公开(公告)号：US09005963B2

公开(公告)日：2015-04-14

申请号：US13124001

申请日：2009-10-14

申请人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Dominique Schols ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot ,  Peter Verheesen

发明人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Dominique Schols ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot ,  Peter Verheesen

IPC分类号： C07K16/00 ,  C07K16/18 ,  C07K16/28 ,  C07H21/04 ,  C12N5/07 ,  C12N5/10 ,  C12N5/16 ,  C12N5/22 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K16/2866 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/2812 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/31 ,  Y10S530/866

摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. NANOBODIES specifically recognizing hCD4, hCXCR4, hCCR5, hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-BI, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.

摘要翻译： 本发明涉及针对（如本文定义的）病毒和/或细菌的人细胞受体的氨基酸序列，例如， NANOBODIES专门识别hCD4，hCXCR4，hCCR5，hTLR4，人αV整联蛋白，人β3整联蛋白，人β1整联蛋白，人α2整联蛋白，hCD81，hSR-BI，hClaudin-1，hClaudin-6和hClaudin-9，以及化合物 或构建体，特别是蛋白质和多肽，其包含或基本上由一个或多个这样的氨基酸序列组成。 氨基酸序列可用于预防HIV，HCV，腺病毒，汉坦病毒，疱疹病毒，回波病毒1等的人细胞进入。

公开(公告)号：US09212226B2

公开(公告)日：2015-12-15

申请号：US12992982

申请日：2009-05-18

申请人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot

发明人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) G-protein coupled receptors (GPCRs) and in particular to CXCR4 and CXCR7, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). Furthermore, the invention provides a new method of making amino acid sequences that are directed against transmembrane protein, and in particular for multiple spanning transmembrane proteins for which the native conformation cannot be reproduced in other “in vitro” system (e.g. GPCRs in general).

摘要翻译： 本发明涉及针对（如本文定义的）G-蛋白偶联受体（GPCR），特别是涉及CXCR4和CXCR7的氨基酸序列，以及组成或组合的化合物或构建体，特别是蛋白质和多肽 或基本上由一个或多个这样的氨基酸序列（本文中也分别称为本发明的氨基酸序列，本发明的化合物）和“本发明的多肽”）基本上组成。 此外，本发明提供了一种制备针对跨膜蛋白的氨基酸序列的新方法，特别是针对在其它“体外”系统（例如一般的GPCR）中天然构象不能再现的多跨跨膜蛋白的新方法。

公开(公告)号：US20110206660A1

公开(公告)日：2011-08-25

申请号：US12992982

申请日：2009-05-18

申请人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnicken ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot

发明人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnicken ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Peter Vanlandschoot

IPC分类号： A61K39/395 ,  C12N5/10 ,  C12N1/00 ,  C07K16/28 ,  C40B30/04 ,  C07K16/46 ,  C07H21/00 ,  A61P35/00 ,  A61P37/04

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) G-protein coupled receptors (GPCRs) and in particular to CXCR4 and CXCR7, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). Furthermore, the invention provides a new method of making amino acid sequences that are directed against transmembrane protein, and in particular for multiple spanning transmembrane proteins for which the native conformation cannot be reproduced in other “in vitro” system (e.g. GPCRs in general).

摘要翻译： 本发明涉及针对（如本文定义的）G-蛋白偶联受体（GPCR），特别是涉及CXCR4和CXCR7的氨基酸序列，以及组成或组合的化合物或构建体，特别是蛋白质和多肽 或基本上由一个或多个这样的氨基酸序列（本文中也分别称为本发明的氨基酸序列，本发明的化合物）和“本发明的多肽”）基本上组成。 此外，本发明提供了一种制备针对跨膜蛋白的氨基酸序列的新方法，特别是针对在其它“体外”系统（例如一般的GPCR）中天然构象不能再现的多跨跨膜蛋白的新方法。

公开(公告)号：US20110318347A1

公开(公告)日：2011-12-29

申请号：US13124001

申请日：2009-10-14

申请人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Dominique Schols ,  Michael John Scott Saunders ,  Johannes Josephn Wilhelmus De Haard ,  Peter Vanlandschoot ,  Peter Verheesen

发明人： Christophe Blanchetot ,  Martine Smit ,  Regorius Leurs ,  Sven Jähnichen ,  Dominique Schols ,  Michael John Scott Saunders ,  Johannes Josephn Wilhelmus De Haard ,  Peter Vanlandschoot ,  Peter Verheesen

IPC分类号： A61K39/395 ,  C07H21/00 ,  C12N5/10 ,  C07K16/18 ,  A61P31/12 ,  C12N1/15 ,  C12N1/19 ,  C40B30/04 ,  A61P31/04 ,  C07K16/28 ,  C12N1/21

CPC分类号： C07K16/2866 ,  A61K39/39533 ,  A61K2039/505 ,  C07K16/2812 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/31 ,  Y10S530/866

摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) human cellular receptors for viruses and/or bacteria such as e.g. Nanobodies specifically recognizing hCD4, hCXCR4, hCCR5. hTLR4, human alphaV integrin, human beta3 integrin, human beta1 integrin, human alpha2 integrin, hCD81, hSR-B1, hClaudin-1, hClaudin-6 and hClaudin-9, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. Said amino acid sequences may be used to prevent human cell entry of HIV, HCV, adenoviruses, hantavirus, herpesvirus, echo-virus 1 and others.

