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公开(公告)号：US08114591B2
公开(公告)日：2012-02-14
申请号：US11625844
申请日：2007-01-23
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
摘要翻译： 一种在化学反应期间观察反应中间体的方法，包括检测暴露于所述反应的离子敏感场效应晶体管的电信号输出，并监测检测到的电信号以区分电信号中的离散波动，指示反应中间体的离散波动 在化学反应期间发生。
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公开(公告)号：US07888015B2
公开(公告)日：2011-02-15
申请号：US11681212
申请日：2007-03-02
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.
摘要翻译： 使用包含离子敏感场效应晶体管（ISFET）的pH传感器来进行核酸扩增的实时检测/定量，例如， 基于检测在引物延伸期释放的质子的聚合酶链反应（PCR）核酸扩增。
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公开(公告)号：US08698211B2
公开(公告)日：2014-04-15
申请号：US13352063
申请日：2012-01-17
IPC分类号： G01N27/403 , C12M1/00
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
摘要翻译： 一种在化学反应期间观察反应中间体的方法，包括检测暴露于所述反应的离子敏感场效应晶体管的电信号输出，并监测检测到的电信号以区分电信号中的离散波动，指示反应中间体的离散波动 在化学反应期间发生。
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公开(公告)号：US20080032295A1
公开(公告)日：2008-02-07
申请号：US11681212
申请日：2007-03-02
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.
摘要翻译： 使用包含离子敏感场效应晶体管（ISFET）的pH传感器来执行核酸扩增的实时检测/定量，例如， 基于检测在引物延伸期释放的质子的聚合酶链反应（PCR）核酸扩增。
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公开(公告)号：US20100255595A1
公开(公告)日：2010-10-07
申请号：US11625844
申请日：2007-01-23
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： A method of observing reaction intermediaries during a chemical reaction and comprising detecting an electrical signal output from an ion sensitive field effect transistor exposed to said reaction, and monitoring the detected electrical signal to discriminate discrete fluctuations in the electrical signal, the discrete fluctuations indicating reaction intermediaries occurring during a chemical reaction.
摘要翻译： 一种在化学反应期间观察反应中间体的方法，包括检测暴露于所述反应的离子敏感场效应晶体管的电信号输出，并监测检测到的电信号以区分电信号中的离散波动，指示反应中间体的离散波动 在化学反应期间发生。
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公开(公告)号：US08685228B2
公开(公告)日：2014-04-01
申请号：US12711249
申请日：2010-02-23
IPC分类号： G01N27/327
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： A sensing apparatus comprising an ion sensitive field effect transistor arranged to generate an electrical output signal in response to localized fluctuations of ionic charge at or adjacent the surface of the transistor, and means for detecting the electrical output signal from the ion sensitive field effect transistor, the localized fluctuations of ionic charge indicating events occurring during a chemical reaction.
摘要翻译： 一种感测装置，包括离子敏感场效应晶体管，其布置成响应于晶体管的表面处或邻近表面处的离子电荷的局部波动而产生电输出信号，以及用于检测来自离子敏感场效应晶体管的电输出信号的装置， 离子电荷的局部波动指示化学反应期间发生的事件。
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公开(公告)号：US07686929B2
公开(公告)日：2010-03-30
申请号：US10471197
申请日：2002-03-11
IPC分类号： G01N27/327 , G01N27/333 , G01N27/414
CPC分类号： C12Q1/6825 , C12Q2565/607 , G01N27/4145
摘要： A sensing apparatus comprising an ion sensitive field effect transistor arranged to generate an electrical output signal in response to localized fluctuations of ionic charge at or adjacent the surface of the transistor, and means for detecting the electrical output signal from the ion sensitive field effect transistor, the localized fluctuations of ionic charge indicating events occurring during a chemical reaction.
