公开(公告)号：US20140018725A1

公开(公告)日：2014-01-16

申请号：US13980723

申请日：2012-01-20

申请人： Charles Potter ,  John Watson

发明人： Charles Potter ,  John Watson

IPC分类号： A61M37/00

CPC分类号： A61M37/0069 ,  A61B17/3468 ,  A61M31/007 ,  A61M2005/005

摘要： The present invention relates to novel drug delivery technology in the form of solid dose injection devices and methods which utilise a blade that is pushed into the skin to a predetermined depth before the before a solid drug formulation is pushed into the cut made by the blade. Thus the present invention also relates to delivering a therapeutic compound to a human or animal in the form of a solid dose injection comprising: providing an injection device comprising a casing; an actuation mechanism capable of ei generating a force, a blade, a solid drug formulation; and a means for pushing said solid drug formulation; wherein the blade is inser ted to a predetermined depth in the skin and, following insertion of the blade, the device is actuated such that the actuation mechanism capable of generating a force acts on the means for pushing to push the solid drug formulation out of the casing and into the human or animal body.

摘要翻译： 本发明涉及以固体剂量注射装置和方法形式的新型药物递送技术，其利用在固体药物制剂被推入由刀片制成的切口之前被推入皮肤中的刀片达预定深度。 因此，本发明还涉及以固体剂量注射的形式将治疗性化合物递送至人或动物，其包括：提供包括壳体的注射装置; 能够产生力的致动机构，叶片，固体药物制剂; 以及推动所述固体药物制剂的方法; 其中所述刀片插入到所述皮肤中的预定深度，并且在所述刀片插入之后，所述装置被致动，使得能够产生力的所述致动机构作用于推动所述固体药物制剂的装置 套管并进入人体或动物体内。

公开(公告)号：US08596959B2

公开(公告)日：2013-12-03

申请号：US12576261

申请日：2009-10-09

申请人： Eric Durocher ,  John Watson

发明人： Eric Durocher ,  John Watson

IPC分类号： F01D11/00

CPC分类号： F16L59/143 ,  F01D9/065 ,  F01M11/02

摘要： A gas turbine engine has an oil tube for delivering oil through a high temperature zone of the engine to an engine component for cooling and lubrication. An insulation tube surrounds the oil tube and extends in a substantial length of the oil tube. The opposed ends of the insulation tube are integrally and sealingly connected to respective end portions of the oil tube to form a dead air annulus between the oil tube and the insulation tube.

摘要翻译： 燃气涡轮发动机具有用于将油通过发动机的高温区域输送到用于冷却和润滑的发动机部件的油管。 绝缘管围绕油管并在油管的相当长的长度上延伸。 绝缘管的相对端一体地密封地连接到油管的相应端部，以在油管和绝缘管之间形成死空气环。

公开(公告)号：US08575101B2

公开(公告)日：2013-11-05

申请号：US13167488

申请日：2011-06-23

申请人： Jason Schense ,  John Watson ,  Isabelle Arrighi

发明人： Jason Schense ,  John Watson ,  Isabelle Arrighi

IPC分类号： A61K38/29 ,  A61K9/00 ,  C07K14/635

CPC分类号： A61K38/29 ,  A61L27/225 ,  A61L27/427 ,  A61L27/46 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/43 ,  A61L2430/02 ,  C07K14/635 ,  C07K2319/00

摘要： Supplemented matrices comprising a PTH releasably incorporated therein, optionally containing a granular material, which are used to heal bone fractures, particularly bone fractures with a risk of becoming delayed unions or non-unions, are described herein. The PTH is incorporated either through covalent linkage to the matrix or through non-covalent interaction with the matrix and/or the granules. These supplemented matrices decrease the time of healing compared to autograft and or trigger healing of bone fractures which otherwise would not heal. The matrices are biocompatible, preferably biodegradable, and can be formed in vitro or in vivo, at the time of implantation. The PTH may be a part of a fusion peptide. PTH can be incorporated into the matrices with full retention of its bioactivity. PTH can be releasably incorporated in the matrix.

