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公开(公告)号：US20090093393A1
公开(公告)日：2009-04-09
申请号：US12099632
申请日：2008-04-08
CPC分类号： G01N33/54393 , C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method.
摘要翻译： 公开了一种选择性靶向方法，其包括将配体文库，特别是肽文库与抗靶相接触，以允许配体结合抗靶; 将非结合配体与抗靶结合配体分离，使非结合抗靶配体与允许未结合配体与靶结合以形成靶结合配体复合物的靶; 将靶结合的配体络合物与不结合靶的配体分离，并鉴定靶结合的配体配合物上的靶结合配体，其中靶结合配体的KD在约10-7至10范围内 另外要求的是根据该方法鉴定的配体。
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公开(公告)号：US08318640B2
公开(公告)日：2012-11-27
申请号：US12099632
申请日：2008-04-08
CPC分类号： G01N33/54393 , C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method.
摘要翻译： 公开了一种选择性靶向方法，其包括将配体文库，特别是肽文库与抗靶相接触，以允许配体结合抗靶; 将非结合配体与抗靶结合配体分离，使非结合抗靶配体与允许未结合配体与靶结合以形成靶结合配体复合物的靶; 将靶结合的配体络合物与不结合靶的配体分离，并鉴定靶结合的配体配合物上的靶结合配体，其中靶结合配体的KD在约10-7至10范围内 另外要求的是根据该方法鉴定的配体。
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公开(公告)号：US20050112692A1
公开(公告)日：2005-05-26
申请号：US10968732
申请日：2004-10-19
申请人： Christopher Murray , Pilar Tijerina , David Estell , Yiyou Chen
发明人： Christopher Murray , Pilar Tijerina , David Estell , Yiyou Chen
IPC分类号： G01N33/50 , A61K38/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/00 , C12N15/09 , C12N15/10 , C12Q1/68 , C40B40/02 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/543
CPC分类号： G01N33/54393 , C07K7/06 , C07K7/08 , C12N15/1034 , C12N15/1037 , C12N15/1072 , C40B40/02 , G01N33/6845 , G01N2500/02
摘要： A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10−7 to 10−10 M. Additionally claimed are the ligands identified according to the method.
摘要翻译： 公开了一种选择性靶向方法，其包括将配体文库，特别是肽文库与抗靶相接触，以允许配体结合抗靶; 将非结合配体与抗靶结合配体分离，使非结合抗靶配体与允许未结合配体与靶结合以形成靶结合配体复合物的靶; 将靶结合的配体络合物与不结合靶的配体分离，以及鉴定靶结合的配体配合物上的靶结合配体，其中靶结合的配体在其中具有一个K < 范围为约10 -7至10 -10 M。 另外要求保护的是根据该方法鉴定的配体。
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公开(公告)号：US08293702B2
公开(公告)日：2012-10-23
申请号：US12144572
申请日：2008-06-23
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K2319/20
摘要： The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.
摘要翻译： 本申请涉及结合单宁，多酚或花青素化合物的肽，特别是涉及织物或其他表面上的茶和酒渍。 本发明还涉及结合肽缀合物，其包括与药剂偶联的结合肽和结合肽缀合物用于将药剂递送至所需靶标的用途。
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公开(公告)号：US20090081178A1
公开(公告)日：2009-03-26
申请号：US12144572
申请日：2008-06-23
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K2319/20
摘要： The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.
摘要翻译： 本申请涉及结合单宁，多酚或花青素化合物的肽，特别是涉及织物或其他表面上的茶和酒渍。 本发明还涉及结合肽缀合物，其包括与药剂偶联的结合肽和结合肽缀合物用于将药剂递送至所需靶标的用途。
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公开(公告)号：US20060135433A1
公开(公告)日：2006-06-22
申请号：US10528514
申请日：2003-10-06
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K2319/20 , Y02A50/473
摘要： The present application relates to peptides which bind to tannin, polyphenolic or anthocyanin compounds, and particularly to tea and wine stains on a fabric or other surface. The invention also concerns binding peptide conjugates which includes a binding peptide coupled to an agent and the use of the binding peptide conjugate for delivering an agent to a desired target.
摘要翻译： 本申请涉及结合单宁，多酚或花青素化合物的肽，特别是涉及织物或其他表面上的茶和酒渍。 本发明还涉及结合肽缀合物，其包括与药剂偶联的结合肽和结合肽缀合物用于将药剂递送至所需靶标的用途。
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