公开(公告)号：US08097703B2

公开(公告)日：2012-01-17

申请号：US11917750

申请日：2006-06-20

申请人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

发明人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

IPC分类号： C07K16/00 ,  C07K17/00 ,  C12P21/08 ,  C07K14/00

CPC分类号： C07K16/2803 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77 ,  Y02A50/412

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

公开(公告)号：US20090142349A1

公开(公告)日：2009-06-04

申请号：US11917750

申请日：2006-06-20

申请人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

发明人： Chetana Rao-Naik ,  David John King ,  Jie Liu ,  Haichun Huang ,  David B. Passmore ,  Alasdair Fraser Bell ,  Josephine M. Cardarelli ,  Chin Pan ,  To Uyen Thi Do ,  Sharline Chen ,  Dawn M. Tanamachi

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  C12P21/08 ,  A61P35/00 ,  A61P19/02

CPC分类号： C07K16/2803 ,  A61K47/6817 ,  A61K47/6825 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/732 ,  C07K2317/77 ,  Y02A50/412

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD19 with high affinity. Nucleic acid molecules encoding such CD19 antibodies, expression vectors, host cells and methods for expressing the CD19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD19 antibodies are also provided. Methods for detecting CD19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合CD19的人单克隆抗体。 还提供了编码这种CD19抗体的核酸分子，表达载体，宿主细胞和用于表达CD19抗体的方法。 还提供了免疫偶联物，双特异性分子和包含CD19抗体的药物组合物。 公开了用于检测CD19的方法，以及用于治疗各种B细胞恶性肿瘤（包括非霍奇金淋巴瘤）的方法。

公开(公告)号：US08481683B2

公开(公告)日：2013-07-09

申请号：US12517183

申请日：2007-11-30

申请人： David John King ,  Alison Witte ,  Heidi N. LeBlanc ,  Richard Theolis ,  Asna Masood ,  Mark Yamanaka ,  Kyra D. Zens ,  Sarah R. Reed ,  Tim Sproul ,  Chetana Rao-Naik ,  David Passmore ,  Dawn M. Tanamachi ,  Kristopher Toy

发明人： David John King ,  Alison Witte ,  Heidi N. LeBlanc ,  Richard Theolis ,  Asna Masood ,  Mark Yamanaka ,  Kyra D. Zens ,  Sarah R. Reed ,  Tim Sproul ,  Chetana Rao-Naik ,  David Passmore ,  Dawn M. Tanamachi ,  Kristopher Toy

IPC分类号： C12P21/08 ,  C07K16/00 ,  A61K39/395 ,  A61K39/40 ,  C07K1/00

CPC分类号： C07K16/2803 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6829 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  C07K2317/92

摘要： The present disclosure provides isolated monoclonal antibodies that specifically bind to CD22 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CD22, as well as methods for treating various cancers and inflammatory and autoimmune disorders using an anti-CD22 antibody of this disclosure.

摘要翻译： 本公开提供了以高亲和力特别是人单克隆抗体特异性结合CD22的分离的单克隆抗体。 还提供编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法。 还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含本公开的抗体的药物组合物。 本公开还提供了用于检测CD22的方法，以及使用本公开的抗CD22抗体治疗各种癌症和炎性和自身免疫性疾病的方法。

公开(公告)号：US20110020329A1

公开(公告)日：2011-01-27

申请号：US12745337

申请日：2008-11-26

申请人： David J. King ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

发明人： David J. King ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N5/09 ,  A61P35/00

CPC分类号： A61K47/6869 ,  A61K47/6809

摘要： Anti-RG-1 antibodies, antibody fragments, or antibody mimetics conjugated to partner molecules, such as drugs, radioisotopes, and cytotoxins, wherein the partner molecule exerts its effect regardless of whether the RG-1 bound conjugate is internalized within a targeted cell, are useful for treating cancers.

摘要翻译： 抗RG-1抗体，抗体片段或偶联于配偶体分子（例如药物，放射性同位素和细胞毒素）的抗体模拟物，其中配偶体分子发挥其作用，而不管RG-1结合的缀合物是否内化在靶细胞内， 可用于治疗癌症。

公开(公告)号：US20090162372A1

公开(公告)日：2009-06-25

申请号：US12271623

申请日：2008-11-14

申请人： David J. KING ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

发明人： David J. KING ,  Jonathan A. Terrett ,  Sanjeev Gangwar ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Chin Pan

IPC分类号： A61K39/395 ,  C07K16/00 ,  A61P35/00

CPC分类号： C07K16/18 ,  A61K47/6803 ,  A61K47/6843 ,  A61K47/6851 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/92

摘要： The present invention provides anti-ED-B antibodies, antibody fragments, and antibody mimetics and such antibodies conjugated to a partner molecule, wherein the antibody or the antibody-partner molecule conjugate provides a therapeutic effect regardless of whether the ED-B-antibody or ED-B-conjugate complex is internalized within a targeted cell.

