公开(公告)号：US08575205B2

公开(公告)日：2013-11-05

申请号：US13427664

申请日：2012-03-22

申请人： Theodore J. Nitz ,  Janet A. Gaboury ,  Christopher J. Burns ,  Sylvie Laguerre ,  Daniel C. Pevear ,  Thomas A. Lessen ,  David J. Rys

发明人： Theodore J. Nitz ,  Janet A. Gaboury ,  Christopher J. Burns ,  Sylvie Laguerre ,  Daniel C. Pevear ,  Thomas A. Lessen ,  David J. Rys

IPC分类号： A61K31/41 ,  C07D257/06

CPC分类号： C07D275/02 ,  A61K31/11 ,  A61K31/136 ,  A61K31/18 ,  A61K31/196 ,  A61K31/222 ,  A61K31/357 ,  A61K31/41 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  C07C47/565 ,  C07C69/18 ,  C07C223/06 ,  C07C235/16 ,  C07C235/68 ,  C07C311/29 ,  C07D211/32 ,  C07D257/04 ,  C07D401/14 ,  C07D407/10 ,  C07D417/14

摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

公开(公告)号：US20130233924A1

公开(公告)日：2013-09-12

申请号：US13787196

申请日：2013-03-06

申请人： Christopher J. Burns

发明人： Christopher J. Burns

IPC分类号： G06K7/015 ,  G06K7/06

CPC分类号： G06K7/0056 ,  G06K7/0021 ,  G06K7/015 ,  G06K7/10366 ,  G06K19/005 ,  G06K19/07739 ,  G06K19/07741 ,  G06K19/07743 ,  G06K19/07762

摘要： A smartcard unit includes at least a smartcard and an attachment enabling the smartcard unit to be worn by a user. The smartcard is accessible to an external reader. A reader unit interfaces with the smartcard to enable an external computer to communicate with the smartcard. The smartcard unit or the reader unit has structure to align the reader unit relative to the smartcard unit in an alignment for communicative interfacing while the smartcard unit is being worn. The smartcard unit or the reader unit has a retainer to secure the reader unit in alignment relative to the smartcard so that the smartcard unit is reversibly separable from the reader unit without damage, in response to a force less than is necessary to detach or damage another part of said system, other than along a longitudinal axis of the smartcard or of a pair of components being separated.

公开(公告)号：US08119672B2

公开(公告)日：2012-02-21

申请号：US10524313

申请日：2003-08-11

申请人： David J. Rys ,  Theodore J. Nitz ,  Janet A Gaboury ,  Christopher J. Burns ,  Daniel C. Pevear ,  Thomas A. Lessen ,  Torsten Herbertz

发明人： David J. Rys ,  Theodore J. Nitz ,  Janet A Gaboury ,  Christopher J. Burns ,  Daniel C. Pevear ,  Thomas A. Lessen ,  Torsten Herbertz

IPC分类号： A61K31/41 ,  C07D43/02

CPC分类号： C07D257/04 ,  A61K31/41 ,  A61K38/21 ,  A61K39/395

摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

摘要翻译： 提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

公开(公告)号：US6057369A

公开(公告)日：2000-05-02

申请号：US928943

申请日：1997-09-12

申请人： Robert D. Groneberg ,  Kent W. Neuenschwander ,  Stevan W. Djuric ,  Gerald M. McGeehan ,  Christopher J. Burns ,  Steven M. Condon ,  Matthew M. Morrissette ,  Joseph M. Salvino ,  Anthony C. Scotese ,  John W. Ullrich

发明人： Robert D. Groneberg ,  Kent W. Neuenschwander ,  Stevan W. Djuric ,  Gerald M. McGeehan ,  Christopher J. Burns ,  Steven M. Condon ,  Matthew M. Morrissette ,  Joseph M. Salvino ,  Anthony C. Scotese ,  John W. Ullrich

IPC分类号： C07D333/24 ,  A61K31/00 ,  A61K31/165 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/47 ,  A61P3/00 ,  A61P3/10 ,  A61P11/00 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/00 ,  A61P19/02 ,  A61P19/08 ,  A61P25/28 ,  A61P27/00 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P33/00 ,  A61P33/06 ,  A61P37/00 ,  C07C215/08 ,  C07C259/06 ,  C07C317/44 ,  C07C323/60 ,  C07C323/65 ,  C07D209/48 ,  C07D215/14 ,  C07D317/56 ,  C07D317/62 ,  A01N37/28

CPC分类号： C07D209/48 ,  C07C259/06 ,  C07C317/44 ,  C07C323/60 ,  C07D215/14 ,  C07D317/56 ,  C07D317/62 ,  C07C2101/08

摘要： This invention is directed to compounds of formula I: ##STR1## wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. Compounds within the scope of the present invention may also inhibit an MMP, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting MMPs, such disease states involve tissue breakdown and those associated with a physiologically detrimental excess of TNF. The present invention is therefore also directed to the pharmaceutical use of the compounds, pharmaceutical compositions containing the compounds, intermediates leading thereto and methods for the preparation of the compounds and their intermediates.

