公开(公告)号：US08522602B2

公开(公告)日：2013-09-03

申请号：US13091435

申请日：2011-04-21

申请人： Chi-Yen Shen ,  Ke-Nung Huang ,  Shen-Li Fu ,  Jian-Jhong Chen ,  Yu-Fong Huang

发明人： Chi-Yen Shen ,  Ke-Nung Huang ,  Shen-Li Fu ,  Jian-Jhong Chen ,  Yu-Fong Huang

IPC分类号： G01N11/00 ,  G01N1/00

CPC分类号： G01N33/54306 ,  G01N33/4915 ,  G01N35/1095

摘要： A system is provided for detecting a liquid sample, and includes: a flow cell assembly formed with a sample receiving space therein, and inlet and outlet channels extending to the sample receiving space for guiding the liquid sample into and away from the sample receiving space; a sensor device including a sample detecting unit that is disposed in the sample receiving space, and that is operable to detect the liquid sample and to generate a detection signal accordingly, and a signal conducting unit that is connected electrically to the sensor device for conducting the detection signal therefrom; and a liquid introducing unit and a liquid discharging unit coupled to the inlet and outlet channels and cooperating therewith to form an introducing path and a discharging path for introducing the liquid sample into and for discharging the liquid sample from the sample receiving space, respectively.

摘要翻译： 提供了一种用于检测液体样品的系统，包括：形成有样品容纳空间的流通池组件，以及延伸到样品容纳空间的入口和出口通道，用于将液体样品引入和离开样品接收空间; 传感器装置，包括：样本检测单元，其设置在样本容纳空间中，并且可操作地检测液体样本并相应地产生检测信号;以及信号导通单元，其与传感器装置电连接，用于导电 检测信号; 以及液体引入单元和液体排出单元，其联接到入口和出口通道并与之配合以形成引入路径和用于将液体样品分别从样品接收空间引入和排出液体样品的排出路径。

公开(公告)号：US20120266662A1

公开(公告)日：2012-10-25

申请号：US13091435

申请日：2011-04-21

申请人： Chi-Yen Shen ,  Ke-Nung Huang ,  Shen-Li Fu ,  Jian-Jhong Chen ,  Yu-Fong Huang

发明人： Chi-Yen Shen ,  Ke-Nung Huang ,  Shen-Li Fu ,  Jian-Jhong Chen ,  Yu-Fong Huang

IPC分类号： G01N1/10

CPC分类号： G01N33/54306 ,  G01N33/4915 ,  G01N35/1095

摘要： A system is provided for detecting a liquid sample, and includes: a flow cell assembly formed with a sample receiving space therein, and inlet and outlet channels extending to the sample receiving space for guiding the liquid sample into and away from the sample receiving space; a sensor device including a sample detecting unit that is disposed in the sample receiving space, and that is operable to detect the liquid sample and to generate a detection signal accordingly, and a signal conducting unit that is connected electrically to the sensor device for conducting the detection signal therefrom; and a liquid introducing unit and a liquid discharging unit coupled to the inlet and outlet channels and cooperating therewith to form an introducing path and a discharging path for introducing the liquid sample into and for discharging the liquid sample from the sample receiving space, respectively.

摘要翻译： 提供了一种用于检测液体样品的系统，包括：形成有样品容纳空间的流通池组件，以及延伸到样品容纳空间的入口和出口通道，用于将液体样品引入和离开样品接收空间; 传感器装置，包括：样本检测单元，其设置在样本容纳空间中，并且可操作地检测液体样本并相应地产生检测信号;以及信号导通单元，其与传感器装置电连接，用于导电 检测信号; 以及液体引入单元和液体排出单元，其联接到入口和出口通道并与之配合以形成引入路径和用于将液体样品分别从样品接收空间引入和排出液体样品的排出路径。

