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    METHODS FOR ELECTROCHEMICAL ANALYSIS USING MATRIX COMPOSITIONS WITH ALKYLPHENAZINE QUATERNARY SALT AND A NITROSALINE
    1.
    发明申请
    METHODS FOR ELECTROCHEMICAL ANALYSIS USING MATRIX COMPOSITIONS WITH ALKYLPHENAZINE QUATERNARY SALT AND A NITROSALINE 有权
    电化学分析方法使用基质组合物与烷基盐酸季铵盐和硝酸盐

    公开(公告)号：US20110290670A1

    公开(公告)日：2011-12-01

    申请号：US13208420

    申请日：2011-08-12

    申请人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    发明人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    IPC分类号： G01N27/28 ,  G01N33/66

    CPC分类号： C12Q1/006 ,  C12Q1/004 ,  G01N2333/904

    摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

    摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测​​试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。

    BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY
    2.
    发明申请
    BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY 有权
    生物传感器具有改进的分析特异性

    公开(公告)号：US20090246808A1

    公开(公告)日：2009-10-01

    申请号：US12056473

    申请日：2008-03-27

    申请人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    发明人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    IPC分类号： C12Q1/54

    CPC分类号： C12Q1/006 ,  C12Q1/004 ,  G01N2333/904

    摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

    摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测​​试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。

    Methods for electrochemical analysis using matrix compositions with alkylphenazine quaternary salt and a nitrosoaniline
    3.
    发明授权
    Methods for electrochemical analysis using matrix compositions with alkylphenazine quaternary salt and a nitrosoaniline 有权
    使用烷基吩嗪季盐和亚硝基苯胺的基质组成的电化学分析方法

    公开(公告)号：US08535511B2

    公开(公告)日：2013-09-17

    申请号：US13208420

    申请日：2011-08-12

    申请人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    发明人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    IPC分类号： C12Q1/00 ,  G01F1/64 ,  G01N27/26 ,  G01N33/50

    CPC分类号： C12Q1/006 ,  C12Q1/004 ,  G01N2333/904

    摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

    摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测​​试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。

    Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
    4.
    发明授权
    Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline 有权
    具有烷基吩嗪季盐和亚硝基苯胺的基质组成

    公开(公告)号：US08008037B2

    公开(公告)日：2011-08-30

    申请号：US12056473

    申请日：2008-03-27

    申请人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    发明人： Christopher D. Wilsey ,  Mitali Ghoshal ,  Herbert Wieder

    IPC分类号： C12Q1/32

    CPC分类号： C12Q1/006 ,  C12Q1/004 ,  G01N2333/904

    摘要： A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline. The chemistry matrix is used with an electrochemical biosensor to determine the concentration of an analyte after a reaction occurs within the biosensor, at which time an analysis is completed to determine the concentration. A method of determining the concentration of an analyte using the chemistry matrix of glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary salt, and/or a nitrosoaniline is another aspect that is described. The method also further features test times of five seconds or less. Methods utilizing the new chemistry matrix can readily determine an analyte such as blood glucose at concentrations of from about 20-600 mg/dL at a pH of from about 6.5 to about 8.5.

    摘要翻译： 用于测定生物流体中分析物浓度的化学基质包括葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺。 化学基质与电化学生物传感器一起使用以确定在生物传感器内发生反应后分析物的浓度，此时完成分析以确定浓度。 使用葡萄糖脱氢酶，烟酰胺腺嘌呤二核苷酸，烷基吩嗪季盐和/或亚硝基苯胺的化学基质测定分析物的浓度的方法是描述的另一方面。 该方法还进一步具有5秒或更短的测​​试时间。 利用新化学基质的方法可以容易地确定分析物，例如浓度为约20-600mg / dL的分析物，pH为约6.5至约8.5。

    Electrical connection system for electrochemical analysis system
    5.
    发明授权
    Electrical connection system for electrochemical analysis system 失效
    电化学分析系统电气连接系统

    公开(公告)号：US07754152B2

    公开(公告)日：2010-07-13

    申请号：US11295187

    申请日：2005-12-06

    申请人： Stefan Riebel ,  Bruno Robert Thoes ,  Manfred Augstein ,  Herbert Wieder ,  Gregor Bainczyk

    发明人： Stefan Riebel ,  Bruno Robert Thoes ,  Manfred Augstein ,  Herbert Wieder ,  Gregor Bainczyk

    IPC分类号： G01N27/00

    CPC分类号： G01N33/4875 ,  Y10T29/49002

    摘要： The invention relates to an electrical connection system for an analysis system and a method for analysis of a liquid sample on an analytical test element using the described analysis system. The analysis system comprises an evaluation appliance for evaluation of electrical signals, a test element holder for holding and positioning of an analytical test element in a measurement position, and at least one electrical contact element configured to make electrical contact with at least one electrical contact surface of an analytical test element, and to produce an electrical connection between the contact surface and the evaluation appliance. The at least one contact element is arranged to move to contact the contact surface of a test element held either in a fixed test element holder or a moveable test element holder, such as a slide. Furthermore, the analysis system has a means for moving the electrical contact element to the electrical contact surface of an analytical test element when the test element holder is in the measurement position.

