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    Oral immunization with transgenic plants
    1.
    发明授权
    Oral immunization with transgenic plants 失效
    用转基因植物进行口服免疫

    公开(公告)号：US06395964B1

    公开(公告)日：2002-05-28

    申请号：US08817906

    申请日：1997-08-04

    申请人： Charles J. Arntzen ,  Hugh S. Mason ,  Haq A. Tariq ,  John D. Clements

    发明人： Charles J. Arntzen ,  Hugh S. Mason ,  Haq A. Tariq ,  John D. Clements

    IPC分类号： C12N504

    CPC分类号： C07K14/28 ,  A61K39/04 ,  A61K39/08 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/542 ,  A61K2039/55544 ,  C07K14/245 ,  C12N15/8258

    摘要： The oral antigens and adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed, and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogen and adjuvants when the transgenic plant material expressing the antigens is fed to animals.

    摘要翻译： 本发明的口服抗原和佐剂在转基因植物中产生，然后通过消耗转基因植物施用。 构建天然和合成编码免疫原性表达的DNA序列，其在饲喂可食用植物，植物组织或衍生植物材料时能够在动物中引起免疫应答，植物转化用于在植物细胞中稳定或瞬时表达 。 本发明提供了用于通过转基因植物免疫动物的第一已知功能方法，其中当将表达抗原的转基因植物材料供给动物时，植物表达作为免疫原和佐剂的细菌抗原。

    DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS
    2.
    发明申请
    DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 审中-公开
    DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗

    公开(公告)号：US20140141515A1

    公开(公告)日：2014-05-22

    申请号：US13944589

    申请日：2013-07-17

    申请人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    发明人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    IPC分类号： C12N15/82

    CPC分类号： C12N15/8257 ,  C12N15/8203 ,  C12N15/8258

    摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

    摘要翻译： 植物病毒载体在快速生产蛋白质方面具有巨大的潜力，但不是简单的。这里描述了用于高产率和快速生产低聚蛋白复合物（包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb））的基于双恶病毒的系统 。 特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。 还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。 该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

    Oral immunization with transgenic plants
    3.
    发明授权
    Oral immunization with transgenic plants 有权
    用转基因植物进行口服免疫

    公开(公告)号：US06194560B1

    公开(公告)日：2001-02-27

    申请号：US09191852

    申请日：1998-11-12

    申请人： Charles J. Arntzen ,  Hugh S. Mason ,  Tariq A. Haq

    发明人： Charles J. Arntzen ,  Hugh S. Mason ,  Tariq A. Haq

    IPC分类号： A61K39108

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C07K14/245 ,  C12N15/8258 ,  C12N2770/16022 ,  Y02A50/472

    摘要： The oral vaccines and oral vaccine adjuvants of the present invention are produced in transgenic plants and then administered through the consumption of the transgenic plant. DNA sequences both natural and synthetic encoding for the expression of immunogenic agents which are capable of causing an immune response in animals when fed in edible plants, plant tissues, or derived plant materials are constructed and plants transformed for stable or transient expression in plant cells. The present invention provides the first known functional method for immunizing animals via transgenic plants, where the plants express bacterial antigens that act as both immunogens and adjuvants when the transgenic plant material expressing the antigens is fed to animals.

    摘要翻译： 本发明的口服疫苗和口服疫苗佐剂在转基因植物中生产，然后通过消耗转基因植物来施用。 构建天然和合成编码免疫原性试剂表达的DNA序列，其在饲喂可食用植物，植物组织或衍生植物材料时能够在动物中引起免疫应答，植物转化以在植物细胞中稳定或短暂表达。 本发明提供了用于通过转基因植物免疫动物的第一已知功能方法，其中当将表达抗原的转基因植物材料供给动物时，植物表达作为免疫原和佐剂的细菌抗原。

    Expression of recombinant human acetylcholinesterase in transgenic plants
    6.
    发明授权
    Expression of recombinant human acetylcholinesterase in transgenic plants 有权

    公开(公告)号：US06770799B2

    公开(公告)日：2004-08-03

    申请号：US09810861

    申请日：2001-03-16

    申请人： Tsafrir S. Mor ,  Hermona Soreq ,  Charles J. Arntzen ,  Hugh S. Mason

    发明人： Tsafrir S. Mor ,  Hermona Soreq ,  Charles J. Arntzen ,  Hugh S. Mason

    IPC分类号： A01H100

    CPC分类号： C12N15/8242 ,  C12N9/18 ,  C12N15/8257

    摘要： Briefly stated, the invention includes a method of making a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, and regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant. Another embodiment of the invention includes a method of making a physiologically active human acetylcholinesterase, comprising the steps of introducing into at least one plant cell a polynucleotide that encodes a human acetylcholinesterase, regenerating from the plant cell a transgenic plant that is capable of expressing a physiologically active human acetylcholinesterase in at least one tissue type of the transgenic plant, and isolating or purifying from the transgenic plant or a part thereof a physiologically active human acetylcholinesterase.

    DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants
    8.
    发明授权
    DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants 有权
    用于在植物中高水平快速生产疫苗和单克隆抗体治疗剂的DNA复制子系统

    公开(公告)号：US08513397B2

    公开(公告)日：2013-08-20

    申请号：US13060414

    申请日：2009-08-27

    申请人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    发明人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    IPC分类号： C12N15/34 ,  C12N15/117 ,  C12N15/13 ,  C12N15/36 ,  C12N15/82 ,  C12N5/10

    CPC分类号： C12N15/8257 ,  C12N15/8203 ,  C12N15/8258

    摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

    摘要翻译： 植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。 这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。 特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。 还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。 该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。

    DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS
    9.
    发明申请
    DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS 有权
    DNA复制系统，用于高产快速生产疫苗和单克隆抗体在植物中的治疗

    公开(公告)号：US20110262966A1

    公开(公告)日：2011-10-27

    申请号：US13060414

    申请日：2009-08-27

    申请人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    发明人： Hugh S. Mason ,  Zhong Huang ,  Qiang Chen ,  Charles J. Arntzen ,  Shuo Yuan ,  Brooke Hjelm

    IPC分类号： C12P1/00 ,  C12P21/00 ,  C12P19/34 ,  C12N15/63

    CPC分类号： C12N15/8257 ,  C12N15/8203 ,  C12N15/8258

    摘要： Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes.

    摘要翻译： 植物病毒载体在快速生产蛋白质方面具有很大的潜力，但并不简单。 这里描述了用于高产率和快速生产低聚蛋白复合物的双基因病毒的系统，包括病毒样颗粒（VLP）疫苗和单克隆抗体（mAb）。 特别地，描述了在烟草属烟草叶中含有两个用于瞬时表达的非竞争性复制子的单一载体。 还描述了将这些亚基蛋白正确组装到功能性寡聚结构（VLP或全尺寸mAb）中。 该系统通过消除对非竞争病毒的需求，推进植物瞬时表达技术，从而增强了该技术生产多亚基蛋白复合物的实际商业应用。