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1.发明申请公开(公告)号：US20100268078A1
公开(公告)日：2010-10-21
申请号：US12823598
申请日：2010-06-25
IPC分类号： A61B6/00
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information.
摘要翻译： 肿瘤学监测系统包括：（a）配置成驻留在患者的目标肿瘤治疗部位附近的第一组多个辐射传感器，所述传感器被配置为提供与肿瘤治疗部位相关联的辐射数据; 和（b）与所述多个传感器通信的第一便携式接收器。 接收器被配置为在多个不同时间从传感器获得辐射数据。 接收器与本地和/或远程计算机进行通信，跟踪辐射数据中的变化以提供动态肿瘤位点信息。
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2.发明授权Methods, systems, and associated implantable devices for detecting radiation in patients undergoing treatment for cancer 有权用于检测接受癌症治疗的患者的辐射的方法，系统和相关的可植入装置公开(公告)号：US07787937B2
公开(公告)日：2010-08-31
申请号：US11185284
申请日：2005-07-20
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
摘要翻译： 用于评估递送给受试者的外部束放射治疗的方法和系统包括：（a）将至少一个无线可植入传感器放置在目标位置的第一受试者中; （b）向第一受试者施用第一剂量的放射治疗; （c）从所述至少一个无线可植入传感器获得辐射数据; 以及（d）基于在暴露于第一次施用的辐射剂量之后和/或之后从至少一个无线传感器获得的辐射数据来计算由目标位置处的第一受试者接收的辐射剂量量，以确定和/或验证 输送到目标位置的剂量的辐射。
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公开(公告)号：US07778692B2
公开(公告)日：2010-08-17
申请号：US11381233
申请日：2006-05-02
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
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公开(公告)号：US07769431B2
公开(公告)日：2010-08-03
申请号：US11381223
申请日：2006-05-02
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into tile first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
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5.发明申请IMPLANTABLE DEVICES FOR DYNAMIC MONITORING OF PHYSIOLOGICAL AND BIOLOGICAL PROPERTIES OF TUMORS 有权用于动态监测肿瘤生理和生物学特性的可植入装置公开(公告)号：US20100261983A1
公开(公告)日：2010-10-14
申请号：US12823521
申请日：2010-06-25
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译： 配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。
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公开(公告)号：US07010340B2
公开(公告)日：2006-03-07
申请号：US10078310
申请日：2002-02-18
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
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7.发明授权Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权用于动态监测肿瘤的生理和生物学特性的方法，系统和相关的可植入装置公开(公告)号：US07756568B2
公开(公告)日：2010-07-13
申请号：US11148608
申请日：2005-06-09
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Biocompatible sensors configured for implantation include a first body in communication with a plurality of remote sensor bodies to detect physiological parameters in vivo.
摘要翻译： 配置用于植入的生物相容性传感器包括与多个远程传感器体通信的第一体，以检测体内生理参数。
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8.发明授权Methods, systems, and associated implantable devices for radiation dose verification for therapies used to treat tumors 有权用于治疗肿瘤治疗的放射剂量验证的方法，系统和相关的可植入装置公开(公告)号：US06963771B2
公开(公告)日：2005-11-08
申请号：US10655317
申请日：2003-09-04
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods and systems for evaluating external beam radiation therapy delivered to a subject include: (a) placing at least one wireless implantable sensor in a first subject at a target location; (b) administering a first dose of radiation therapy into the first subject; (c) obtaining radiation data from the at least one wireless implantable sensor; and (d) calculating a radiation dose amount received by the first subject at the target location based on the radiation data obtained from the at least one wireless sensor during and/or after exposure to the first administered dose of radiation to determine and/or verify a dose amount of radiation delivered to the target location.
摘要翻译： 用于评估递送给受试者的外部束放射治疗的方法和系统包括：（a）将至少一个无线可植入传感器放置在目标位置的第一受试者中; （b）向第一受试者施用第一剂量的放射治疗; （c）从所述至少一个无线可植入传感器获得辐射数据; 以及（d）基于在暴露于第一次施用的辐射剂量之后和/或之后从至少一个无线传感器获得的辐射数据来计算由目标位置处的第一受试者接收的辐射剂量量，以确定和/或验证 输送到目标位置的剂量的辐射。
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9.发明授权Methods, systems, and associated implantable devices for dynamic monitoring of physiological and biological properties of tumors 有权用于动态监测肿瘤的生理和生物学特性的方法，系统和相关的可植入装置公开(公告)号：US06963770B2
公开(公告)日：2005-11-08
申请号：US10422120
申请日：2003-04-24
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Methods of monitoring and evaluating the status of a tumor undergoing treatment includes monitoring in vivo at least one physiological parameter associated with a tumor in a subject undergoing treatment, transmitting data from an in situ located sensor to a receiver external of the subject, analyzing the transmitted data, repeating the monitoring and transmitting steps at sequential points in time and evaluating a treatment strategy. The method provides dynamic tracking of the monitored parameters over time. The method can also include identifying in a substantially real time manner when conditions are favorable for treatment and when conditions are unfavorable for treatment and can verify or quantify how much of a known drug dose or radiation dose was actually received at the tumor. The method can include remote transmission from a non-clinical site to allow oversight of the tumor's condition even during non-active treatment periods (in between active treatments). The disclosure also includes monitoring systems with in situ in vivo biocompatible sensors and telemetry based operations and related computer program products.
摘要翻译： 监测和评估正在进行治疗的肿瘤状态的方法包括在体内监测经受治疗的受试者中与肿瘤相关的至少一个生理参数，将数据从原位定位的传感器传输到对象外部的接受体，分析所传送的 数据，在连续的时间点重复监测和传送步骤，并评估治疗策略。 该方法提供了随时间监视的参数的动态跟踪。 该方法还可以包括当条件有利于治疗时以及当条件不利于治疗时以基本上实时的方式进行鉴定，并且可以验证或量化在肿瘤中实际接收了多少已知药物剂量或辐射剂量。 该方法可以包括从非临床部位的远程传输，以允许即使在非活动治疗期间（在主动治疗之间）也可以监视肿瘤的状况。 本公开还包括具有原位体内生物相容性传感器和基于遥测的操作和相关计算机程序产品的监测系统。
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公开(公告)号：US09662049B2
公开(公告)日：2017-05-30
申请号：US12823598
申请日：2010-06-25
申请人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
发明人： Charles W. Scarantino , H. Troy Nagle , Lester C. Hall , Jeffrey Mueller , Bahram Ghaffarzadeh Kermani
IPC分类号： A61B6/00 , A61B5/145 , A61B5/00 , A61B5/1473 , A61B5/1486 , A61B5/1495 , G06F19/00 , A61N5/10
CPC分类号： A61B5/14539 , A61B5/0031 , A61B5/1473 , A61B5/1486 , A61B5/14865 , A61B5/1495 , A61B5/417 , A61B6/507 , A61B2562/028 , A61B2562/085 , A61N5/1048 , A61N5/1071 , G06F19/00 , G06F19/3481 , Y10S128/903 , Y10S128/904 , Y10S128/92
摘要： Oncology monitoring systems include: (a) a first plurality of radiation sensors configured to reside proximate a target tumor treatment site of a patient, the sensors being configured to provide radiation data associated with the tumor treatment site; and (b) a first portable receiver in communication with the plurality of sensors. The receiver is configured to obtain radiation data from the sensors at a plurality of different times. The receiver is in communication with a local and/or remote computer that tracks variation in the radiation data to provide dynamic tumor site information.
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