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1.发明授权公开(公告)号：US08609117B2
公开(公告)日：2013-12-17
申请号：US12728580
申请日：2010-03-22
IPC分类号： A61K31/557
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1是选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; -R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个选自-OR“，-OCOR”，“ -SR“'，-SCOR”，NR“'R”'， - NHCOR''，卤素，-CN，-COOR“和-COR”'，其中R“ 和R“'可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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2.发明授权Compositions comprising jasmonic acid derivatives and use of these derivatives 有权包含茉莉酸衍生物的组合物和这些衍生物的用途公开(公告)号：US08481594B2
公开(公告)日：2013-07-09
申请号：US12406570
申请日：2009-03-18
IPC分类号： A61K31/122 , A61K31/60
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein;R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein;as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1为选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R 2选自包含1至18个碳原子的饱和和不饱和的，直链的，支链的和环状的烃基，其任选被1-5个相同或不同的选自-OR“，-OCOR” - ， - ，“NR”，“R”“，”-NHCOR“，卤素，-CN，-COOR”和-COR“，其中R”'和R“ 其可以相同或不同，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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3.发明申请COMPOSITIONS COMPRISING JASMONIC ACID DERIVATIVES AND USE OF THESE DERIVATIVES 有权包含苹果酸衍生物的组合物和这些衍生物的使用公开(公告)号：US20100069497A1
公开(公告)日：2010-03-18
申请号：US12406570
申请日：2009-03-18
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: —R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; —R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：-R1是选自-COOR'，-CONR'R“，-CHOOR'， - COR'， - CH 2 R'， - SO 2 OR '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; -R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个相同或不同的选自-OR'，-OCOR'“，-SR '“，-SCOR'”，NR“R”“，-NHCOR'”，卤素，-CN，-COOR'和-COR'“，其中R'”和R“”可以相同或不同 ，在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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4.发明授权Compositions comprising jasmonic acid derivatives and use of these derivatives 有权包含茉莉酸衍生物的组合物和这些衍生物的用途公开(公告)号：US08603502B2
公开(公告)日：2013-12-10
申请号：US10356551
申请日：2003-02-03
IPC分类号： A61K31/557
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein, as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1为选自-COOR'，-CONR'R“，-CHOOR'，-COR'，-CH2R'，-SO2OR的基团 '，-PO 3 R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R 2选自包含1至18个碳原子的饱和和不饱和的，直链的，支链的和环状的烃基，其任选被1-5个相同或不同的选自-OR“，-OCOR” - ， - SR“'，-SCOR''，NR”'R“'， - NHCOR''，卤素，-CN，-COOR”和-COR“，其中R”'和 R“”可以相同或不同，并且这些化合物的用途，例如促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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5.发明申请COMPOSITIONS COMPRISING JASMONIC ACID DERIVATIVES AND USE OF THESE DERIVATIVES 有权包含苹果酸衍生物的组合物和这些衍生物的使用公开(公告)号：US20100179222A1
公开(公告)日：2010-07-15
申请号：US12728580
申请日：2010-03-22
CPC分类号： C07C69/732 , A61K8/345 , A61K8/365 , A61K8/44 , A61Q1/02 , A61Q5/00 , A61Q19/00 , A61Q19/08 , C07C35/06 , C07C59/11 , C07C59/46 , C07C69/675 , C07C2601/08
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: wherein: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R″, which may be identical or different, are defined herein; R2 is chosen from saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are defined herein; as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R1是选自-COOR'，-CONR'R“，-CHOOR'，-COR'， - CH 2 R'， - SO 2 OR' ，-PO3R'R“和-NHR'，其中R'和R”可以相同或不同，在本文中定义; R2选自包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其任选被1至5个选自-OR'，-OCOR'“，-SR'的相同或不同的实体取代， “，-SCOR'”，NR“R”“，-NHCOR”，卤素，-CN，-COOR'和-COR'“，其中R'”和R“”可以相同或不同， 在本文中定义; 以及这些化合物的使用，例如，促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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公开(公告)号：US20060167102A1
公开(公告)日：2006-07-27
申请号：US11389166