摘要翻译： 本文描述了包含可释放地并入其中的PTH的补充基质，任选地含有颗粒材料，其用于治疗骨折，特别是具有变为延迟联合或非联合的风险的骨折。 通过共价连接到基质中或通过与基质和/或颗粒的非共价相互作用掺入PTH。 与自体移植相比，这些补充的基质减少愈合时间和/或触发骨折的愈合，否则不会愈合。 基质是生物相容的，优选可生物降解的，并且可以在植入时在体外或体内形成。 PTH可能是融合肽的一部分。 PTH可以并入到具有完全保留其生物活性的基质中。 PTH可以可释放地并入基质中。

公开(公告)号：US08250339B2

公开(公告)日：2012-08-21

申请号：US11962979

申请日：2007-12-21

申请人： Paul L. Master ,  Stephen J. Smith ,  John Watson

发明人： Paul L. Master ,  Stephen J. Smith ,  John Watson

IPC分类号： G06F13/00

CPC分类号： G06F15/80 ,  G06F7/57 ,  G06F9/44505 ,  G06F15/7867 ,  Y02D10/12 ,  Y02D10/13

摘要： The present invention concerns configuration of a new category of integrated circuitry for adaptive computing. The various embodiments provide an executable information module for an adaptive computing engine (ACE) integrated circuit and may include configuration information, operand data, and may also include routing and power control information. The ACE IC comprises a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure the plurality of heterogeneous computational elements for a plurality of different functional modes.

摘要翻译： 本发明涉及用于自适应计算的新类别的集成电路的配置。 各种实施例提供用于自适应计算引擎（ACE）集成电路的可执行信息模块，并且可以包括配置信息，操作数数据，并且还可以包括路由和功率控制信息。 ACE IC包括耦合到互连网络的多个异构计算元件。 多个异构计算元件包括具有固定和不同架构的对应的计算元件，例如用于不同功能的固定架构，例如存储器，加法，乘法，复数乘法，减法，配置，重配置，控制，输入，输出和现场可编程性。 响应于配置信息，互连网络用于为多个不同的功能模式配置多个异构计算元件。

公开(公告)号：US08061006B2

公开(公告)日：2011-11-22

申请号：US10484751

申请日：2002-07-25

申请人： Mark Anthony Fernance Kendall ,  Edward R. Smith ,  John Watson ,  Graham Ford

发明人： Mark Anthony Fernance Kendall ,  Edward R. Smith ,  John Watson ,  Graham Ford

IPC分类号： B23P11/02 ,  A61M5/30

CPC分类号： A61M5/3015 ,  A61M5/24 ,  A61M5/2459 ,  Y10T29/49826 ,  Y10T29/4987 ,  Y10T29/49876 ,  Y10T29/49885 ,  Y10T29/49893 ,  Y10T29/49904 ,  Y10T29/49947

摘要： A kit of parts for use in the manufacture of a particle cassette for a needleless syringe device. The kit may include a first cassette part having a first rupturable membrane sealed thereto and a second cassette part having a second rupturable membrane sealed thereto. The first and second cassette parts may be arranged to be attachable together so as to create a chamber for the confinement of particles between the first and second membranes. The first and second cassette parts may be substantially annular and the first cassette part defines a receptacle for receiving particles. The second cassette part may be attachable concentrically around or inside the first cassette part.

摘要翻译： 用于制造无针注射器装置的颗粒盒的一组零件。 套件可以包括具有密封在其上的第一可破裂膜的第一盒部件和具有密封到其上的第二可破裂膜的第二盒部件。 第一和第二盒部件可以被布置成可附接在一起，以便产生用于在第一和第二膜之间限制颗粒的室。 第一和第二盒部件可以是大致环形的，并且第一盒部件限定用于接收颗粒的容器。 第二盒部件可以同心地附接在第一盒部件的内部或内部。

公开(公告)号：US20110053554A1

公开(公告)日：2011-03-03

申请号：US11908245

申请日：2006-02-23

申请人： Gavin Wong ,  John Watson

发明人： Gavin Wong ,  John Watson

IPC分类号： H04W4/10 ,  H04W4/24

CPC分类号： H04L65/4061 ,  H04L65/1016 ,  H04M15/00 ,  H04M15/56 ,  H04M15/57 ,  H04M2215/202 ,  H04M2215/2026 ,  H04M2215/2093 ,  H04M2215/32 ,  H04W4/10 ,  H04W4/24 ,  H04W76/45 ,  H04W80/10 ,  H04W84/08