摘要翻译： 本发明涉及式I化合物：其中变量如本文所述。 本发明范围内的化合物具有有用的性质，更具体地说是药物性质。 它们特别可用于抑制TNF治疗患有与生理有害过量的肿瘤坏死因子（TNF）相关的疾病状态的患者的生产或生理作用。 本发明范围内的化合物还抑制环AMP磷酸二酯酶，并且可用于治疗与通过抑制环AMP磷酸二酯酶调节的病理状况相关的疾病状态，所述疾病状态包括炎性和自身免疫性疾病，特别是IV型环AMP 磷酸二酯酶。 本发明范围内的化合物还可以抑制MMP，并且可用于治疗与通过抑制MMP调节的病理状态相关的疾病状态，这种疾病状态涉及组织分解以及与生理上有害的过量TNF相关的疾病状态。 因此，本发明还涉及化合物的药物用途，含有这些化合物的药物组合物，导致其的中间体以及制备化合物及其中间体的方法。

公开(公告)号：US5317015A

公开(公告)日：1994-05-31

申请号：US877574

申请日：1992-05-01

申请人： John W. Ullrich ,  Raymond D. Youssefyeh ,  Daniel L. Cheney ,  Christopher J. Burns

发明人： John W. Ullrich ,  Raymond D. Youssefyeh ,  Daniel L. Cheney ,  Christopher J. Burns

IPC分类号： A61K31/66 ,  A61K31/675

CPC分类号： A61K31/675 ,  A61K31/66 ,  Y10S514/824

摘要： This invention relates to a method of lowering abnormally high serum cholesterol levels in the body without significantly reducing mevalonic metabolite synthesis and to novel pharmacological compositions containing as an active ingredient bisphosphonic acid and ester compounds containing a mono-, bi- or tricyclic ring linked with a bisphosphonate moiety through a basic amino alkylene group. This invention also provides novel bisphosphonate compounds and the processes for their preparation.

摘要翻译： 本发明涉及一种降低身体异常高血清胆固醇水平而不显着降低甲羟戊酸代谢物合成的方法，以及含有作为活性成分的双膦酸的新型药物组合物和含有与一个或多个 双膦酸酯部分通过碱性氨基亚烷基。 本发明还提供了新的双膦酸盐化合物及其制备方法。

公开(公告)号：US06599918B2

公开(公告)日：2003-07-29

申请号：US10081113

申请日：2002-02-22

申请人： Christopher J. Burns ,  William P. Dankulich ,  Daniel G. McGarry ,  Francis A. Volz

发明人： Christopher J. Burns ,  William P. Dankulich ,  Daniel G. McGarry ,  Francis A. Volz

IPC分类号： A61K31443

CPC分类号： C07D405/12 ,  C07D307/81 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04

摘要： This invention is directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans that inhibit Factor Xa, pharmaceutical compositions comprising these compounds and their use for inhibiting Factor Xa or treating pathological conditions in a patient that may be ameliorated by administration of such compounds. This invention is also is also directed to substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benzopyrans which directly inhibit both Factor Xa and Factor IIa (thrombin), to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds and to a method of simultaneously directly inhibiting both Factor Xa and Factor IIa (thrombin).

公开(公告)号：US09321739B2

公开(公告)日：2016-04-26

申请号：US13216106

申请日：2011-08-23

申请人： David J. Rys ,  Theodore J. Nitz ,  Janet A. Gaboury ,  Christopher J. Burns ,  Daniel C. Pevear ,  Thomas A. Lessen ,  Torsten Herbertz

发明人： David J. Rys ,  Theodore J. Nitz ,  Janet A. Gaboury ,  Christopher J. Burns ,  Daniel C. Pevear ,  Thomas A. Lessen ,  Torsten Herbertz