摘要翻译： 本发明提供抗ED-B抗体，抗体片段和抗体模拟物以及与配偶体分子缀合的抗体，其中抗体或抗体 - 配偶体分子缀合物提供治疗效果，而不管ED-B-抗体或 ED-B-缀合物复合体内化在靶细胞内。

公开(公告)号：US20120093826A1

公开(公告)日：2012-04-19

申请号：US13254752

申请日：2010-03-05

申请人： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

发明人： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

IPC分类号： A61K39/395 ,  C12N15/13 ,  C12N15/63 ,  A61P35/02 ,  C12P21/08 ,  C12N5/16 ,  A61P35/00 ,  C07K16/28 ,  C12N5/10

CPC分类号： C07K16/3007 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

摘要翻译： 本公开内容提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。

公开(公告)号：US08420084B2

公开(公告)日：2013-04-16

申请号：US13254752

申请日：2010-03-05

申请人： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

发明人： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/46

CPC分类号： C07K16/3007 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

摘要翻译： 本公开内容提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。

公开(公告)号：US20100104509A1

公开(公告)日：2010-04-29

申请号：US12519149

申请日：2007-12-13

申请人： David John King ,  Chetana Rao-Naik ,  Chin Pan ,  Josephine Cardarelli ,  Diann Blanset

发明人： David John King ,  Chetana Rao-Naik ,  Chin Pan ,  Josephine Cardarelli ,  Diann Blanset

IPC分类号： A61K51/00 ,  C07K16/00 ,  A61K39/395

CPC分类号： C07K16/2803 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

摘要： Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body

摘要翻译： 公开了以高亲和力特异性结合CD19的人单克隆抗体。抗体能够内化成表达CD19的细胞或能够介导抗原依赖性细胞毒性编码抗体，表达载体，宿主细胞的核酸分子和表达 还提供了抗体还提供了抗体 - 配偶体分子缀合物，双特异性分子和包含抗体的药物组合物。还提供了用于检测CD19的方法，以及用于治疗癌症的方法，例如B细胞恶性肿瘤，例如非霍奇金淋巴瘤 ，慢性淋巴细胞性白血病，滤泡性淋巴瘤，B系弥漫性大细胞淋巴瘤，以及使用抗CD19抗体的多种骨髓瘤

公开(公告)号：US20110085970A1

公开(公告)日：2011-04-14

申请号：US12745677

申请日：2008-11-26

申请人： Jonathan A. Terrett ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Bingliang Chen ,  David J. King

发明人： Jonathan A. Terrett ,  Josephine M. Cardarelli ,  Chetana Rao-Naik ,  Bingliang Chen ,  David J. King

IPC分类号： A61K51/10 ,  C07K16/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K47/6851 ,  A61K47/6817 ,  A61K47/6825

摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to B7H4 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided, immunoconjugates, including antibody-drug conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for treating cancer.

摘要翻译： 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合B7H4的人单克隆抗体。 还提供了编码本公开的抗体的核酸分子，表达载体，宿主细胞和用于表达本公开的抗体的方法，还提供免疫缀合物，包括抗体 - 药物偶联物，双特异性分子和包含本公开的抗体的药物组合物 。 本公开还提供了治疗癌症的方法。

公开(公告)号：US20120027782A1

公开(公告)日：2012-02-02

申请号：US12745503

申请日：2008-11-26

申请人： Jonathan Alexander Terrett ,  Chin Pan ,  Chetana Rao-Naik

发明人： Jonathan Alexander Terrett ,  Chin Pan ,  Chetana Rao-Naik

IPC分类号： A61K39/44 ,  A61P35/00 ,  C12N15/63 ,  C12N5/10 ,  C07K17/02 ,  C12N15/13

CPC分类号： A61K47/6851 ,  A61K47/6817 ,  A61K47/6825

摘要： The present disclosure relates to antibody-partner molecule conjugates directed to PTK7. Also described are methods for treating or preventing a disease characterized by growth of tumor cells expressing PTK7 using the antibody-partner molecule conjugates.

摘要翻译： 本公开涉及针对PTK7的抗体 - 配偶体分子缀合物。 还描述了使用抗体 - 配偶体分子缀合物治疗或预防以表达PTK7的肿瘤细胞生长为特征的疾病的方法。