摘要翻译： 本发明涉及针对（如本文定义的）病毒和/或细菌的人细胞受体的氨基酸序列，例如， 纳米抗体专门识别hCD4，hCXCR4，hCCR5。 hTLR4，人αV整联蛋白，人β3整联蛋白，人β1整联蛋白，人α2整联蛋白，hCD81，hSR-B1，hClaudin-1，hClaudin-6和hClaudin-9，以及化合物或构建体，特别是蛋白质和多肽 ，其包含或基本上由一个或多个这样的氨基酸序列组成。 所述氨基酸序列可用于预防HIV，HCV，腺病毒，汉坦病毒，疱疹病毒，回波病毒1等的人细胞进入。

公开(公告)号：US20110294982A1

公开(公告)日：2011-12-01

申请号：US12991576

申请日：2009-05-11

申请人： Peter Vanlandschoot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Christophe Blanchetot ,  Theo Verrips ,  Marc Antoine Gijsbert Gilles Vooijs ,  Adrianus Johannes Groot ,  Mohamed El Khattabi

发明人： Peter Vanlandschoot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard ,  Christophe Blanchetot ,  Theo Verrips ,  Marc Antoine Gijsbert Gilles Vooijs ,  Adrianus Johannes Groot ,  Mohamed El Khattabi

IPC分类号： C07K14/00

CPC分类号： C07K16/2839 ,  C07K16/2842 ,  C07K16/2845 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76

摘要： The present invention relates to amino acid sequences that are directed against (as defined herein) Integrins, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences (also referred to herein as □amino acid sequences of the invention□ com□pounds of the invention□, poly□peptides of the invention□, respectively).

摘要翻译： 本发明涉及针对（如本文所定义的）整联蛋白以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列（也称为 本发明的□氨基酸序列□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□

公开(公告)号：US09156914B2

公开(公告)日：2015-10-13

申请号：US12520218

申请日：2007-12-19

申请人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

发明人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

IPC分类号： C07K16/00 ,  C07K16/46 ,  C07K16/40 ,  A61K39/00

CPC分类号： C07K16/40 ,  A61K39/00 ,  C07K2317/22 ,  C07K2317/569 ,  C07K2317/75 ,  C07K2317/76

摘要： The present application relates to amino acid sequences that are directed against and/or that can specifically bind to metalloproteinases from the ADAM family, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences, and to methods of preparing the same.

摘要翻译： 本申请涉及针对和/或可以特异性结合来自ADAM家族的金属蛋白酶的氨基酸序列，以及包含或基本上由一个或多个组成的化合物或构建体，特别是蛋白质和多肽的氨基酸序列 这样的氨基酸序列，以及其制备方法。

公开(公告)号：US08906680B2

公开(公告)日：2014-12-09

申请号：US12520208

申请日：2007-12-21

申请人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

发明人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

IPC分类号： C12N5/07 ,  C12P21/04 ,  C07H21/04 ,  C07K16/00 ,  C07K16/24

CPC分类号： C07K16/24 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to amino acid sequences that are directed against chemokines, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

摘要翻译： 本发明涉及针对趋化因子的氨基酸序列，以及包含或基本由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

公开(公告)号：US20100092460A1

公开(公告)日：2010-04-15

申请号：US12520208

申请日：2007-12-21

申请人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

发明人： Christophe Blanchetot ,  Michael John Scott Saunders ,  Johannes Joseph Wilhelmus De Haard

IPC分类号： A61K39/395 ,  C07K16/00 ,  C07H21/04 ,  C12N5/071 ,  C12P21/00 ,  A61P37/06

CPC分类号： C07K16/24 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to amino acid sequences that are directed against chemokines, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.