申请日：2006-03-27
申请人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
发明人： Jean-Luc Leveque , Maria Dalko , Christophe Boulle
IPC分类号： A61K31/557
摘要： Cosmetic or pharmaceutical compositions comprising compounds of formula (I) and the corresponding salts thereof: in which: R1 is a radical chosen from —COOR′, —CONR′R″, —CH2OR′, —COR′, —CH2R′, —SO2OR′, —PO3R′R″ and —NHR′, wherein R′ and R,″ which may be identical or different, are chosen from a hydrogen atom and saturated and unsaturated, linear, branched and cyclic hydrocarbon radicals comprising from 1 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms; R2 is a radical chosen from linear, branched and cyclic hydrocarbon radicals comprising at least one unsaturation and comprising from 2 to 18 carbon atoms, which are optionally substituted by from 1 to 5 identical or different entities chosen from —OR′″, —OCOR′″, —SR′″, —SCOR′″, NR′″R″″, —NHCOR′″, halogen atoms, —CN, —COOR′″ and —COR′″, wherein R′″ and R″″, which may be identical or different, are chosen from a hydrogen atom, aryl radicals and saturated and unsaturated, linear and branched hydrocarbon radicals comprising from 1 to 4 carbon atoms as well as the use of these compounds, for example, to promote skin desquamation, to stimulate epidermal renewal and/or to combat the signs of skin ageing.
摘要翻译： 包含式（I）化合物及其相应盐的化妆品或药物组合物：其中：R 1是选自-COOR'，-CONR'R“，-CH” 2 OR'，-COR'，-CH 2 R'，-SO 2 OR'，-PO 3 R' R“和-NHR'，其中可以相同或不同的R'和R”选自氢原子和包含1至18个碳原子的饱和和不饱和，直链，支链和环状烃基，其中 任选地被1至5个相同或不同的选自-OR“，-OCOR”'，-SR“'，-SCOR”，NR“'R”'，-NHCOR “，卤素原子，-CN，-COOR”和-COR“，其中R”'和R“'可以相同或不同，选自氢原子，芳基 和包含1至4个碳原子的饱和和不饱和的直链和支链烃基; R 2是选自包含至少一个不饱和键并包含2至18个碳原子的直链，支链和环状烃基的基团，其任选被1至5个相同或不同的实体取代，所述实体选自 -OR''，-OCOR''，-SR“'，-SCOR''，NR”'R“'， - NHCOR''，卤素原子，-CN，-COOR” '和-COR''，其中可以相同或不同的R“'和R”'选自氢原子，芳基和饱和和不饱和的直链和支链烃基，其包含1至 4个碳原子以及这些化合物的使用，例如促进皮肤脱屑，刺激表皮更新和/或抵抗皮肤老化的迹象。
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公开(公告)号：US08351041B2
公开(公告)日：2013-01-08
申请号：US11666912
申请日：2005-11-28
申请人： Jean-Luc Leveque , Neso Sojic
发明人： Jean-Luc Leveque , Neso Sojic
IPC分类号： G01N21/55
CPC分类号： A61B5/441 , A61B5/0059 , A61B5/0071
摘要： The present invention relates to a method of observing biological tissue, the method comprising: collecting through a first end of a bundle of optical fibers light from a surface of the tissue; observing at least one image of the tissue at a second end of the bundle, while injecting light into the second end of the bundle to illuminate the surface of the tissue.
摘要翻译： 本发明涉及一种观察生物组织的方法，所述方法包括：通过光纤束的第一端收集来自组织表面的光; 在束的第二端观察组织的至少一个图像，同时将光注入束的第二端以照亮组织的表面。
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公开(公告)号：US08026911B2
公开(公告)日：2011-09-27
申请号：US11723307
申请日：2007-03-19
IPC分类号： G06T15/00
CPC分类号： G06T11/203 , G06T17/00 , G06T19/20
摘要： The invention relates to a method of generating a synthesized image of a hair, comprising the following steps: calculating the shape of the hair by applying a behavioral relationship determining the shape of the hair as a function of a physical parameter linked to a mechanical property of the hair, in particular the linear density; producing an image of the hair of shape that has been calculated in this way. The behavioral relationship may be given by the minimization of the following function: E = K L ∫ 0 1 [ 1 2 ( k ~ ( s ~ ) - α ) 2 + 1 β z ~ ( s ~ ) ] ⅆ s ~ , where α=Lk0 and β=K/gμL3, and where L designates the length of the hair, k0 its spontaneous curvature, K its bending moment, μ its linear density and g the acceleration due to gravity, {tilde over (s)} the curvilinear abscissa relative to the length of the hair, {tilde over (k)} its local curvature relative to its length and {tilde over (z)} its height relative to its length.