公开(公告)号：US20120199479A1

公开(公告)日：2012-08-09

申请号：US13020177

申请日：2011-02-03

申请人： Chi-Yen Shen ,  Jian-Jhong Chen ,  Yu-Fong Huang

发明人： Chi-Yen Shen ,  Jian-Jhong Chen ,  Yu-Fong Huang

IPC分类号： G01N27/28

CPC分类号： G01N27/08

摘要： A flow cell device is formed with: a plurality of cell recess portions adapted to cooperate with a plurality of sensor devices to confine a plurality of sample receiving space for receiving a liquid sample, respectively; a plurality of pairs of first and second guiding channels, each pair being in fluid communication with a respective one of the cell recess portions; a number of connecting recess portions each fluidly communicating the first and second guiding channels that respectively extend to a corresponding pair of the cell recess portions such that the liquid sample is able to flow through the sample receiving spaces sequentially; and inlet and outlet channels in fluid communication with the first and second guiding channels that respectively extend to a first one and a last one of the cell recess portions for introducing and discharging the liquid sample into and from the flow cell device, respectively.

摘要翻译： 流动池装置形成有：多个单元凹部，其适于与多个传感器装置配合，以分别限制用于接收液体样品的多个样品接收空间; 多对第一和第二引导通道，每对引导通道与相应的单元凹槽部分流体连通; 多个连接凹部，其各自流体地连通所述第一和第二引导通道，所述第一和第二引导通道分别延伸到相应的一对所述单元凹槽部分，使得所述液体样品能够依次流过所述样品接收空间; 以及分别与第一和第二引导通道流体连通的入口和出口通道，其分别延伸到第一个和第二个单元凹槽部分，用于将液体样本分别引入和从流动池装置排出。

公开(公告)号：US08241570B1

公开(公告)日：2012-08-14

申请号：US13020177

申请日：2011-02-03

申请人： Chi-Yen Shen ,  Jian-Jhong Chen ,  Yu-Fong Huang

发明人： Chi-Yen Shen ,  Jian-Jhong Chen ,  Yu-Fong Huang

IPC分类号： G01N15/06

CPC分类号： G01N27/08

摘要： A flow cell device is formed with: a plurality of cell recess portions adapted to cooperate with a plurality of sensor devices to confine a plurality of sample receiving space for receiving a liquid sample, respectively; a plurality of pairs of first and second guiding channels, each pair being in fluid communication with a respective one of the cell recess portions; a number of connecting recess portions each fluidly communicating the first and second guiding channels that respectively extend to a corresponding pair of the cell recess portions such that the liquid sample is able to flow through the sample receiving spaces sequentially; and inlet and outlet channels in fluid communication with the first and second guiding channels that respectively extend to a first one and a last one of the cell recess portions for introducing and discharging the liquid sample into and from the flow cell device, respectively.

摘要翻译： 流动池装置形成有：多个单元凹部，其适于与多个传感器装置配合，以分别限制用于接收液体样品的多个样品接收空间; 多对第一和第二引导通道，每对引导通道与相应的单元凹槽部分流体连通; 多个连接凹部，其各自流体地连通所述第一和第二引导通道，所述第一和第二引导通道分别延伸到相应的一对所述单元凹槽部分，使得所述液体样品能够依次流过所述样品接收空间; 以及分别与第一和第二引导通道流体连通的入口和出口通道，其分别延伸到第一个和第二个单元凹槽部分，用于将液体样本分别引入和从流动池装置排出。

公开(公告)号：US07459094B2

公开(公告)日：2008-12-02

申请号：US11675751

申请日：2007-02-16

申请人： Chi-Yen Shen

发明人： Chi-Yen Shen

IPC分类号： B44C1/22 ,  C23F1/00 ,  H01L21/00

CPC分类号： H03H3/08 ,  C23F1/02 ,  H01L2224/48091 ,  H01L2924/16195 ,  H01L2924/181 ,  H03H9/0542 ,  H03H9/059 ,  H03H9/1085 ,  H03H9/1092 ,  H01L2924/00014 ,  H01L2924/00012

摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.