IPC分类号： A61K31/41 ,  A61K38/21 ,  A61K39/395 ,  A61K31/7056 ,  A61K31/14 ,  C07D257/04

CPC分类号： C07D257/04 ,  A61K31/41 ,  A61K38/21 ,  A61K39/395

摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

公开(公告)号：US09135478B2

公开(公告)日：2015-09-15

申请号：US13787196

申请日：2013-03-06

申请人： Christopher J. Burns

发明人： Christopher J. Burns

IPC分类号： G06K7/06 ,  G06K7/015 ,  G06K19/077 ,  G06K19/00 ,  G06K7/00

CPC分类号： G06K7/0056 ,  G06K7/0021 ,  G06K7/015 ,  G06K7/10366 ,  G06K19/005 ,  G06K19/07739 ,  G06K19/07741 ,  G06K19/07743 ,  G06K19/07762

摘要： A smartcard unit includes at least a smartcard and an attachment enabling the smartcard unit to be worn by a user. The smartcard is accessible to an external reader. A reader unit interfaces with the smartcard to enable an external computer to communicate with the smartcard. The smartcard unit or the reader unit has structure to align the reader unit relative to the smartcard unit in an alignment for communicative interfacing while the smartcard unit is being worn. The smartcard unit or the reader unit has a retainer to secure the reader unit in alignment relative to the smartcard so that the smartcard unit is reversibly separable from the reader unit without damage, in response to a force less than is necessary to detach or damage another part of said system, other than along a longitudinal axis of the smartcard or of a pair of components being separated.

摘要翻译： 智能卡单元至少包括智能卡和使得智能卡单元能够被用户佩戴的附件。 智能卡可由外部读卡器访问。 读卡器单元与智能卡连接，以使外部计算机与智能卡通信。 智能卡单元或读取器单元具有将读取器单元相对于智能卡单元对准的结构，以便在智能卡单元被穿着的同时进行通信接口。 智能卡单元或读取器单元具有固定器以固定读取器单元相对于智能卡的对准，使得智能卡单元可响应于小于分离或损坏另一个所需的力而不受损坏地与读取器单元可逆地分离 所述系统的一部分，除了沿智能卡的纵向轴线或分离的一对部件之外。

公开(公告)号：US08216218B2

公开(公告)日：2012-07-10

申请号：US12171010

申请日：2008-07-10

申请人： Christopher J. Burns ,  Marlo Cinco

发明人： Christopher J. Burns ,  Marlo Cinco

IPC分类号： A61B18/04

CPC分类号： A61B18/14 ,  A61B2017/0088 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00083 ,  A61B2018/00095 ,  A61B2018/00107 ,  A61B2018/0016 ,  A61B2018/00452 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/124 ,  A61B2018/1467 ,  A61N1/403

摘要： Apparatus and methods for treating skin conditions that deliver high frequency energy across large tissue areas. The treatment apparatus comprises a treatment tip carrying a plurality of electrodes that are switched such that fewer than all of the electrodes are concurrently energized. The treatment tip includes a cooling mechanism that cools near-surface tissue regions disposed between the skin surface and the treated tissue by cooling the respective electrode that treats each of the regions. The cooling mechanism may include a heat transfer body intervening between the electrodes and a fluid delivery member configured to discharge coolant that impinges the heat transfer body. Alternatively, the cooling mechanism may include a fluid delivery member having individually valve-controlled passages configured to discharge a dedicated stream of coolant at each of the electrodes, a thermoelectric cooler, or a closed-loop fluid delivery member.

摘要翻译： 用于治疗在大组织区域传递高频能量的皮肤状况的装置和方法。 处理装置包括承载多个电极的处理尖端，所述多个电极被切换成使得少于全部电极同时通电。 处理尖端包括通过冷却处理每个区域的各个电极来冷却设置在皮肤表面和处理过的组织之间的近表面组织区域的冷却机构。 冷却机构可以包括介于电极之间的传热体和构造成排出撞击传热体的冷却剂的流体输送构件。 或者，冷却机构可以包括流体输送构件，其具有单独的阀控制通道，其被配置为在每个电极，热电冷却器或闭环流体输送构件处排出专用冷却剂流。

公开(公告)号：US20100317621A1

公开(公告)日：2010-12-16

申请号：US12742548

申请日：2008-11-13

申请人： Christopher J. Burns ,  Randy W. Jackson

发明人： Christopher J. Burns ,  Randy W. Jackson

IPC分类号： A61K31/69 ,  C07F5/02 ,  C12N1/20 ,  A61P31/04

CPC分类号： C07F5/025

摘要： Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.