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公开(公告)号：US20130197219A1
公开(公告)日：2013-08-01
申请号：US13824723
申请日：2011-09-21
申请人： Chika Takahashi , Hidenori Mikamiyama , Toshiyuki Akiyama , Kenji Tomita , Yoshiyuki Taoda , Makoto Kawai , Kosuke Anan , Masayoshi Miyagawa , Naoyuki Suzuki
发明人： Chika Takahashi , Hidenori Mikamiyama , Toshiyuki Akiyama , Kenji Tomita , Yoshiyuki Taoda , Makoto Kawai , Kosuke Anan , Masayoshi Miyagawa , Naoyuki Suzuki
IPC分类号： C07D471/04 , C07F9/6561
CPC分类号： C07D471/04 , A61K31/4738 , C07D471/14 , C07F9/6561 , C07F9/65616
摘要： The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.
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公开(公告)号：US08987441B2
公开(公告)日：2015-03-24
申请号：US13824723
申请日：2011-09-21
申请人： Chika Takahashi , Hidenori Mikamiyama , Toshiyuki Akiyama , Kenji Tomita , Yoshiyuki Taoda , Makoto Kawai , Kosuke Anan , Masayoshi Miyagawa , Naoyuki Suzuki
发明人： Chika Takahashi , Hidenori Mikamiyama , Toshiyuki Akiyama , Kenji Tomita , Yoshiyuki Taoda , Makoto Kawai , Kosuke Anan , Masayoshi Miyagawa , Naoyuki Suzuki
IPC分类号： C07D413/00 , C07D253/08 , C07D471/00 , C07D241/04 , C07D471/04 , C07F9/6561 , C07D471/14
CPC分类号： C07D471/04 , A61K31/4738 , C07D471/14 , C07F9/6561 , C07F9/65616
摘要： The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3-hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.
摘要翻译： 本发明提供具有抗病毒作用的化合物，特别是具有对流感病毒的生长抑制活性的化合物，该化合物的优选实例是具有cap依赖性内切核酸酶抑制活性的取代的3-羟基-4-吡啶酮衍生物前药。
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公开(公告)号：US20120022069A1
公开(公告)日：2012-01-26
申请号：US13260185
申请日：2010-04-02
IPC分类号： A61K31/445 , C07D401/12 , A61K31/4545 , C07D405/12 , A61K31/4525 , C07D409/12 , C07D265/30 , A61K31/5375 , A61P25/00 , A61P25/08 , A61P25/06 , A61P25/18 , A61P25/28 , A61P25/24 , A61P25/22 , A61P9/12 , A61P9/06 , C07D211/96
CPC分类号： C07D211/70 , C07D211/96
摘要： The invention relates to acrylamide compounds of Formula I mentioned below.The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及下述式I的丙烯酰胺化合物。 本发明还涉及使用式I化合物来治疗或预防对阻塞钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。
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公开(公告)号：US08895551B2
公开(公告)日：2014-11-25
申请号：US13260185
申请日：2010-04-02
IPC分类号： A61K31/5377 , C07D265/30 , A61K31/445 , C07D211/68 , C07D401/00 , C07D405/00 , C07D211/70 , C07D211/96
CPC分类号： C07D211/70 , C07D211/96
摘要： The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
摘要翻译： 本发明涉及下述式I的丙烯酰胺化合物。 本发明还涉及使用式I化合物来治疗或预防对阻塞钙通道，特别是N型钙通道有响应的病症。 本发明的化合物特别适用于治疗疼痛。
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