-
公开(公告)号：US07708014B2
公开(公告)日：2010-05-04
申请号：US10538176
申请日：2003-12-12
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0033 , A61M2202/064 , A61M2206/16
摘要： An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).
摘要翻译： 用于经肺给药的吸入装置包括：用于容纳药物组合物的室（16），其通过空气产生的冲击粉碎成细颗粒以分散在空气中; 空气入口流路（2），用于将空气产生的冲击施加到药物组合物上并将外部空气注入药物组合物; 用于吸入粉碎的药物组合物的吸入流路（1）; 用于容纳腔室（16）的壳体（9），空气入口流路（2）和吸入流路（1）; 设置在所述壳体（9）的一端的接口（10），所述接口（9）设置有与所述吸入流路（1）连通的口侧流路（11）和辅助流路 12）。
-
公开(公告)号：US08333193B2
公开(公告)日：2012-12-18
申请号：US12202221
申请日：2008-08-30
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/40 , A61M11/001 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
摘要翻译： 本发明提供一种适用于经肺给药的新型干粉吸入系统。 本发明的干粉吸入系统的特征在于使用以下组合的组合：（1）容纳含有单剂量活性成分的冷冻干燥组合物的容器，并具有：（i）非粉饼样形式 ，（ii）0.015以上的崩解指数，（iii）在接收到具有空气冲击的空气冲击时，成为平均粒径为10微米以下的细颗粒或微细粒子分数为10％以上的性质 空气速度至少为1米/秒，空气流速为至少17毫升/秒; 和（2）包括能够将所述空气冲击施加到所述容器中的冷冻干燥组合物的装置的装置，以及用于将已制成微粒的粉末状冻干组合物排出的装置。
-
3.发明授权Composition, vessel, dry powder inhalation system, and related methods for transpulmonary administration 失效成分，血管，干粉吸入系统及相关的肺部给药方法公开(公告)号：US07448379B2
公开(公告)日：2008-11-11
申请号：US10170339
申请日：2002-06-14
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/40 , A61M11/001 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： A non-powder-form freeze-dried composition for transpulmonary administration has a disintegration index greater than or equal to 0.015 and contains at least one active ingredient. The composition becomes fine particles upon receiving air impact at an air speed greater than or equal to 1 meter/second and an air flow rate greater than or equal to 17 milliliters/second. The fine particles have a mean particle diameter less than or equal to 1×10−5 meters and/or a fine particle fraction greater than or equal to 10%. A method of making the composition, a vessel containing the composition, a method of administering the composition, a dry powder inhalation system for transpulmonary administration, and a method of transpulmonary administration are also disclosed.
摘要翻译： 用于经肺给药的非粉末状冻干组合物具有大于或等于0.015的崩解指数，并且含有至少一种活性成分。 以大于或等于1米/秒的空气速度接收空气冲击并且空气流速大于或等于17毫升/秒时，组合物变成细颗粒。 细颗粒具有小于或等于1×10 -5米的平均粒径和/或大于或等于10％的细颗粒分数。 还公开了制备组合物的方法，含有该组合物的容器，施用组合物的方法，用于经肺给药的干粉吸入系统和经肺给药的方法。
-
公开(公告)号：US20090095293A1
公开(公告)日：2009-04-16
申请号：US12202221
申请日：2008-10-10
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/40 , A61M11/001 , A61M11/02 , A61M15/0028 , A61M15/0036 , A61M15/004 , A61M2202/064 , A61M2205/071 , A61M2205/075
摘要： The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
摘要翻译： 本发明提供一种适用于经肺给药的新型干粉吸入系统。 本发明的干粉吸入系统的特征在于使用以下组合的组合：（1）容纳含有单剂量活性成分的冷冻干燥组合物的容器，并具有：（i）非粉饼样形式 ，（ii）0.015以上的崩解指数，（iii）在接收到具有空气冲击的空气冲击时，成为平均粒径为10微米以下的细颗粒或微细粒子分数为10％以上的性质 空气速度至少为1米/秒，空气流速为至少17毫升/秒; 和（2）包括能够将所述空气冲击施加到所述容器中的冷冻干燥组合物的装置的装置，以及用于将已制成微粒的粉末状冻干组合物排出的装置。
-
公开(公告)号：US08443799B2
公开(公告)日：2013-05-21
申请号：US12202220
申请日：2008-08-30
IPC分类号： A61M15/00
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/40 , A61M11/001 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： A dry powder inhalation system suitable for transpulmonary administration characterized by using a combination of: (1) A vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) A device capable of applying said air impact to the freeze-dried composition in said vessel and for discharging the powder-form freeze-dried composition that has been made into fine particles.