摘要翻译： 本发明涉及一种产生头发合成图像的方法，包括以下步骤：通过应用确定头发形状的行为关系来计算头发的形状，作为与机械特性相关联的物理参数的函数 头发，特别是线密度; 产生以这种方式计算的形状的头发的图像。 行为关系可以通过以下函数的最小化来给出：E = K L？0 1 [1 2（k〜（s〜） - α）2 + 1＆bgr; z〜（s〜）]ⅆs〜，其中α= Lk0和＆bgr; = K /gμL3，其中L表示头发长度，k0表示自发曲率，K表示其弯曲力矩，μ为线性密度 并且g由于重力引起的加速度，相对于头发长度的曲线横坐标（相当于（k）}），其相对于其长度的局部曲率和（z）上的波形）的高度 相对于其长度。
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公开(公告)号：US5944667A
公开(公告)日：1999-08-31
申请号：US930577
申请日：1998-01-16
申请人： Jean-Luc Leveque , Pierre Corcuff , Jean Mignot
发明人： Jean-Luc Leveque , Pierre Corcuff , Jean Mignot
CPC分类号： A61B5/442
摘要： A device for evaluating the creasing of the skin in vivo. A zone of the skin to be examined is creased. The zone of the creased skin is scanned with an incident luminous beam which is emitted by a light source. The light reflected by the creased skin is detected. The detected light is converted into an electrical signal. At least one parameter representing the profile of the creased skin is extracted from the electrical signal. This device makes it possible to evaluate the mechanical properties of the dermis, such as its elasticity and firmness and the aging of the skin, as well as to evaluate the effectiveness of products intended to counteract such aging.
摘要翻译： PCT No.PCT / FR97 / 00278 Sec。 371日期1998年1月16日 102（e）日期1998年1月16日PCT提交1997年2月13日PCT公布。 出版物WO97 / 29686 日期1997年8月21日用于评估体内皮肤皱纹的装置。 要检查的皮肤区域有皱纹。 用光源发射的入射光束扫描皱褶皮肤的区域。 检测由皱褶皮肤反射的光。 检测到的光被转换成电信号。 从电信号中提取表示折痕皮肤的轮廓的至少一个参数。 该装置可以评估真皮的机械性能，例如其弹性，坚固度和皮肤老化，以及评估旨在抵抗这种老化的产品的有效性。
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10.发明授权Apparatus for in vivo observation of the microscopic structure of the skin or of a similar tissue 失效用于体内观察皮肤或类似组织的微观结构的装置
公开(公告)号：US5719700A
公开(公告)日：1998-02-17
申请号：US791932
申请日：1997-01-31
申请人： Pierre Corcuff , Jean-Luc Leveque
发明人： Pierre Corcuff , Jean-Luc Leveque
CPC分类号： G02B21/006 , A61B5/0068 , A61B5/441 , A61B5/6833 , A61B5/6835 , G02B21/0028 , A61B2562/0242 , A61B2562/146
摘要： A confocal microscope equipped with a light source, a rotary disk having holes, a highly sensitive image receiver or camera, an immersion lens, and a contact endpiece for contacting the skin and in which is engaged at least a lower part of the lens. The endpiece includes a central opening and abuts the skin about the central opening. The microscope allows for relative axial displacement of the contact endpiece relative to the lens.
摘要翻译： 配备有光源的共焦显微镜，具有孔的旋转盘，高灵敏度图像接收器或照相机，浸没透镜和用于接触皮肤并且与至少下部透镜接合的接触端头。 端片包括中央开口并且围绕中心开口邻接皮肤。 显微镜允许接触端片相对于透镜的相对轴向位移。
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