摘要翻译： 一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

公开(公告)号：US07198725B2

公开(公告)日：2007-04-03

申请号：US10982204

申请日：2004-11-05

申请人： Chi-Yen Shen

发明人： Chi-Yen Shen

IPC分类号： B44C1/22 ,  C23F1/00

CPC分类号： H03H3/08 ,  C23F1/02 ,  H01L2224/48091 ,  H01L2924/16195 ,  H01L2924/181 ,  H03H9/0542 ,  H03H9/059 ,  H03H9/1085 ,  H03H9/1092 ,  H01L2924/00014 ,  H01L2924/00012

摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.

摘要翻译： 一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

公开(公告)号：US20120047994A1

公开(公告)日：2012-03-01

申请号：US12942845

申请日：2010-11-09

申请人： Chi-Yen Shen ,  Shih-Han Wang

发明人： Chi-Yen Shen ,  Shih-Han Wang

IPC分类号： G01N29/02 ,  H01L41/22

CPC分类号： H01L41/1132 ,  G01N29/022 ,  G01N2291/021 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02809 ,  G01N2291/0423 ,  G01N2291/045 ,  Y10T29/42

摘要： A nitrogenous gas sensor comprises a piezoelectricity plate which has a sensing surface; two transducers placed on the sensing surface of the piezoelectricity plate for transduction of electrostatic potential energy and acoustic energy, in order to generate surface acoustic waves on the piezoelectricity plate; and a sensing layer installed on the sensing surface of the piezoelectricity plate between the two transducers, which is consisted of polyaniline and tungsten oxide. Furthermore, a manufacturing method of the nitrogenous gas sensor comprises a step of “manufacturing transducer,” by placing two transducers on the sensing surface of the piezoelectric plate; and a step of “manufacturing sensing layer,” by mixing a solution of polyaniline and a solution of tungsten oxide to obtain a mixture of polyaniline and tungsten oxide, and further generating a sensing layer consisted of nano-scaled of complex polyaniline and tungsten oxide between the two transducer by dropping the mixture of polyaniline and tungsten oxide on the sensing surface of the piezoelectric plate.

摘要翻译： 含氮气体传感器包括具有感测表面的压电板; 两个换能器放置在压电板的感测表面上，用于转换静电势能和声能，以便在压电板上产生表面声波; 以及安装在由聚苯胺和氧化钨组成的两个换能器之间的压电板的感测表面上的感测层。 此外，氮气传感器的制造方法包括通过将两个换能器放置在压电板的感测表面上的“制造换能器”的步骤; 和“制造感测层”的步骤，通过混合聚苯胺溶液和氧化钨溶液以获得聚苯胺和氧化钨的混合物，并进一步产生由纳米级的复合聚苯胺和氧化钨组成的感测层，介于 通过将聚苯胺和氧化钨的混合物滴落在压电板的感测表面上的两个换能器。

公开(公告)号：US20070187360A1

公开(公告)日：2007-08-16

申请号：US11675751

申请日：2007-02-16

申请人： Chi-Yen Shen

发明人： Chi-Yen Shen

IPC分类号： C23F1/00 ,  B44C1/22

CPC分类号： H03H3/08 ,  C23F1/02 ,  H01L2224/48091 ,  H01L2924/16195 ,  H01L2924/181 ,  H03H9/0542 ,  H03H9/059 ,  H03H9/1085 ,  H03H9/1092 ,  H01L2924/00014 ,  H01L2924/00012

摘要： A method for making a SAW device package includes the steps of: forming a pattern of a metal layer, that defines transmitting and receiving transducers of a SAW die, on a wafer; forming a pattern of a first photo sensitive layer, which defines a peripheral wall of a cap of the SAW die, on the metal layer and the wafer through lithography techniques; forming a pattern of a second photo sensitive layer, which defines a cover wall of the cap of the SAW die, on the first photo sensitive layer through lithography techniques; curing the first and second photo sensitive layers; dicing the wafer into SAW dies; and encapsulating the SAW dies with a molding compound.

