公开(公告)号：US08727720B2

公开(公告)日：2014-05-20

申请号：US12827696

申请日：2010-06-30

申请人： Christoph Nagler ,  Jose Anguisola McFeat ,  Sergei Riazantsev ,  Marcel Koenig ,  Erich Kreiselmaier

发明人： Christoph Nagler ,  Jose Anguisola McFeat ,  Sergei Riazantsev ,  Marcel Koenig ,  Erich Kreiselmaier

IPC分类号： F01D9/02

CPC分类号： F01D9/02 ,  F01D5/005 ,  F05D2240/80

摘要： The guide vane of a gas turbine comprises a blade having an outer platform connectable to a guide vane carrier or gas turbine casing, and at the opposite end an inner platform that carries a cover plate. The inner platform has a dovetail housing to which the cover plate is connected. The method for replacing the cover plate consists in separating the cover plate from the inner platform by cutting along the profile of the dovetail housing, then making the cover plate to slide out of the dovetail housing, thus inserting a new or refurbished cover plate into the dovetail housing.

摘要翻译： 燃气轮机的引导叶片包括具有可连接到导向叶片承载件或燃气轮机壳体的外部平台的叶片，并且在相对端具有承载盖板的内部平台。 内平台具有连接盖板的燕尾形外壳。 更换盖板的方法在于通过沿着燕尾形外壳的轮廓切割将盖板与内平台分开，然后使盖板从燕尾壳体滑出，从而将新的或翻新的盖板插入 燕尾屋

公开(公告)号：US20110014054A1

公开(公告)日：2011-01-20

申请号：US12827696

申请日：2010-06-30

申请人： Christoph NAGLER ,  Jose Anguisola Mc Feat ,  Sergei Riazantsev ,  Marcel Koenig ,  Erich Kreiselmaier

发明人： Christoph NAGLER ,  Jose Anguisola Mc Feat ,  Sergei Riazantsev ,  Marcel Koenig ,  Erich Kreiselmaier

IPC分类号： F01D5/30 ,  B23P6/00

CPC分类号： F01D9/02 ,  F01D5/005 ,  F05D2240/80

摘要： The guide vane of a gas turbine comprises a blade having an outer platform connectable to a guide vane carrier or gas turbine casing, and at the opposite end an inner platform that carries a cover plate. The inner platform has a dovetail housing to which the cover plate is connected. The method for replacing the cover plate consists in separating the cover plate from the inner platform by cutting along the profile of the dovetail housing, then making the cover plate to slide out of the dovetail housing, thus inserting a new or refurbished cover plate into the dovetail housing.

摘要翻译： 燃气轮机的引导叶片包括具有可连接到导向叶片承载件或燃气轮机壳体的外部平台的叶片，并且在相对端具有承载盖板的内部平台。 内平台具有连接盖板的燕尾形外壳。 更换盖板的方法在于通过沿着燕尾形外壳的轮廓切割将盖板与内平台分开，然后使盖板从燕尾壳体滑出，从而将新的或翻新的盖板插入 燕尾屋

公开(公告)号：US20090033036A1

公开(公告)日：2009-02-05

申请号：US12189976

申请日：2008-08-12

申请人： Peter Marx ,  James Robert Wise ,  Marcel Koenig

发明人： Peter Marx ,  James Robert Wise ,  Marcel Koenig

IPC分类号： F01D11/00

CPC分类号： F01D11/005 ,  F01D11/00 ,  F05D2240/57 ,  F05D2250/70 ,  F16J15/0887

摘要： A gas turbine includes a supporting structure which concentrically surrounds a hot gas path and is shielded with respect to the hot gas path by an annular heat shield (15′), which heat shield (15′) includes a multiplicity of segments which are arranged one behind the other in a circumferential direction and which in each case butt against one another in the circumferential direction so as to form a gap, seals (16′), being arranged for sealing off the gaps between the segments butting against one another, the seals having thin elongate sealing strips (23), which are accommodated in corresponding sealing slots (19), delimited transversely with respect to the longitudinal direction by a wall (25), in the mutually opposite end faces of the segments of the heat shield (15′) which butt against one another. Vibrationally-induced rubbing through of the wall is inhibited or prevented by the frictional surface between the wall (25) and the sealing strips (23) being markedly enlarged with respect to the end face (22) of the sealing strip (23).

