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    Single variable domains against notch pathway members
    8.
    发明授权
    Single variable domains against notch pathway members 有权
    针对切口通路部件的单个可变结构域

    公开(公告)号：US08557965B2

    公开(公告)日：2013-10-15

    申请号：US12934766

    申请日：2009-04-07

    申请人： Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Edward Dolk ,  Renee De Bruin ,  Peter Vanlandschoot

    发明人： Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Edward Dolk ,  Renee De Bruin ,  Peter Vanlandschoot

    IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K14/475 ,  C07K14/705

    CPC分类号： C07K16/28 ,  C07K16/2896 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/76

    摘要： The present invention relates to amino acid sequences (also referred to herein as “single variable domain(s) of the invention”. “Nanobody™ of the invention” or “Nanobodies™ of the invention”, ilpolypeptide(s) of the invention”) that are directed against (as defined herein) members of the Notch signalling pathway such as the four mammalian members of the Notch Receptors (Notch-1, Notch-2, Notch-3, Notch-4, hereinafter also “Notch Receptors”) and the five mammalian members of the Notch Ligands (the Delta-like family with “DLL1”, “DLL3”, “DLL4” wherein “DLL” stands for Delta-like ligand; the Jagged family with “Jagged-1”, “Jagged-2”, hereinafter also “Notch Ligands”), as well as to constructs that comprise or essentially consist of one or more such single variable domain(s) (also referred to herein as “construct of the invention” and “constructs of the invention”, “Nanobody™ of the invention” or “Nanobodies™ of the invention”, respectively). In particular, this invention relates to Notch pathway interfering single variable domains down- or up-regulating Notch signaling (also referred to herein “Notch-antagonists” or “Notch-agonists”).

    摘要翻译： 本发明涉及本发明的“纳米抗体（TM）”或“本发明的纳米抗体（TM）”的多肽， （Notch-1，Notch-2，Notch-3，Notch-4，以下也称为“Notch-1”）的四种哺乳动物成员 Notch受体“）和Notch Ligands的五个哺乳动物成员（具有”DLL1“，”DLL3“，”DLL4“的Delta样家族，其中”DLL“代表三角形配体;具有”Jagged-1“ “，”Jagged-2“，以下也称为”Notch Ligands“），以及包含或基本上由一个或多个这样的单可变结构域（本文中也称为”本发明的构建体“）和 本发明的“构建体”，“本发明的纳米抗体TM”或“本发明的纳米抗体”），特别地，本发明相关 es到Notch途径干扰单可变区下调或上调Notch信号传导（本文也称为“Notch-拮抗剂”或“Notch-agonists”）。