公开(公告)号：US20150030659A1

公开(公告)日：2015-01-29

申请号：US14496742

申请日：2014-09-25

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L31/06 ,  A61L31/14 ,  A61L31/16

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US08858966B2

公开(公告)日：2014-10-14

申请号：US14177888

申请日：2014-02-11

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61K9/00 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61F2/02

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US20160339150A1

公开(公告)日：2016-11-24

申请号：US15229551

申请日：2016-08-05

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/50 ,  A61L27/38 ,  A61L27/54 ,  A61L27/26 ,  A61L27/18 ,  A61L27/58

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US20150297799A1

公开(公告)日：2015-10-22

申请号：US14694466

申请日：2015-04-23

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L31/06 ,  A61L31/14 ,  A61F2/44 ,  A61L31/00 ,  A61F2/02 ,  A61L31/16 ,  A61L31/04

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US20190038808A1

公开(公告)日：2019-02-07

申请号：US16153139

申请日：2018-10-05

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/50 ,  A61L27/26 ,  A61K9/00 ,  A61L31/06 ,  A61L27/56 ,  A61L27/58 ,  A61L31/04 ,  A61L27/38 ,  A61L27/18 ,  A61L31/14 ,  A61L31/00 ,  A61F2/02 ,  A61F2/44 ,  A61L27/54 ,  A61L31/16 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US09440008B2

公开(公告)日：2016-09-13

申请号：US14694466

申请日：2015-04-23

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61F13/00 ,  A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16 ,  A61F2/44 ,  A61L31/00 ,  A61L31/04

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

公开(公告)号：US09101695B2

公开(公告)日：2015-08-11

申请号：US14496742

申请日：2014-09-25

申请人： Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L31/06 ,  A61K9/00 ,  A61F2/02 ,  A61L31/14 ,  A61L27/26 ,  A61L27/58 ,  A61L31/16

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US20140161861A1

公开(公告)日：2014-06-12

申请号：US14177888

申请日：2014-02-11

申请人： Massachusetts Institute of Technology ,  Children's Medical Center Corporation

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/58 ,  A61L27/26

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US20130129796A1

公开(公告)日：2013-05-23

申请号：US13741901

申请日：2013-01-15

申请人： Massachusetts Institute of Technology ,  Children s Medical Center Corporation

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/58 ,  A61L27/26

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.

摘要翻译： 公开了用于治疗开放和闭合伤口脊髓损伤的装置和方法。 例如，本文描述了用于减轻脊髓原发性损伤的继发性损伤并促进恢复的装置和方法。 更具体地，本发明的某些实施方案涉及可用于治疗脊髓损伤的聚合物微型管。 此外，其它实施方案涉及可用于治疗脊髓损伤的聚合物“填充”绷带。 例如，制造本发明的可侵蚀或可生物降解的生物相容性聚合物形式用于外科植入到脊髓损伤部位。

公开(公告)号：US20180169302A1

公开(公告)日：2018-06-21

申请号：US15896948

申请日：2018-02-14

申请人： Children`s Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： Robert S. Langer ,  Rajiv Saigal ,  Yang Teng

IPC分类号： A61L27/50 ,  A61L27/26 ,  A61L31/14 ,  A61K9/00 ,  A61L27/54 ,  A61L27/38 ,  A61L31/00 ,  A61F2/44 ,  A61L27/56 ,  A61L27/18 ,  A61L31/06 ,  A61L27/58 ,  A61L31/16 ,  A61F2/02 ,  A61L31/04 ,  C08L67/04

CPC分类号： A61L27/50 ,  A61F2/02 ,  A61F2/442 ,  A61F2210/0004 ,  A61K9/0085 ,  A61L27/18 ,  A61L27/26 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/3878 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/005 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/60 ,  A61L2300/606 ,  A61L2300/64 ,  A61L2300/802 ,  A61L2400/00 ,  A61L2430/38 ,  C08L67/04

摘要： Devices and methods for the treatment of open and closed wound spinal cord injuries are disclosed. For example, described herein are devices and methods for mitigating secondary injury to, and promoting recovery of, spinal cord primary injuries. More particularly, certain embodiments of the present invention are directed to polymeric mini-tubes that may be used for the treatment of spinal cord injuries. In addition, other embodiments are directed to polymeric “fill-in” bandages that may be used for the treatment of spinal cord injuries. For example, an erodible, or biodegradable, form of biocompatible polymer of the present invention is fabricated for surgical implantation into the site of the spinal cord injury.