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公开(公告)号：US09670193B2
公开(公告)日：2017-06-06
申请号：US14360013
申请日：2012-11-26
IPC分类号： A61K31/4245 , C07D413/04 , C07D413/14 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , C07D413/04
摘要： The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.
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2.发明申请NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE 有权新型三氟甲基 - 氧杂唑衍生物及其在治疗疾病中的应用公开(公告)号：US20140329825A1
公开(公告)日：2014-11-06
申请号：US14360013
申请日：2012-11-26
IPC分类号： C07D413/14 , C07D413/04 , A61K31/444 , A61K31/4439 , A61K31/497 , A61K31/506
CPC分类号： C07D413/14 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K31/506 , C07D413/04
摘要： The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical combinations thereof, and their use as medicaments, particularly for the treatment of neurodegeneration, muscle atrophy or diabetes/metabolic syndrome via inhibition of HDAC4.
摘要翻译： 本发明涉及式（I）的新型三唑 - 恶二唑衍生物及其药学上可接受的盐，其中所有变量如说明书，其药物组合物，其药物组合，及其作为药物的用途，特别是 通过抑制HDAC4治疗神经变性，肌肉萎缩或糖尿病/代谢综合征。
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公开(公告)号：US20110294799A1
公开(公告)日：2011-12-01
申请号：US12673394
申请日：2008-08-12
IPC分类号： A61K31/4745 , C07D471/14 , A61K31/5377 , A61K31/4375 , A61K31/496 , A61P25/00 , A61P25/22 , A61P25/08 , A61P25/06 , A61P25/24 , A61P25/28 , A61P25/16 , A61P25/18 , A61P1/08 , C07D471/04
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to compound of the formula I in which the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译： 本发明涉及式I化合物，其中取代基如说明书中所定义; 游离碱形式或酸加成盐形式; 作为其制备，用作药物和包含它的药物。
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公开(公告)号：US20140018376A1
公开(公告)日：2014-01-16
申请号：US13502765
申请日：2010-10-20
申请人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
发明人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
IPC分类号： C07D239/96 , C07D403/04 , C07D405/04
CPC分类号： C07D239/96 , C07D403/04 , C07D405/04
摘要： The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of Rasmussen's encephalitis and/or certain forms of epilepsy.
摘要翻译： 本发明涉及竞争性AMPA受体拮抗剂用于治疗，预防或延缓拉斯穆森脑炎和/或某些形式的癫痫发展的用途。
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5.发明授权1H-quinazoline-2,4-diones processes for their production, pharmaceutical compositions, and treatment for epilepsy 失效1H-喹唑啉-2,4-二酮的制备方法，药物组合物和治疗癫痫公开(公告)号：US08513268B2
公开(公告)日：2013-08-20
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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公开(公告)号：US20100179153A1
公开(公告)日：2010-07-15
申请号：US12597100
申请日：2008-04-21
申请人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
发明人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
IPC分类号： A61K31/502 , C07D237/32 , C07D217/24 , A61K31/47 , A61P25/00 , A61P37/00
CPC分类号： C07D237/32 , C07D217/24
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, b their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方法，b用作药物和包含它们的药物。
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公开(公告)号：US20090099244A1
公开(公告)日：2009-04-16
申请号：US12251650
申请日：2008-10-15
申请人： Joachim Nozulak , David Orain
发明人： Joachim Nozulak , David Orain
IPC分类号： A61K31/4178 , C07D233/96 , A61K31/422 , C07D413/02 , A61K31/4166
CPC分类号： C07D233/70 , C07D405/12 , C07D413/12
摘要： The invention relates to compound of the formula I wherein the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicaments comprising it.
摘要翻译： 本发明涉及式I化合物，其中取代基如说明书中所定义; 游离碱形式或酸加成盐形式; 作为其制备，用作药物和包含它的药物。
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8.发明授权Azabicyclic carbamates and their use as &agr;-7 nicotinic acetylcholine receptor agonists 失效氮杂双环氨基甲酸酯及其作为α-7烟碱乙酰胆碱受体激动剂的用途公开(公告)号：US06780861B2
公开(公告)日：2004-08-24
申请号：US10258920
申请日：2002-10-31
申请人： Joachim Nozulak
发明人： Joachim Nozulak
IPC分类号： A61K31495
CPC分类号： C07D453/02
摘要： The invention provides compounds of formula (I) wherein n, A, R1, R2 and R3 are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.
摘要翻译： 本发明提供式（I）化合物，其中n，A，R 1，R 2和R 3如说明书中所定义，及其制备。 式（I）的化合物可用作药物。
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公开(公告)号：US20130303538A1
公开(公告)日：2013-11-14
申请号：US13979987
申请日：2012-01-20
申请人： Joachim Nozulak , Dieter Oser
发明人： Joachim Nozulak , Dieter Oser
IPC分类号： C07D209/08 , A61K45/06 , A61K31/4439 , C07D403/12 , A61K31/4178 , C07D401/12 , A61K31/404 , A61K31/5377
CPC分类号： C07D209/08 , A61K31/404 , A61K31/4178 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D403/12
摘要： The invention relates to compounds of the formula (I) in which the substituents are as defined in the specification; in free form or in salt form; to their preparation, to their use as medicament and to medicaments comprising them.
摘要翻译： 本发明涉及式（I）化合物，其中取代基如说明书中所定义; 以游离形式或盐形式; 用于其制备，用作药物和包含它们的药物。
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10.发明授权Substituted 1H-quinazoline-2,4-diones useful as AMPA receptor ligands 失效可用作AMPA受体配体的取代的1H-喹唑啉-2,4-二酮公开(公告)号：US07655666B2
公开(公告)日：2010-02-02
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
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