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1.发明授权Detection of antibody that binds to water soluble polymer-modified polypeptides 有权检测结合水溶性聚合物修饰多肽的抗体公开(公告)号：US08216793B2
公开(公告)日：2012-07-10
申请号：US12786641
申请日：2010-05-25
申请人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： G01N33/566
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。
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2.发明申请DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES 审中-公开检测抗水溶性聚合物改性多糖的抗体公开(公告)号：US20120309021A1
公开(公告)日：2012-12-06
申请号：US13489925
申请日：2012-06-06
申请人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： G01N33/566 , G01N33/573
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。
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3.发明申请公开(公告)号：US20110070592A1
公开(公告)日：2011-03-24
申请号：US12786641
申请日：2010-05-25
申请人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人： Christian Lubich , Juergen Siekmann , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号： G01N33/566
CPC分类号： G01N33/6854
摘要： The present invention provides analytical methods for detecting anti-polymer antibody in an individual. The methods involve contacting a sample from the individual with a water soluble polymer-modified carrier and detecting binding of antibody to the water soluble polymer on the water soluble polymer-modified carrier wherein binding is indicative of the presence of antibody to the water polymer-modified polypeptide. Antibody may be detected to water soluble polymers such as polyethylene glycol, polysialic acid, dextran, hydroxyalkyl starch, or hydroxyethyl starch. When antibody to the water soluble polymer polyethylene glycol is to be detected, the carrier is modified with a non-linear polyethylene glycol derivative.
摘要翻译： 本发明提供了检测个体抗体抗体的分析方法。 所述方法包括使来自个体的样品与水溶性聚合物修饰的载体接触并检测抗体与水溶性聚合物修饰的载体上的水溶性聚合物的结合，其中结合指示抗体存在于聚合物修饰的水 多肽。 可以对水溶性聚合物如聚乙二醇，聚唾液酸，葡聚糖，羟烷基淀粉或羟乙基淀粉检测抗体。 当检测到对水溶性聚合物聚乙二醇的抗体时，用非线性聚乙二醇衍生物修饰载体。
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4.发明申请METHODS OF DETERMINING POLYDISPERSITY AND/OR MOLECULAR WEIGHT DISTRIBUTION OF A POLYETHYLENE GLYCOL SAMPLE 审中-公开确定聚乙二醇样品多聚性和/或分子量分布的方法公开(公告)号：US20100126866A1
公开(公告)日：2010-05-27
申请号：US12621051
申请日：2009-11-18
申请人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
发明人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
IPC分类号： B01D59/42
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
摘要翻译： 本文公开了使用质谱测定反应性PEG样品的多分散性（PDI）和分子量分布（MMD）的方法。 更具体地，使用称为GEMMA的质谱法来测定PEG样品的PDI和MMD，其提供了比现有已知的MALDI-TOF分析更高精度的高分子量PEG样品的测量。
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公开(公告)号：US6017891A
公开(公告)日：2000-01-25
申请号：US924533
申请日：1997-09-05
CPC分类号： B82Y5/00 , C12N9/6424 , C12N9/96
摘要： The invention relates to a stable preparation which comprises a protein, such as thrombin, that is bound in and/or on (i.e., to) lipid vesicles and that was treated for the inactivation of potentially present viruses. Further, the invention relates to methods for the production of a stable preparation for the treatment of blood coagulation disorders, wherein a protein is bound in and/or on lipid vesicles, and the method comprises a step in which the protein lipid complex is subjected to a treatment for the inactivation of potentially present viruses.