摘要翻译： 一种燃气轮机包括一个支撑结构，该支撑结构同心地围绕热气体路径，并通过一个环形隔热罩（15'）相对于热气路径进行屏蔽，该隔热罩（15'）包含多个段， 在圆周方向上彼此相对并且在每个情况下在圆周方向上彼此对接以形成间隙，密封件（16'）被设置用于密封彼此对接的部分之间的间隙，密封件 具有细长的密封条（23），其被容纳在相应的密封槽（19）中，在隔热件（15）的段的相互相对的端面中通过壁（25）横向相对于纵向方向限定 '）彼此对接。 通过壁（25）和密封条（23）之间的摩擦表面相对于密封条（23）的端面（22）显着地增大，可以抑制或阻止振动引起的壁的摩擦。

公开(公告)号：US07122548B2

公开(公告)日：2006-10-17

申请号：US10874743

申请日：2004-06-24

申请人： Fang-Jie Zhang ,  Tomas Vojkovsky ,  Ping Huang ,  Congxin Liang ,  Steven Huy Do ,  Marcel Koenig ,  Jingrong Cui

发明人： Fang-Jie Zhang ,  Tomas Vojkovsky ,  Ping Huang ,  Congxin Liang ,  Steven Huy Do ,  Marcel Koenig ,  Jingrong Cui

IPC分类号： C07D487/04 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of the Formula (I), and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症

公开(公告)号：US20050014755A1

公开(公告)日：2005-01-20

申请号：US10878632

申请日：2004-06-29

申请人： Tomas Vojkovsky ,  Marcel Koenig ,  Fang-Jie Zhang ,  Jingrong Cui

发明人： Tomas Vojkovsky ,  Marcel Koenig ,  Fang-Jie Zhang ,  Jingrong Cui

IPC分类号： A61K20060101 ,  A61K31/407 ,  A61K31/53 ,  A61P35/00 ,  C07D487/12 ,  C07D487/14

CPC分类号： C07D487/14

摘要： The present invention relates to compounds of the Formulae (I) and (II), wherein R1—R10 and G are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

摘要翻译： 本发明涉及式（I）和（II）的化合物，其中R1-R10和G如本文所定义，及其药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

公开(公告)号：US20120309757A1

公开(公告)日：2012-12-06

申请号：US13490324

申请日：2012-06-06

申请人： Theodore Mark Kamenecka ,  Patrick R. Griffin ,  Marcel Koenig ,  Alice Asteian ,  Anne-Laure Blayo ,  Yuanjun He ,  Youseung Shin

发明人： Theodore Mark Kamenecka ,  Patrick R. Griffin ,  Marcel Koenig ,  Alice Asteian ,  Anne-Laure Blayo ,  Yuanjun He ,  Youseung Shin

IPC分类号： A61K31/404 ,  C07D403/10 ,  C07D401/10 ,  A61K31/4439 ,  C07D405/12 ,  C07D413/12 ,  A61K31/5377 ,  C07D401/12 ,  A61K31/4709 ,  A61K31/454 ,  C07D413/10 ,  A61K31/4245 ,  A61P3/10 ,  A61P3/04 ,  A61P29/00 ,  C07D209/12