摘要翻译： 一种用于制造SAW器件封装的方法包括以下步骤：在晶片上形成限定SAW模具的发射和接收换能器的金属层的图案; 通过光刻技术在金属层和晶片上形成限定SAW管芯盖的外围壁的第一光敏层的图案; 通过光刻技术在第一光敏层上形成限定SAW模具的盖的盖壁的第二光敏层的图案; 固化第一和第二光敏层; 将晶片切割成SAW模具; 并用模塑料包封SAW模具。

公开(公告)号：US20060113874A1

公开(公告)日：2006-06-01

申请号：US10982235

申请日：2004-11-05

申请人： Chi-Yen Shen

发明人： Chi-Yen Shen

IPC分类号： H01L41/053

CPC分类号： H03H9/059 ,  H01L2224/16245 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2924/16235 ,  H01L2924/181 ,  H03H3/08 ,  H03H9/0542 ,  H03H9/0585 ,  H03H9/1085 ,  H03H9/1092 ,  H01L2924/00014 ,  H01L2924/00012

摘要： A SAW device package includes a SAW die, a molding compound, and conductive leads. The SAW die includes a piezoelectric substrate having a transducer-mounting surface, transmitting and receiving transducers that are formed on the transducer-mounting surface and that have conductive connecting pads, and a cap that is formed on and that is reduced in size from the transducer-mounting surface and that cooperates with the substrate to define an embedded air cavity therebetween in such a manner that the transmitting and receiving transducers are confined in the embedded air cavity. The SAW die is encapsulated by the molding compound. The leads are connected electrically to the connecting pads and extend outwardly of the molding compound.

摘要翻译： SAW器件封装包括SAW模具，模塑料和导电引线。 SAW管芯包括具有换能器安装表面的压电基片，传输和接收形成在换能器安装表面上并且具有导电连接焊盘的换能器，以及形成在其上并且与传感器尺寸相比尺寸减小的盖 并且与衬底配合以在其间限定嵌入的空气腔，使得发射和接收换能器被限制在嵌入式空气腔中。 SAW模具被模塑料封装。 引线电连接到连接焊盘并且延伸到模制化合物的外部。

公开(公告)号：US09005912B2

公开(公告)日：2015-04-14

申请号：US13562123

申请日：2012-07-30

申请人： Chih-Hsin Hung ,  Chi-Yen Shen ,  Shyh-Ming Kuo ,  I-Fen Chen ,  Shih-Han Wang

发明人： Chih-Hsin Hung ,  Chi-Yen Shen ,  Shyh-Ming Kuo ,  I-Fen Chen ,  Shih-Han Wang

IPC分类号： C07K16/18 ,  G01N33/68 ,  G01N33/543 ,  C07K14/78

CPC分类号： C07K16/18 ,  C07K14/78 ,  C07K2317/34 ,  G01N33/543 ,  G01N33/6887 ,  G01N2333/78 ,  G01N2800/105

摘要： The present invention provides a hybridoma cell line (DSM ACC3145), wherein the hybridoma cell line produces an antibody which specifically binds to an amino acid sequence of type II collagen comprising: K-G-E-P-G-D-D-G-P-S-C (as set forth in SEQ ID NO. 1); and a method for detecting osteoarthritis, by identifying a presence of type II collagen in a urine sample through containing the urine sample with the said antibody.

摘要翻译： 本发明提供了一种杂交瘤细胞系（DSM ACC3145），其中杂交瘤细胞系产生特异性结合II型胶原的氨基酸序列的抗体，其包含：K-G-E-P-G-D-D-G-P-S-C（如SEQ ID NO.1所示） 以及通过用所述抗体含有尿液样品来鉴定尿液样品中II型胶原蛋白的存在来检测骨关节炎的方法。