摘要翻译： 本发明涉及一种稳定的制剂，其包含结合于脂质囊泡中和/或上（即）脂质囊泡上的蛋白质，例如凝血酶，并且被处理用于灭活潜在的存在的病毒。 此外，本发明涉及生产用于治疗凝血障碍的稳定制剂的方法，其中蛋白质与脂质囊泡中和/或结合，该方法包括将蛋白质脂质复合物经受 用于灭活潜在存在的病毒的治疗。
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6.发明授权Method of chromatographically purifying or fractionating, respectively, von Willebrand factor from a VWF-containing starting material 失效分别从含VWF的起始材料中色谱纯化或分馏von Willebrand因子的方法公开(公告)号：US06414125B1
公开(公告)日：2002-07-02
申请号：US09355865
申请日：1999-10-21
申请人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
发明人： Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Johann Eibl , Bernhard Fischer , Artur Mitterer , Friedrich Dorner
IPC分类号： A23J100
CPC分类号： C07K14/755
摘要： Disclosed is a method of chromatographically purifying or fractionating, respectively, von Willebrand factor (vWF) from a vWF-containing starting material, comprising the following steps: adsorbing the vWF from the starting material on avid collagen immobilized on a carrier, separating the non-adsorbed portion and, optionally, washing the carrier, eluting the vWF from immobilized collagen, and recovering the purified vWF, as well as a pharmaceutical preparation comprising biologically active vWF which is bound to collagen in a stable manner.
摘要翻译： 公开了一种从含有vWF的原料分别纯化或分馏von Willebrand因子（vWF）的方法，其包括以下步骤：将起始材料的vWF吸附在固定在载体上的avid胶原上， 吸附部分和任选地洗涤载体，从固定化胶原洗脱vWF，并回收纯化的vWF，以及包含以稳定方式与胶原结合的生物活性vWF的药物制剂。
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7.发明申请Methods of Determining Polydispersity and/or Molecular Weight Distribution of a Polyethylene Glycol Sample 审中-公开测定聚乙二醇样品的多分散性和/或分子量分布的方法公开(公告)号：US20130043383A1
公开(公告)日：2013-02-21
申请号：US13425481
申请日：2012-03-21
申请人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
发明人： Jasmin Kemptner , Martina Marchetti-Deschmann , Juergen Siekmann , Peter Turecek , Hans-Peter Schwarz , Guenter Allmaier
IPC分类号： H01J49/26
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
摘要翻译： 本文公开了使用质谱测定反应性PEG样品的多分散性（PDI）和分子量分布（MMD）的方法。 更具体地，使用称为GEMMA的质谱法来测定PEG样品的PDI和MMD，其提供了比现有已知的MALDI-TOF分析更高精度的高分子量PEG样品的测量。
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8.发明授权Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage 有权具有释放键的冯维勒布兰因子和因子VIII-聚合物共轭物公开(公告)号：US09493544B2
公开(公告)日：2016-11-15
申请号：US13620285
申请日：2012-09-14
申请人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
发明人： Mary J. Bossard , Gayle Stephenson , Zhihao Fang , Harold Zappe , Stacy Mitchell , Ping Zhang , Friedrich Scheiflinger , Peter Turecek , Juergen Siekmann , Katalin Varadi , Herbert Gritsch
IPC分类号： C07K14/755 , C07K14/745 , C07K17/08 , A61K47/48
CPC分类号： C07K14/755 , A61K47/60
摘要： The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
摘要翻译： 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：US08642737B2
公开(公告)日：2014-02-04
申请号：US13194038
申请日：2011-07-29
申请人： Juergen Siekmann , Stefan Haider , Hanspeter Rottensteiner , Andreas Ivens , Peter Turecek , Oliver Zoechling
发明人： Juergen Siekmann , Stefan Haider , Hanspeter Rottensteiner , Andreas Ivens , Peter Turecek , Oliver Zoechling
IPC分类号： C07K14/62 , C07K14/48 , C07K14/475 , C07K16/00
CPC分类号： C07K1/1077 , A61K47/60 , A61K47/61 , C07K1/20 , C07K1/34 , C07K14/755
摘要： The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
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公开(公告)号：US08076463B2
公开(公告)日：2011-12-13
申请号：US13007208
申请日：2011-01-14
CPC分类号： C07K14/755 , A61K47/60 , C07K14/775
摘要： The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
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