摘要翻译： 一种感测装置，包括离子敏感场效应晶体管，其布置成响应于晶体管的表面处或邻近表面处的离子电荷的局部波动而产生电输出信号，以及用于检测来自离子敏感场效应晶体管的电输出信号的装置， 离子电荷的局部波动指示化学反应期间发生的事件。
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8.发明申请METHOD AND APPARATUS FOR OPTICALLY OUTPUTTING INFORMATION FROM A SEMICONDUCTOR DEVICE 审中-公开用于从半导体器件的光输出信息的方法和装置公开(公告)号：US20130077965A1
公开(公告)日：2013-03-28
申请号：US13576216
申请日：2011-02-01
IPC分类号： H04B10/08
CPC分类号： H04B10/501 , G02F1/015 , G02F2001/0156 , G02F2201/17 , G02F2202/105
摘要： A method of optically outputting information (e.g. digital data) from a semiconductor device, the method comprising: providing a semiconductor device having a semiconducting p-n junction, the p-n junction having a region of reduced free charge carrier density; applying an electrical signal to modulate the extent of the said region, the electrical signal being representative of the information to be outputted; arranging incident light to pass through at least part of the said region, such that the light is at least partially absorbed in dependence upon the modulated extent of the said region, thereby producing intensity-modulated output light; and detecting the intensity of the output light and thereby determining the outputted information. Also provided is an electro-optical assembly, a package module for mounting a semiconductor device on a printed circuit board, and an integrated circuit chip.
摘要翻译： 一种从半导体器件光学输出信息（例如数字数据）的方法，所述方法包括：提供具有半导体p-n结的半导体器件，所述p-n结具有减小的自由电荷载流子密度的区域; 施加电信号来调制所述区域的范围，所述电信号表示要输出的信息; 使入射光穿过所述区域的至少一部分，使得光根据所述区域的调制范围至少部分地被吸收，由此产生强度调制的输出光; 并检测输出光的强度，从而确定输出的信息。 还提供了一种电光学组件，用于将半导体器件安装在印刷电路板上的封装模块和集成电路芯片。
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公开(公告)号：US5352989A
公开(公告)日：1994-10-04
申请号：US62810
申请日：1993-05-11
申请人： Christofer Toumazou , Martin Anding
发明人： Christofer Toumazou , Martin Anding
IPC分类号： H03F3/30
CPC分类号： H03F3/3001 , H03F3/3069
摘要： An amplifier stage suitable for current conveyors and current mode feedback operational amplifiers has low input resistance and operates at low power. The amplifier stage comprises a buffer having inverting and non-inverting inputs and a pair of current outputs, and a pair of multiple output current mirrors which operate in conjunction with the buffer to generate an output current at a high gain node in response to an input signal applied to the buffer inputs. Each multiple output current mirror has a low impedance current input for receiving current signals generated by the buffer and multiple high impedance current outputs for providing current feedback to the inverting input of the buffer and output current to the high gain node of the amplifier stage. The magnitudes of the feedback and output currents are determined by the resistances of current scaling resistors associated with the low impedance current input and each of the high impedance current outputs.
摘要翻译： 适用于当前输送机和电流模式反馈运算放大器的放大器级具有低输入电阻并且以低功率运行。 放大器级包括具有反相和非反相输入和一对电流输出的缓冲器，以及一对多个输出电流镜，其与缓冲器一起工作，以响应于输入在高增益节点处产生输出电流 信号施加到缓冲器输入。 每个多输出电流反射镜具有低阻抗电流输入，用于接收由缓冲器产生的电流信号和多个高阻抗电流输出，用于向缓冲器的反相输入端提供电流反馈，并将输出电流输出到放大器级的高增益节点。 反馈和输出电流的大小由与低阻抗电流输入和每个高阻抗电流输出相关联的电流缩放电阻的电阻决定。
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公开(公告)号：US20130098780A1
公开(公告)日：2013-04-25
申请号：US13576561
申请日：2011-01-28
IPC分类号： G01N27/416
CPC分类号： G01N27/4163 , G01N27/4145 , G01N33/4836
摘要： A sensor system comprising a substrate and integrated onto the substrate an array (7) of sensor elements (1), each sensor element comprising one or more inductors (3), one or more electrochemical sensors (4), and one or more optical sensors (2). The system further comprising a controller configured in use to separately address each of the sensor elements (1) to drive the respective inductors and receive outputs of the respective sensors.
摘要翻译： 一种传感器系统，包括基板并将传感器元件（1）的阵列（7）集成到所述基板上，每个传感器元件包括一个或多个电感器（3），一个或多个电化学传感器（4）和一个或多个光学传感器 （2）。 所述系统还包括控制器，其被配置为用于单独地寻址每个所述传感器元件（1）以驱动相应的电感器并接收各个传感器的输出。
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