    摘要翻译： 本发明涉及用于分析系统的电连接系统和使用所述分析系统分析测试元件上的液体样品的方法。 分析系统包括用于评估电信号的评估装置，用于在测量位置保持和定位分析测试元件的测试元件保持器，以及配置成与至少一个电接触表面进行电接触的至少一个电接触元件 的分析测试元件，并且在接触表面和评估设备之间产生电连接。 所述至少一个接触元件布置成移动以接触保持在固定测试元件保持器或可移动测试元件保持器（例如滑块）中的测试元件的接触表面。 此外，分析系统具有当测试元件保持器处于测量位置时将电接触元件移动到分析测试元件的电接触表面的装置。

    Displacement assay for the detection of nucleic acid oligomer hybridization events
    7.
    发明申请
    Displacement assay for the detection of nucleic acid oligomer hybridization events 审中-公开
    用于检测核酸低聚物杂交事件的位移测定

    公开(公告)号：US20060228703A1

    公开(公告)日：2006-10-12

    申请号：US10487816

    申请日：2002-08-26

    申请人： Gerhard Hartwich ,  Peter Frischmann ,  Ute Haker ,  Herbert Wieder

    发明人： Gerhard Hartwich ,  Peter Frischmann ,  Ute Haker ,  Herbert Wieder

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6825 ,  C12Q2545/107

    摘要： Described is a method for detection of nucleic acid oligomer hybridization events, the method comprising the steps: providing a modified surface, the modification consisting in the attachment of at least one type of ligate nucleic acid oligomer; providing signal nucleic acid oligomer ligands; providing a sample having nucleic acid oligomer ligands; bringing a defined quantity of the signal nucleic acid oligomer ligands into contact with the modified surface and bringing the sample and the nucleic acid oligmer ligands contained therein into contact with the modified surface; detecting the signal nucleic acid oligomer ligands; and comparing with reference values the values obtained from the detection of the signal nucleic acid oligomer ligands.

    摘要翻译： 描述了用于检测核酸寡聚体杂交事件的方法，所述方法包括以下步骤：提供修饰的表面，所述修饰组合在至少一种类型的连接核酸寡聚体的连接中; 提供信号核酸寡聚体配体; 提供具有核酸低聚物配体的样品; 使定义量的信号核酸低聚物配体与修饰表面接触并使其中含有的样品和核酸寡聚体配体与改性表面接触; 检测信号核酸低聚物配体; 并且与参考值比较，从检测信号核酸低聚物配体获得的值。

    In Vivo Analyte Monitor With Malfunction Detection
    10.
    发明申请
    In Vivo Analyte Monitor With Malfunction Detection 有权
    体内分析物监测仪故障检测

    公开(公告)号：US20090057148A1

    公开(公告)日：2009-03-05

    申请号：US12201649

    申请日：2008-08-29

    申请人： Herbert Wieder ,  Michael Marquant

    发明人： Herbert Wieder ,  Michael Marquant

    IPC分类号： G01N33/487 ,  G01N27/26

    CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B2560/0271

    摘要： The measuring system for in vivo monitoring of an analyte concentration with malfunction detection, comprises an electrode system, a potentiostat and an evaluation unit. The electrode system has a working electrode, a reference electrode, and a counter electrode. The potentiostat is for adjusting a difference of potential between the electric potential of the working electrode and the electric potential of the reference electrode to a specified value and for measuring an electric current flowing between the working electrode and the counter electrode. The potentiostat comprises a working electrode terminal for connection to the working electrode, a reference electrode terminal for connection to the reference electrode, and a counter electrode terminal for connection to the counter electrode. The evaluation unit monitors the electric potential of the counter electrode and generates a malfunction signal when said potential is outside a specified reference range. A method of operation is also disclosed.

    摘要翻译： 用于在具有故障检测的体内监测分析物浓度的测量系统包括电极系统，恒电位仪和评估单元。 电极系具有工作电极，参比电极和对电极。 恒电位仪用于将工作电极的电位和参考电极的电位之间的电位差调整到规定值，并测量在工作电极和对电极之间流动的电流。 恒电位仪包括用于连接到工作电极的工作电极端子，用于连接到参考电极的参考电极端子和用于连接到对电极的对电极端子。 评估单元监视对电极的电位，并且当所述电位在指定的参考范围之外时产生故障信号。 还公开了一种操作方法。