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    Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
    2.
    发明授权
    Methods of modifying feeding behavior using compounds with afinity for the human hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 失效
    用于人类下丘脑非典型神经肽Y /肽YY受体（Y5）的化合物改变进食行为的方法

    公开(公告)号：US06645774B1

    公开(公告)日：2003-11-11

    申请号：US09447907

    申请日：1999-11-23

    申请人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    发明人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    IPC分类号： G01N33566

    CPC分类号： A61K31/137 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70571 ,  C12Q1/6883

    摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

    摘要翻译： 本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。 这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。 一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变型Y5受体的DNA的非人类转基因动物。

    Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
    4.
    发明授权
    Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
    修饰进食行为的方法，可用于这些方法的化合物和编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA

    公开(公告)号：US06713265B1

    公开(公告)日：2004-03-30

    申请号：US09194895

    申请日：1999-09-27

    申请人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    发明人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    IPC分类号： G01N33566

    CPC分类号： G01N33/9406 ,  C07K14/70571 ,  G01N33/566 ,  G01N2500/10

    摘要： The invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has structure (I). In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

    摘要翻译： 本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。 这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。 一种这样的化合物具有结构（I）。 此外，本发明提供编码Y5受体，分离的Y5受体蛋白质的分离的核酸分子，包含编码Y5受体的分离的核酸分子的载体，包含该载体的细胞，针对Y5受体的抗体，有用的核酸探针 用于检测编码Y5受体的核酸，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变Y5受体的DNA的非人转基因动物。

    Methods of screening and preparing a composition using DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
    5.
    发明授权
    Methods of screening and preparing a composition using DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) 有权
    使用编码下丘脑非典型神经肽Y /肽YY受体（Y5）的DNA筛选和制备组合物的方法

    公开(公告)号：US06316203B1

    公开(公告)日：2001-11-13

    申请号：US09200673

    申请日：1998-11-25

    申请人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    发明人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    IPC分类号： G01N33566

    CPC分类号： G01N33/9406 ,  A01K2217/05 ,  A61K31/137 ,  A61K38/00 ,  C07K14/70571 ,  C12Q1/6883 ,  G01N2500/02

    摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds are selective agonists or antagonists or the Y5 receptor. One such compound has the structure: In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA a normal or a mutant Y5 receptor.

    摘要翻译： 本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。 这些方法包括施用化合物是选择性激动剂或拮抗剂或Y5受体。 一种这样的化合物具有以下结构：此外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含用于检测核酸的所述酸性探针的细胞 酸编码Y5受体，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达正常或突变Y5受体的非人类转基因动物。

    Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
    7.
    发明授权
    Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5 失效
    用于这种方法的进食行为化合物的修饰方法和编码下丘脑非典型神经肽Y /肽YY受体Y5的DNA

    公开(公告)号：US5989920A

    公开(公告)日：1999-11-23

    申请号：US668650

    申请日：1996-06-04

    申请人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    发明人： Christophe P. G. Gerald ,  Richard L. Weinshank ,  Mary W. Walker ,  Theresa Branchek

    IPC分类号： A61K31/00 ,  A61K31/33 ,  A61K31/675 ,  C12P21/00 ,  G01N33/566 ,  G01N33/567

    CPC分类号： A61K31/137 ,  C07K14/70571 ,  C12Q1/6883 ,  A01K2217/05 ,  A61K38/00

    摘要： This invention provides methods of modifying feeding behavior, including increasing or decreasing food consumption, e.g., in connection with treating obesity, bulimia or anorexia. These methods involve administration of compounds that are selective agonists or antagonists for the Y5 receptor. One such compound has the structure: ##STR1## In addition, this invention provides an isolated nucleic acid molecule encoding a Y5 receptor, an isolated Y5 receptor protein, vectors comprising an isolated nucleic acid molecule encoding a Y5 receptor, cells comprising such vectors, antibodies directed to the Y5 receptor, nucleic acid probes useful for detecting nucleic acid encoding Y5 receptors, antisense oligonucleotides complementary to any unique sequences of a nucleic acid molecule which encodes a Y5 receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant Y5 receptor.

    摘要翻译： 本发明提供了改变进食行为的方法，包括增加或减少食物消耗，例如与治疗肥胖，贪食症或厌食症有关的方法。 这些方法包括施用作为Y5受体的选择性激动剂或拮抗剂的化合物。 一种这样的化合物具有以下结构：另外，本发明提供编码Y5受体的分离的核酸分子，分离的Y5受体蛋白，包含编码Y5受体的分离的核酸分子的载体，包含这种载体的细胞，针对 Y5受体，用于检测编码Y5受体的核酸的核酸探针，与编码Y5受体的核酸分子的任何独特序列互补的反义寡核苷酸，以及表达编码正常或突变型Y5受体的DNA的非人类转基因动物。

    Method of preparing GALR2 receptors composition
    10.
    发明授权
    Method of preparing GALR2 receptors composition 失效
    制备GALR2受体组成的方法

    公开(公告)号：US07060449B2

    公开(公告)日：2006-06-13

    申请号：US10298992

    申请日：2002-11-18

    申请人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    发明人： Kelli E. Smith ,  Christophe P. G. Gerald ,  Richard L. Weinshank ,  David Linemeyer ,  Theresa Branchek ,  Carlos Forray

    IPC分类号： G01N33/53

    CPC分类号： C12P21/02 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/72

    摘要： This invention provides isolated nucleic acids encoding mammalian galanin receptors, isolated galanin receptor proteins, vectors comprising isolated nucleic acid encoding a mammalian galanin receptor, cells comprising such vectors, antibodies directed to a mammalian galanin receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian galanin receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding a mammalian galanin receptor, nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian galanin receptor, as well as methods of determining binding of compounds to mammalian galanin receptors.

    摘要翻译： 本发明提供了编码哺乳动物甘丙肽受体的分离的核酸，分离的甘丙肽受体蛋白，包含编码哺乳动物甘丙肽受体的分离的核酸的载体，包含这种载体的细胞，针对哺乳动物甘丙肽受体的抗体，用于检测编码 哺乳动物甘丙肽受体，与编码哺乳动物甘丙肽受体的核酸的唯一序列互补的反义寡核苷酸，表达编码正常或突变型哺乳动物甘丙肽受体的DNA的非人转基因动物，以及确定化合物与哺乳动物甘丙肽受体结合的方法。