摘要： A telecommunications system is described which allows a push-to-talk: over cellular (PoC) communication session to be established between PoC Clients comprised in respective mobile terminals (1A, 1A′, 1B). The PoC Clients form a group of devices between which a PoC communication session is established. A single controlling PoC function (22B) controls the admission of new members to the PoC communication session and the removal of members from the PoC communication session. Each PoC Client communicates with the PoC controlling function (22B) via a respective PoC participating function (20A, 20A′,20B). In accordance with an advantageous feature of the embodiment described, the controlling PoC function (22B) issues a Talk Burst Granted message having a modified form to a PoC Client (via its associated PoC participating function) when that client is given permission to transmit a talk burst. The modified Talk Burst Granted message includes an indication of the number of active members in the PoC communication session. This information is extracted by the relevant PoC participating function and enables that PoC participating function to determine the number of PoC Clients to which the talk burst originating from its PoC Client will be transmitted. This enables the PoC participating function to provide an indication to its PoC Client of the number of PoC Clients to which its talk bursts will be transmitted and/or to cause a charge to be rendered to the user of its PoC Client in accordance with the number of recipients.

摘要翻译： 描述了允许在包括在各个移动终端（1A，1A'，1B）中的PoC客户端之间建立一键通（PoE）通信会话的通信系统。 PoC客户端形成一组PoC通信会话建立在该设备之间。 单一控制PoC功能（22B）控制新成员进入PoC通信会话并从PoC通信会话中删除成员。 每个PoC客户端经由相应的PoC参与功能（20A，20A'，20B）与PoC控制功能（22B）进行通信。 根据所描述的实施例的有利特征，当该客户端被允许发送话音时，控制PoC功能（22B）向PoC客户端（经由其相关联的PoC参与功能）发出具有修改形式的通话突发授权消息 爆裂。 修改的通话突发消息包括PoC通信会话中活动成员的数量的指示。 该信息由相关的PoC参与功能提取，并使得PoC参与功能能够确定将从其PoC客户端发起的通话短信发送到的PoC客户端的数量。 这使得PoC参与功能能够向其PoC客户端提供其通话突发将被发送到的PoC客户端的数量和/或使得根据号码向PoC客户端的用户呈现费用的指示 的收件人。

公开(公告)号：US20090172137A1

公开(公告)日：2009-07-02

申请号：US12399671

申请日：2009-03-06

申请人： Paul L. Master ,  Stephen J. Smith ,  John Watson

发明人： Paul L. Master ,  Stephen J. Smith ,  John Watson

IPC分类号： G06F15/177

CPC分类号： G06F15/7867 ,  G06F13/40 ,  Y02D10/12 ,  Y02D10/13 ,  Y02D10/14 ,  Y02D10/151

摘要： The present invention concerns configuration of a new category of integrated circuitry for adaptive or reconfigurable computing. The preferred adaptive computing engine (ACE) IC includes a plurality of heterogeneous computational elements coupled to an interconnection network. The plurality of heterogeneous computational elements include corresponding computational elements having fixed and differing architectures, such as fixed architectures for different functions such as memory, addition, multiplication, complex multiplication, subtraction, configuration, reconfiguration, control, input, output, and field programmability. In response to configuration information, the interconnection network is operative to configure and reconfigure the plurality of heterogeneous computational elements for a plurality of different functional modes, including linear algorithmic operations, non-linear algorithmic operations, finite state machine operations, controller operations, memory operations, and bit-level manipulations. The preferred system embodiment includes an ACE integrated circuit coupled with the configuration information needed to provide an operating mode. Preferred methodologies include various means to generate and provide configuration information for various operating modes.

摘要翻译： 本发明涉及用于自适应或可重新配置计算的新类别的集成电路的配置。 优选的自适应计算引擎（ACE）IC包括耦合到互连网络的多个异构计算元件。 多个异构计算元件包括具有固定和不同架构的对应的计算元件，例如用于不同功能的固定架构，例如存储器，加法，乘法，复数乘法，减法，配置，重配置，控制，输入，输出和现场可编程性。 响应于配置信息，互连网络可操作以配置和重新配置用于多种不同功能模式的多个异构计算元件，包括线性算法运算，非线性算法运算，有限状态机操作，控制器操作，存储器操作 和位级操作。 优选的系统实施例包括耦合到提供操作模式所需的配置信息的ACE集成电路。 优选的方法包括生成和提供各种操作模式的配置信息的各种手段。