CPC分类号： C07D209/42 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D493/04

摘要： The invention provides molecular entities that bind with high affinity to PPARG (PPARγ), inhibit kinase-mediated, e.g., cdk5-mediated, phosphorylation of PPARG, but do not exert an agonistic effect on PPARG. Compounds of the invention can be used for treatment of conditions in patients wherein PPARG plays a role, such as diabetes, insulin resistance, impaired glucose tolerance, pre-diabetes, hyperglycemia, hyperinsulinemia, obesity, or inflammation. In methods of treatment of these conditions using a compound of the invention, the compound can avoid producing side effects of significant weight gain, edema, impairment of bone growth or formation, or cardiac hypertrophy, or any combination thereof, in the patient receiving the compound. Methods of preparation of the compounds, bioassay methods for evaluating compounds of the invention as non-agonistic PPARG binding compounds, and pharmaceutical compositions are also provided.

摘要翻译： 本发明提供了以高亲和力结合PPARG（PPARγ），抑制激酶介导的，例如cdk5介导的PPARG磷酸化，但不对PPARG发挥激动作用的分子实体。 本发明的化合物可用于治疗其中PPARG起作用的患者中的病症，例如糖尿病，胰岛素抵抗，葡萄糖耐量降低，前期糖尿病，高血糖症，高胰岛素血症，肥胖症或炎症。 在使用本发明化合物治疗这些病症的方法中，化合物可以避免在接受化合物的患者中产生显着的体重增加，水肿，骨生长或形成的损害或心脏肥大或其任何组合的副作用 。 还提供了制备化合物的方法，用于评价本发明的化合物作为非激动性PPARG结合化合物的生物测定方法和药物组合物。

公开(公告)号：US07147684B2

公开(公告)日：2006-12-12

申请号：US10829378

申请日：2004-04-22

申请人： Gordon Anderson ,  Marcel Koenig

发明人： Gordon Anderson ,  Marcel Koenig

IPC分类号： B01D45/06

CPC分类号： F02C7/052 ,  B01D45/02 ,  B01D45/08 ,  F01D25/32 ,  F05D2260/607 ,  Y10S55/14

摘要： For preparing a gas stream cleaned from dust and dirt particles, a device is proposed in which an outflow channel (2) for cleaned medium has at its mouth in an inflow channel (1) an extension element (4), which projects into the inflow channel. A cover element (6) covers an end inflow aperture (4a) of the extension element. In an embodiment of the invention, the extension element (4) has lateral inlet apertures (5). The cover element (6) is preferably constituted hood-shaped, and has axial extension elements (6a), which at least partially cover the extension element (4) in the axial direction, and advantageously extend over the lateral inlet apertures. The stream entering the outflow channel (2) for cleaned medium must overcome strong flow deflections, so that particles with a low flow following ability cannot get into this channel. Further outflow channels (3) for conducting the remaining dust-laden medium are arranged substantially flush with the wall (7) of the inflow channel.

摘要翻译： 为了制备从灰尘和污垢颗粒清洁的气流，提出了一种装置，其中用于清洁介质的流出通道（2）在其流入通道（1）的口处具有延伸元件（4），其延伸到流入 渠道。 盖元件（6）覆盖延伸元件的端部流入孔（4a）。 在本发明的一个实施例中，延伸元件（4）具有侧向入口孔（5）。 盖元件（6）优选地构成罩形，并且具有轴向延伸元件（6a），其在轴向方向上至少部分地覆盖延伸元件（4），并且有利地在横向入口孔上延伸。 进入清洗介质的流出通道（2）的料流必须克服强大的流动偏差，使流动跟随能力低的颗粒不能进入该通道。 用于引导剩余的含尘介质的另外的流出通道（3）被布置成与流入通道的壁（7）大致平齐。

公开(公告)号：US20060009493A1

公开(公告)日：2006-01-12

申请号：US10875508

申请日：2004-06-25

申请人： Marcel Koenig ,  Jingrong Cui ,  Chung Wei ,  Steven Do ,  Fang-Jie Zhang ,  Tomas Vojkovsky ,  John Ramphal ,  Guang Yang ,  Matthew Mattson ,  Christopher Nelson ,  Peng Tang

