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    High throughput method for measurement of physicochemical values
    2.
    发明授权
    High throughput method for measurement of physicochemical values 失效
    用于测量物理化学值的高通量方法

    公开(公告)号：US06562627B1

    公开(公告)日：2003-05-13

    申请号：US09471854

    申请日：1999-12-23

    申请人： Charles Pidgeon ,  Jianming Yin ,  Nadege Rooke ,  Ling Han Morgan

    发明人： Charles Pidgeon ,  Jianming Yin ,  Nadege Rooke ,  Ling Han Morgan

    IPC分类号： G01N3002

    CPC分类号： G01N30/96 ,  G01N30/02 ,  G01N30/34 ,  G01N30/72 ,  G01N30/7233 ,  G01N30/8637 ,  G01N30/89 ,  G01N2030/527 ,  Y10T436/16

    摘要： Methods are provided for determining a dissociation constant for each one of at least a portion of a set of compounds. The methods include contacting a solution of the set of compounds with a membrane mimetic surface exhibiting a non-specific compound-dependent affinity for at least the portion of the compounds. A parameter dependent on the non-specific affinity of the surface for each one of at least the portion of the set of compounds in the test solution is measured and used to calculate the dissociation constant.

    摘要翻译： 提供了用于确定一组化合物的至少一部分中的每一个的解离常数的方法。 所述方法包括使该组化合物的溶液与至少部分化合物表现出非特异性化合物依赖性亲和力的膜模拟表面接触。 测量取决于测试溶液中至少部分化合物的至少一部分中每一个表面的非特异性亲和力的参数，并用于计算解离常数。

    Drug discovery using multiple membrane mimetic affinities
    3.
    发明授权
    Drug discovery using multiple membrane mimetic affinities 失效
    药物发现使用多个膜模拟亲和力

    公开(公告)号：US06829540B1

    公开(公告)日：2004-12-07

    申请号：US09486168

    申请日：2000-02-22

    申请人： Charles Pidgeon ,  Hanlan Liu ,  Kimberly Hauer ,  Jianming Yin ,  Song J. Cai

    发明人： Charles Pidgeon ,  Hanlan Liu ,  Kimberly Hauer ,  Jianming Yin ,  Song J. Cai

    IPC分类号： G01N3348

    CPC分类号： G01N33/5076 ,  G01N30/02 ,  G01N30/89 ,  G06F19/704 ,  B01D15/3852

    摘要： The measurement of multiple membrane affinities of test compounds, methods and compositions useful for acquiring data characteristic of such affinities, and a method and system for using such data alone or in combination with other molecular descriptors for the prediction of biological activity are described. The numerical values characteristic of biologically relevant interaction of test compounds with membrane mimetic surfaces are compared with corresponding values of one or more control compounds having a known biological activity. Probable biological activity of a test compound is identified with those control compounds whose multiple membrane interaction values most closely correlate to those of the test compound.

    摘要翻译： 描述了测试化合物的多个膜亲和力的测量，用于获得这种亲和力特征的方法和组合物，以及单独使用这些数据或与其他分子描述符组合用于预测生物活性的方法和系统。 将测试化合物与膜模拟表面的生物相关相互作用特征的数值与具有已知生物活性的一种或多种对照化合物的相应值进行比较。 用多个膜相互作用值与测试化合物的最密切相关的那些对照化合物鉴定测试化合物的可能的生物学活性。

    Quinoline derivative and use thereof
    4.
    发明授权
    Quinoline derivative and use thereof 有权

    公开(公告)号：US10689361B2

    公开(公告)日：2020-06-23

    申请号：US16266000

    申请日：2019-02-02

    申请人： Jianming Yin

    发明人： Jianming Yin

    IPC分类号： C07D401/12 ,  A61P35/00 ,  A61K31/4709 ,  A61K31/47 ,  A61P9/00 ,  C07D215/46 ,  C07D215/233 ,  C07D215/48

    摘要： Provided are a novel quinoline derivative, or a pharmaceutically acceptable salt, a hydrate, or a metabolite formed by metabolism in any form thereof, and use thereof in preparing a medicine for preventing and/or treating indications associated with angiogenesis. The quinoline derivative is an ideal and high-efficiency VEGFR inhibitor, and is able to be used to treat or prevent tumour growth and other metastasis growth diseases associated with angiogenesis.