公开(公告)号：US20210180104A1

公开(公告)日：2021-06-17

申请号：US16752573

申请日：2020-01-24

申请人： Chengyuan LIANG ,  Liang XIN ,  Guaiping QIAO ,  Jingyi LI ,  Kangxiong WU ,  Han LI ,  Bin TIAN

发明人： Chengyuan LIANG ,  Liang XIN ,  Guaiping QIAO ,  Jingyi LI ,  Kangxiong WU ,  Han LI ,  Bin TIAN

IPC分类号： C12Q1/04 ,  C07K14/78

摘要： A method of preparing a hydroxytyrosol sturgeon skin gelatin film with antioxidant activity and Salmonella detection ability includes: (1) mixing a neutral red indicator solution and distilled water at room temperature to obtain a mixture solution, and adding 1 mol/L NaHCO3 solution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrol gelatin solution, and heating the hydroxytyrol gelatin solution at 40-70° C.; (4) ultrasonicating the hydroxytyrol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.

公开(公告)号：US20220235008A1

公开(公告)日：2022-07-28

申请号：US17157916

申请日：2021-01-25

申请人： Wenbo YAO ,  Guaiping QIAO ,  Nan HUI ,  Juan LI ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Han LI ,  Gennian MAO ,  Bin TIAN ,  Dan YANG ,  Chengyuan LIANG

发明人： Wenbo YAO ,  Guaiping QIAO ,  Nan HUI ,  Juan LI ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Han LI ,  Gennian MAO ,  Bin TIAN ,  Dan YANG ,  Chengyuan LIANG

IPC分类号： C07D215/233 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220194918A1

公开(公告)日：2022-06-23

申请号：US17128103

申请日：2020-12-19

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Nan HUI ,  Guaiping QIAO ,  Han LI ,  Yanjun LI ,  Liang QI ,  Wenbo YAO ,  Gennian MAO ,  Chengyuan LIANG

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Nan HUI ,  Guaiping QIAO ,  Han LI ,  Yanjun LI ,  Liang QI ,  Wenbo YAO ,  Gennian MAO ,  Chengyuan LIANG

IPC分类号： C07D339/04 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

公开(公告)号：US20220348540A1

公开(公告)日：2022-11-03

申请号：US17239582

申请日：2021-04-24

申请人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Ruina BIAN ,  Jie ZHANG ,  Qianqian ZHAO ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： C07C323/52 ,  A61P31/04 ,  C07C319/28

摘要： A compound with anti-drug resistant bacteria activity having the formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220354826A1

公开(公告)日：2022-11-10

申请号：US17239583

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Dan YANG ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG ,  Liang QI ,  Gennian MAO

IPC分类号： A61K31/4164 ,  A61P31/04

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220348539A1

公开(公告)日：2022-11-03

申请号：US17239575

申请日：2021-04-24

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Jie ZHANG ,  Yuqing ZHAO ,  Dan YANG ,  Han LI ,  Bin TIAN ,  Yongbo WANG ,  Chengyuan LIANG

IPC分类号： C07C323/52 ,  C07C319/20

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20220259138A1

公开(公告)日：2022-08-18

申请号：US17175582

申请日：2021-02-12

申请人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Dan YANG ,  Liang QI ,  Bin TIAN ,  Jian ZHA ,  Wenbo YAO ,  Gennian MAO ,  Han LI ,  Chunyang SHI ,  Yongbo WANG ,  Jingwen XU

发明人： Qianqian ZHAO ,  Liang XIN ,  Jingyi LI ,  Ruina BIAN ,  Dan YANG ,  Liang QI ,  Bin TIAN ,  Jian ZHA ,  Wenbo YAO ,  Gennian MAO ,  Han LI ,  Chunyang SHI ,  Yongbo WANG ,  Jingwen XU

IPC分类号： C07C69/88 ,  C07C67/14 ,  C07C67/08

摘要： A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

公开(公告)号：US20230172889A1

公开(公告)日：2023-06-08

申请号：US17695741

申请日：2022-03-15

申请人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

发明人： Chengyuan LIANG ,  Liang XIN ,  Juan XIA ,  Yuqing ZHAO ,  Jie ZHANG ,  Lei TIAN ,  Jingyi LI ,  Shaojun ZHANG ,  Qianqian ZHAO

IPC分类号： A61K31/216 ,  A61P31/04

CPC分类号： A61K31/216 ,  A61P31/04

摘要： A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I)




R1, R2, R3, R4 and R5 are independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

公开(公告)号：US20220160805A1

公开(公告)日：2022-05-26

申请号：US17173622

申请日：2021-02-11

申请人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Chunyang SHI ,  Xiaolin XIE ,  Dezhu ZHANG ,  Ruina BIAN ,  Xingke JU ,  Chengyuan LIANG ,  Yanjun LI ,  Qiao ZENG

发明人： Dan YANG ,  Jingyi LI ,  Liang XIN ,  Chunyang SHI ,  Xiaolin XIE ,  Dezhu ZHANG ,  Ruina BIAN ,  Xingke JU ,  Chengyuan LIANG ,  Yanjun LI ,  Qiao ZENG

IPC分类号： A61K36/63 ,  A61K31/7034 ,  A61K31/7048 ,  A61K47/44 ,  A61P31/04

摘要： A Syringa microphylla seed extract includes the following components by weight based on a total weight of the Syringa microphylla seed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing the Syringa microphylla seed extract is disclosed. A composition for treating antibiotic-resistant infections that includes the Syringa microphylla seed extract is also disclosed.

公开(公告)号：US20230128907A1

公开(公告)日：2023-04-27

申请号：US17942941

申请日：2022-09-12

申请人： Jia WAN ,  Chunchun KONG ,  Shunjun DING ,  Jingyi LI ,  Lei TIAN

发明人： Jia WAN ,  Chunchun KONG ,  Shunjun DING ,  Jingyi LI ,  Lei TIAN

IPC分类号： A61K36/896 ,  A61K31/7048 ,  A61P31/04

摘要： A method of preparing a Paris polyphylla saponin extract includes: (1) adding Paris polyphylla saponin in 60-90% ethanol to obtain a mixture, heating the mixture under reflux for 2-4 hours; (2) concentrating the mixture to ¼ volume, centrifuging the mixture to obtain a supernatant A and a precipitate A, adding the precipitate A to 60-80% ethanol to obtain a supernatant B and a precipitate B, washing the precipitate B with water and petroleum ether and drying; and (3) combining the supernatant A and the supernatant B, mixing with a macroporous adsorption resin, loading to a chromatography column, eluting the chromatography column with water and 80-90% ethanol, collecting an ethanol eluent, concentrating the ethanol eluent to obtain an eluent extract, and combining the eluent extract and the precipitate B and drying to obtain the Paris polyphylla saponin extract.