发明人： Marcel Koenig ,  Jingrong Cui ,  Chung Wei ,  Steven Do ,  Fang-Jie Zhang ,  Tomas Vojkovsky ,  John Ramphal ,  Guang Yang ,  Matthew Mattson ,  Christopher Nelson ,  Peng Tang

IPC分类号： C07D43/02 ,  A61K31/4439

CPC分类号： C07D209/40 ,  C07D209/34 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

摘要： The present invention relates to compounds of the formulae (I)-(XII), wherein R1-R71, A, B, X, Y, G, L and Z are defined herein, and their pharmaceutically acceptable salts. These compounds modulate the activity of c-Met and are therefore expected to be useful in the prevention and treatment of c-Met related disorders such as cancer.

摘要翻译： 本发明涉及式（I） - （XII）的化合物，其中R 1 -R 71，A，B，X，Y，G，L和 Z在本文中定义，及其药学上可接受的盐。 这些化合物调节c-Met的活性，因此预期可用于预防和治疗c-Met相关疾病如癌症。

公开(公告)号：US06797725B2

公开(公告)日：2004-09-28

申请号：US10118321

申请日：2002-04-09

申请人： Connie Li Sun ,  Chung Chen Wei ,  Peng Cho Tang ,  Marcel Koenig ,  Yong Zhou ,  Tomas Vojkovsky ,  Asaad S. Nematalla

发明人： Connie Li Sun ,  Chung Chen Wei ,  Peng Cho Tang ,  Marcel Koenig ,  Yong Zhou ,  Tomas Vojkovsky ,  Asaad S. Nematalla

IPC分类号： A61K31403

CPC分类号： C07D403/06 ,  C07D403/14 ,  C07F9/5728 ,  C07F9/65583 ,  C07H15/26

摘要： The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

摘要翻译： 本发明涉及吡咯取代的2-二氢吲哚酮化合物及其药学上可接受的盐，其调节蛋白激酶的活性，因此预期可用于预防和治疗与蛋白激酶相关的细胞病症例如癌症。

公开(公告)号：US06596772B1

公开(公告)日：2003-07-22

申请号：US09645879

申请日：2000-08-25

申请人： Ping Huang ,  Chung Chen Wei ,  Peng Cho Tang ,  Chris Liang ,  John Ramphal ,  Bahija Jallal ,  John Biltz ,  Sharon Li ,  Matt Mattson ,  Gerald McMahon ,  Marcel Koenig

发明人： Ping Huang ,  Chung Chen Wei ,  Peng Cho Tang ,  Chris Liang ,  John Ramphal ,  Bahija Jallal ,  John Biltz ,  Sharon Li ,  Matt Mattson ,  Gerald McMahon ,  Marcel Koenig

IPC分类号： A61K3105

CPC分类号： C07C311/09 ,  C07C317/14 ,  C07C317/22 ,  C07C317/32 ,  C07C317/40 ,  C07C317/44 ,  C07C317/50 ,  C07C323/65 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D209/42 ,  C07D231/24 ,  C07D235/16 ,  C07D235/18 ,  C07D295/096

摘要： The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.

摘要翻译： 本发明涉及三氟甲磺酰基和三氟甲磺酰氨基化合物及其生理上可接受的盐及其前药。 预期这些化合物可调节与细胞信号转导相关的蛋白质酪氨酸酶的活性，特别是蛋白酪氨酸磷酸酶，因此预期可用于预防和治疗与异常蛋白酪氨酸酶相关的细胞信号相关的病症 转导，如癌症，糖尿病，免疫调节，神经退行性疾病，骨质疏松症和感染性疾病。 本发明还涉及含有氟甲基磺酰基的化合物作为磷酸酯模拟物的用途。 这些模拟物可用于抑制，调节或调节细胞中磷酸结合蛋白的活性。