摘要翻译： 适用于经肺给药的干粉吸入系统，其特征在于使用以下组合的组合：（1）容纳含有单剂量活性成分的冷冻干燥组合物的容器，并具有：（i）非粉饼状 形式，（ii）0.015以上的崩解指数，以及（iii）当接收到具有空气冲击的平均粒径为10微米或更小的细颗粒或10％或更多的细颗粒分数时， 至少1m / sec的空气速度和至少17ml / sec的空气流速; 和（2）一种能够将所述空气冲击施加到所述容器中的冷冻干燥组合物并将已经制成细颗粒的粉末状冻干组合物排出的装置。
-
公开(公告)号：US20090126732A1
公开(公告)日：2009-05-21
申请号：US12202220
申请日：2008-08-30
IPC分类号： A61M15/00
CPC分类号： A61K9/0075 , A61K9/0073 , A61K9/19 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/26 , A61K47/40 , A61M11/001 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： The present invention provides a novel dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system of the invention characterized by using a combination of: (1) a vessel housing a freeze-dried composition that contains a single dose of an active ingredient, and has: (i) a non-powder cake-like form, (ii) a disintegration index of 0.015 or more, and (iii) a property of becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and (2) a device comprising means capable of applying said air impact to the freeze-dried composition in said vessel, and means for discharging the powder-form freeze-dried composition that has been made into fine particles.
-
公开(公告)号：US20060169280A1
公开(公告)日：2006-08-03
申请号：US10538176
申请日：2003-12-12
CPC分类号： A61M15/0028 , A61M11/001 , A61M15/0033 , A61M2202/064 , A61M2206/16
摘要： An inhalation device for transpulmonary administration comprises: a chamber (16) for containing a pharmaceutical composition which is pulverized into fine particles by an air-generated impact for dispersal in air; an air inlet flow path (2) for introducing to the chamber (16) outside air to apply the air-generated impact to the pharmaceutical composition and for injecting the outside air toward the pharmaceutical composition; an inhalation flow path (1) for inhaling the pulverized pharmaceutical composition; a housing (9) for accommodating the chamber (16), the air inlet flow path (2), and the inhalation flow path (1); a mouthpiece (10) provided at one end of the housing (9), the mouthpiece (9) being provided with a mouth-side flow path (11) which communicates with the inhalation flow path (1), and an auxiliary flow path (12).
摘要翻译： 用于经肺给药的吸入装置包括：用于容纳药物组合物的室（16），其通过空气产生的冲击粉碎成细颗粒以分散在空气中; 空气入口流路（2），用于将空气产生的冲击施加到药物组合物上并将外部空气注入药物组合物; 用于吸入粉碎的药物组合物的吸入流路（1）; 用于容纳腔室（16）的壳体（9），空气入口流路（2）和吸入流路（1）; 设置在所述壳体（9）的一端的接口（10），所述接口（9）设置有与所述吸入流路（1）连通的口侧流路（11）和辅助流路 12）。
-
8.发明申请Freeze-dried interferon-y composition for transpulmonary administration and inhalation system therefor 审中-公开用于经肺给药和吸入系统的冷冻干燥素组合物公开(公告)号：US20060057106A1
公开(公告)日：2006-03-16
申请号：US10538781
申请日：2003-12-12
IPC分类号： A61K38/21
CPC分类号： A61K9/0075 , A61K9/19 , A61K38/217 , A61K47/183 , A61M11/001 , A61M15/0028 , A61M15/0033 , A61M2202/064 , A61M2205/075
摘要： The present invention provides a freeze-dried interferon-γ composition for transpulmonary administration which can maintain IFN-γ stably, and can be prepared into fine particles in a vessel at the time of use. A freeze-dried interferon-γ composition for transpulmonary administration of the present invention has the following properties (i) to (iv): (i) containing at least one hydrophobic stabilizer selected from the group consisting of hydrophobic amino acids, dipeptides of hydrophobic amino acids, tripeptides of hydrophobic amino acids and derivatives of hydrophobic amino acids and salts thereof; at least one hydrophilic stabilizer selected from the group consisting of hydrophilic amino acids, dipeptides of hydrophilic amino acids, tripeptides of hydrophilic amino acids, derivatives of hydrophilic amino acids and salts thereof; and interferon-γ(ii) a non-powder cake-like form; (iii) a disintegration index of 0.015 or more; and (iv) becoming fine particles having a mean particle diameter of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec.
摘要翻译： 本发明提供了用于经肺给药的冷冻干燥的干扰素-γ组合物，其可以稳定地维持IFN-γ，并且可以在使用时在容器中制备成细小颗粒。 本发明的用于经肺给药的冷冻干燥素-γ组合物具有以下性质（i）至（iv）：（i）含有至少一种选自疏水性氨基酸，疏水性氨基的二肽 酸，疏水性氨基酸的三肽和疏水性氨基酸的衍生物及其盐; 选自亲水氨基酸，亲水氨基酸二肽，亲水氨基酸三肽，亲水氨基酸衍生物及其盐的至少一种亲水稳定剂; 和干扰素-γ（ii）非粉饼样形式; （iii）崩解指数为0.015以上; 和（iv）在接收到具有至少1m / sec的空气速度和空气速度的空气冲击时，成为平均粒径为10微米或更小的细颗粒或10％或更多的细颗粒分数， 至少17毫升/秒。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.026 秒)
