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公开(公告)号:US06562627B1
公开(公告)日:2003-05-13
申请号:US09471854
申请日:1999-12-23
申请人: Charles Pidgeon , Jianming Yin , Nadege Rooke , Ling Han Morgan
发明人: Charles Pidgeon , Jianming Yin , Nadege Rooke , Ling Han Morgan
IPC分类号: G01N3002
CPC分类号: G01N30/96 , G01N30/02 , G01N30/34 , G01N30/72 , G01N30/7233 , G01N30/8637 , G01N30/89 , G01N2030/527 , Y10T436/16
摘要: Methods are provided for determining a dissociation constant for each one of at least a portion of a set of compounds. The methods include contacting a solution of the set of compounds with a membrane mimetic surface exhibiting a non-specific compound-dependent affinity for at least the portion of the compounds. A parameter dependent on the non-specific affinity of the surface for each one of at least the portion of the set of compounds in the test solution is measured and used to calculate the dissociation constant.
摘要翻译: 提供了用于确定一组化合物的至少一部分中的每一个的解离常数的方法。 所述方法包括使该组化合物的溶液与至少部分化合物表现出非特异性化合物依赖性亲和力的膜模拟表面接触。 测量取决于测试溶液中至少部分化合物的至少一部分中每一个表面的非特异性亲和力的参数,并用于计算解离常数。
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公开(公告)号:US06641783B1
公开(公告)日:2003-11-04
申请号:US09499904
申请日:2000-02-08
申请人: Charles Pidgeon , Jianming Yin , Nadege Rooke , Sonyuan Lin , Jeffrey Giles
发明人: Charles Pidgeon , Jianming Yin , Nadege Rooke , Sonyuan Lin , Jeffrey Giles
IPC分类号: G01N3002
CPC分类号: G01N30/466 , G01N30/06 , G01N30/16 , G01N30/20 , G01N30/468 , G01N30/7266 , G01N30/82 , G01N30/84 , G01N2030/204 , G01N2030/527 , G01N2030/625 , G01N2030/628 , Y10T436/11 , G01N30/10 , G01N2030/328
摘要: This invention relates to a high efficiency chromatographic system. More specifically, the present invention relates to a chromatographic system for determining the physicochemical properties of one or more compounds using at least two chromatographic units in eluent flow communication with one eluent analyzer via an intermediate eluent switch. The present chromatographic system allows determination of physicochemical properties through the use of multiple chromatographic units in communication with one eluent analyzer via an eluent switch.
摘要翻译: 本发明涉及一种高效色谱系统。 更具体地说,本发明涉及一种用一种或多种化合物的物理化学性质来确定一种或多种化合物的色谱系统,所述化合物使用至少两个色谱单元,其通过中间洗脱液开关与一个洗脱液分析器进行洗脱液流动连通。 本色谱系统可以通过使用多个色谱单元通过洗脱液开关与一个洗脱液分析仪进行通讯来确定物理化学性质。
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