公开(公告)号：US20070118762A1

公开(公告)日：2007-05-24

申请号：US11598325

申请日：2006-11-12

申请人： Paul Master ,  John Watson

发明人： Paul Master ,  John Watson

IPC分类号： H04L9/00 ,  G06F12/14 ,  H04K1/00 ,  H04L9/32 ,  G06F11/30

CPC分类号： G06F21/73 ,  G06F21/10 ,  G06F21/72 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/605 ,  H04L2209/80

摘要： The present invention includes an apparatus, method and system for generating a configuration of an adaptive circuit which is inseparable from selected content. Either the adaptive circuit or encrypted, selected content has a unique identifier. In one of the preferred method and system embodiments in which the adaptive circuit has the unique identifier, a request for the selected content is received, along with the unique identifier, such as by a network server. The selected content is then encrypted, based upon the unique identifier, to form encrypted content. Configuration information for the adaptive circuit, corresponding to the unique identifier and the encrypted content, is generated to form corresponding configuration information. A service provider, such as through a network server, transfers the encrypted content and the corresponding configuration information to the adaptive circuit having the unique identifier, which may then be configured for use of the selected content. As a consequence, the present invention creates adaptive hardware configurations which are uniquely coupled to the selected content.

摘要翻译： 本发明包括用于生成与选定内容不可分离的自适应电路的配置的装置，方法和系统。 自适应电路或加密的所选择的内容都具有唯一的标识符。 在其中自适应电路具有唯一标识符的优选方法和系统实施例之一中，接收对所选内容的请求以及诸如网络服务器的唯一标识符。 然后，基于唯一标识符对所选择的内容进行加密，以形成加密的内容。 产生对应于唯一标识符和加密内容的自适应电路的配置信息，以形成对应的配置信息。 诸如通过网络服务器的服务提供商将加密的内容和相应的配置信息传送到具有唯一标识符的自适应电路，然后可以将其配置为使用所选择的内容。 因此，本发明创建独特地耦合到所选内容的自适应硬件配置。

公开(公告)号：US20060080532A1

公开(公告)日：2006-04-13

申请号：US11282460

申请日：2005-11-19

申请人： Paul Master ,  John Watson

发明人： Paul Master ,  John Watson

IPC分类号： H04L9/00

CPC分类号： G06F21/73 ,  G06F21/10 ,  G06F21/72 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/605 ,  H04L2209/80

摘要： The present invention includes an apparatus, method and system for generating a configuration of an adaptive circuit which is inseparable from selected content. Either the adaptive circuit or encrypted, selected content has a unique identifier. In one of the preferred method and system embodiments in which the adaptive circuit has the unique identifier, a request for the selected content is received, along with the unique identifier, such as by a network server. The selected content is then encrypted, based upon the unique identifier, to form encrypted content. Configuration information for the adaptive circuit, corresponding to the unique identifier and the encrypted content, is generated to form corresponding configuration information. A service provider, such as through a network server, transfers the encrypted content and the corresponding configuration information to the adaptive circuit having the unique identifier, which may then be configured for use of the selected content. As a consequence, the present invention creates adaptive hardware configurations which are uniquely coupled to the selected content.

公开(公告)号：US20060015733A1

公开(公告)日：2006-01-19

申请号：US11148255

申请日：2005-06-09

申请人： John O'Malley ,  Scott Hansen ,  Helen Beckel ,  Samuel Kilmer ,  John Watson ,  Clifford Ludwick

发明人： John O'Malley ,  Scott Hansen ,  Helen Beckel ,  Samuel Kilmer ,  John Watson ,  Clifford Ludwick

IPC分类号： H04L9/00

CPC分类号： G07D7/004 ,  G07F7/08 ,  G07F7/12

摘要： A method, system and product for the material reduction of counterfeit and identity/maker fraud as it relates to payment vehicles and other authentication-requiring documents. The authentication system allows an institution to apply a code comprising relevant elements of an end-user to an authentication-requiring document. The authentication system allows institutions to validate the authentication-requiring documents at the point of presentment. The authentication system is stand alone and self-authenticating, allowing institutions to include the method, system and product anywhere in the institutions' document verification or manufacturing process.

摘要翻译： 涉及付款车辆和其他认证要求的文件的方式，系统和产品，用于减少伪造和身份/制造商欺诈的物品。 认证系统允许机构将包括最终用户的相关元素的代码应用于需要认证的文档。 认证系统允许机构在呈现点验证需要认证的文档。 认证体系是独立自我认证的，允许机构在机构的文件验证或制造过程中的任何地方包括方法，系统和产品。