup, mixing meat with the sauce to form barbecue meat while chilling the meat and sauce to a temperature of 28.degree. F. to 32.degree. F., forming the chilled meat and sauce into patties under a pressure of 70 to 80 psi, and gradually freezing the patties to storage temperature.
摘要翻译： 通过自动化方法形成预定重量的烧烤肉馅饼，其包括提供包含至少5％的粘合剂如糖蜜和番茄酱的烧烤酱的步骤，将肉与酱混合以形成烧烤肉，同时冷却 将肉和酱调到28°F至32°F的温度下，在70至80psi的压力下将冷冻的肉和酱油形成馅饼，并逐渐将馅饼冻结至储存温度。
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公开(公告)号：US4492071A
公开(公告)日：1985-01-08
申请号：US535093
申请日：1983-09-23
申请人： Donald D. Gibson
发明人： Donald D. Gibson
CPC分类号： B65G49/062 , B65B23/20
摘要： This specification discloses a method for preparing a plurality of large blocks of glass for shipment on a transportable device (10). The method includes providing an "A" frame carrier (18) on the transportable device. A plurality of layers of shrinkable film (32) and (34) are provided which lie over and on both sides of the "A" frame carrier. A block of glass is loaded on each side of the "A" frame carrier and wrapped in the layer (34) of shrinkable film in a manner that each of the first glass blocks is substantially enclosed in the shrinkable film. The shrinkable film is shrunk about the enclosed block of glass thereby to form a sealed pouch pack (36) about the first loaded block of glass. At least a second block of glass is loaded on each side of the "A" frame carrier in association with the previously loaded blocks of glass. Each of the newly loaded blocks of glass is wrapped in the layer (32) of the shrinkable film in a manner such that each of the newly loaded glass blocks is substantially enclosed in the shrinkable film. The shrinkable film is then shrunk about the substantially enclosed glass blocks thereby to form a sealed pouch pack (40--40) about each of the newly loaded glass blocks.
摘要翻译： 本说明书公开了一种用于制备用于在可运输装置（10）上装运的多个大块玻璃的方法。 该方法包括在可移动设备上提供“A”帧载波（18）。 提供了多层可收缩薄膜（32）和（34），它们位于“A”框架载体的两侧。 将一块玻璃装载在“A”框架架的每侧，并以可收缩薄膜的每个第一玻璃块基本封闭的方式包裹在可收缩薄膜层（34）中。 收缩膜围绕封闭的玻璃块收缩，从而形成围绕第一个装载的玻璃块的密封的袋子包装（36）。 至少第二个玻璃块与先前装载的玻璃块相关联地装载在“A”框架载体的每一侧上。 每个新加载的玻璃块以可接收的膜的大致封闭的方式包裹在可收缩膜的层（32）中。 然后，可收缩膜围绕基本上封闭的玻璃块收缩，从而围绕每个新装载的玻璃块形成密封的袋包装（40-40）。
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