摘要翻译： 本发明涉及针对趋化因子的氨基酸序列，以及包含或基本上由一个或多个这样的氨基酸序列组成的化合物或构建体，特别是蛋白质和多肽。 本发明还涉及编码这种氨基酸序列和多肽的核酸; 涉及制备这种氨基酸序列和多肽的方法; 宿主表达或能够表达这种氨基酸序列或多肽的细胞; 包括这样的氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的。

公开(公告)号：US20120264917A1

公开(公告)日：2012-10-18

申请号：US13321979

申请日：2010-05-27

申请人： Michael John Scott Saunders ,  Christophe Blanchetot ,  Carlo Boutton ,  Heidi Rommelaere ,  Johannes Joseph Wilhelmus De Haard ,  Veronique De Brabandere ,  Marc Jozef Lauwereys ,  Erika Morizzo ,  Ann Union ,  Gert Verheyden

发明人： Michael John Scott Saunders ,  Christophe Blanchetot ,  Carlo Boutton ,  Heidi Rommelaere ,  Johannes Joseph Wilhelmus De Haard ,  Veronique De Brabandere ,  Marc Jozef Lauwereys ,  Erika Morizzo ,  Ann Union ,  Gert Verheyden

IPC分类号： C07K16/46

CPC分类号： C07K16/244 ,  C07K2317/22 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/569

摘要： Biparatopic protein constructs that are directed against IL-23, and in particular against the p19 subunit of IL-23. The constructs comprise at least a first binding domain or binding unit directed against a first defined epitope on p19 and at least a second binding domain or binding unit directed against a second defined epitope on p19 (or the p19/p40 interface). The binding domains or binding units may in particular be a domain antibody, a single domain antibody, a dAb or a Nanobody®. The constructs and pharmaceutical compositions comprising the same can be used for the prevention and/or treatment of diseases and disorders associated with IL-23 or IL-23 mediated signaling, such as inflammation and inflammatory disorders such as colitis, Crohn's disease and IBD, infectious diseases, psoriasis, cancer, autoimmune diseases, sarcoidosis, transplant rejection, cystic Fibrosis, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, viral infection, and common variable immunodeficiency.

摘要翻译： 针对IL-23，特别是针对IL-23的p19亚基的双比较性蛋白质构建体。 所述构建体包含至少第一结合结构域或针对p19上的第一定义表位的结合单位，以及针对p19（或p19 / p40界面）上的第二定义表位的至少第二结合结构域或结合单位。 结合域或结合单位特别可以是结构域抗体，单结构域抗体，dAb或纳米抗体。 包含其的构建体和药物组合物可用于预防和/或治疗与IL-23或IL-23介导的信号传导相关的疾病和病症，例如炎症和炎症性疾病如结肠炎，克罗恩病和IBD，感染性 疾病，牛皮癣，癌症，自身免疫疾病，结节病，移植排斥，囊性纤维化，哮喘，慢性阻塞性肺病，类风湿性关节炎，病毒感染和常见的免疫缺陷。

公开(公告)号：US20110053865A1

公开(公告)日：2011-03-03

申请号：US12745052

申请日：2008-11-27

申请人： Michael John Scott Saunders ,  Christophe Blanchetot ,  Heidi Rommelaere ,  Jo Vercammen ,  Johannes Joseph Wilhelmus De Haard

发明人： Michael John Scott Saunders ,  Christophe Blanchetot ,  Heidi Rommelaere ,  Jo Vercammen ,  Johannes Joseph Wilhelmus De Haard

IPC分类号： A61K38/16 ,  C07K14/00 ,  C07H21/00 ,  A61P43/00

CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/3007 ,  C07K16/32 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/32 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention relates to amino acid sequences that are directed against (at defined herein) heterodimeric cytokines and/or their receptors, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consists of one or more such amino acid sequences ( also referred to herein as “amino acid sequences of the invention”, “compounds of the invention”, and “polypeptides of the invention”, respectively). The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides (also referred to herein as “nucleic acids of the invention” or “nucleotides sequences of the invention”); to methods for preparing such amino acid sequences and polypeptides; to hose cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that complete such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes mentioned herein.

摘要翻译： 本发明涉及针对（在本文定义的）异二聚体细胞因子和/或其受体以及包含或基本上由一种或多种这样的蛋白质和/或其组合的化合物或构建体，特别是蛋白质和多肽的氨基酸序列 氨基酸序列（本文中也分别称为“本发明的氨基酸序列”，“本发明的化合物”和“本发明的多肽”）。 本发明还涉及编码这种氨基酸序列和多肽（本文中也称为“本发明的核酸”或“本发明的核苷酸序列”）的核酸; 涉及制备这种氨基酸序列和多肽的方法; 软管表达或能够表达这种氨基酸序列或多肽的细胞; 涉及完成这种氨基酸序列，多肽，核酸和/或宿主细胞的组合物，特别是药物组合物; 以及这些氨基酸序列或多肽，核酸，宿主细胞和/或组合物的用途，特别是用于预防，治疗或诊断目的，例如本文提及的预防，治疗或诊断目的。