公开(公告)号：US20130266989A1

公开(公告)日：2013-10-10

申请号：US13792103

申请日：2013-03-10

申请人： Christopher L. Parks ,  Kevin J. Wright ,  Maoli Yuan ,  Christy K. Jurgens ,  Xinsheng Zhang ,  Arban Domi ,  Simon Hoffenberg ,  Maria J. Chiuchiolo ,  Svetlana Rabinovich ,  Aaron J. Wilson ,  Ivo C. Lorenz

发明人： Christopher L. Parks ,  Kevin J. Wright ,  Maoli Yuan ,  Christy K. Jurgens ,  Xinsheng Zhang ,  Arban Domi ,  Simon Hoffenberg ,  Maria J. Chiuchiolo ,  Svetlana Rabinovich ,  Aaron J. Wilson ,  Ivo C. Lorenz

IPC分类号： C12N15/68

CPC分类号： C12N15/68 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N15/67 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2760/16034 ,  C12N2760/18443 ,  C12N2760/20243

摘要： The present invention relates to methods of developing gene inserts that are more compatible with the host vectors by modifying a protein sequence to lessen potential interference with vector propagation while ensuring that the protein is expressed and processed efficiently and maintains desired structural features, and designing a gene with a nucleotide sequence that resembles the base composition of the host vector genome.

摘要翻译： 本发明涉及通过修饰蛋白质序列来改变与宿主载体更相容的基因插入物的方法，以减少对载体繁殖的潜在干扰，同时确保蛋白质被有效地表达和加工并保持所需的结构特征，并设计基因 其核苷酸序列类似于宿主载体基因组的基本组成。

公开(公告)号：US20170258890A1

公开(公告)日：2017-09-14

申请号：US15498554

申请日：2017-04-27

申请人： John Coleman ,  Josephine Helena Cox ,  Arban Domi ,  Hiroto Hara ,  Takashi Hironaka ,  Makoto Inoue ,  Dagna Skoog Laufer ,  Angela Grazia Lombardo ,  Christopher L. Parks ,  Eddy Sayeed ,  Maoli Yuan ,  Xinsheng Zhang

发明人： John Coleman ,  Josephine Helena Cox ,  Arban Domi ,  Hiroto Hara ,  Takashi Hironaka ,  Makoto Inoue ,  Dagna Skoog Laufer ,  Angela Grazia Lombardo ,  Christopher L. Parks ,  Eddy Sayeed ,  Maoli Yuan ,  Xinsheng Zhang

IPC分类号： A61K39/21 ,  C07K14/005 ,  C12N15/86 ,  C12N7/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16271 ,  C12N2740/16334 ,  C12N2760/18443 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2760/20243

摘要： The present invention relates to genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes, methods for making the same and cell substrates qualified for vaccine production which may comprise genetically stable replication competent Sendai virus vector(s) containing optimized HIV genes.

公开(公告)号：US20170258891A1

公开(公告)日：2017-09-14

申请号：US15498556

申请日：2017-04-27

申请人： Christopher L. Parks ,  Maoli Yuan ,  Xinsheng Zhang ,  Aaron Wilson ,  Angela Grazia Lombardo ,  Eddy Sayeed ,  Josephine Helena Cox ,  Takashi Hironaka ,  Makoto Inoue ,  Hiroto Hara

发明人： Christopher L. Parks ,  Maoli Yuan ,  Xinsheng Zhang ,  Aaron Wilson ,  Angela Grazia Lombardo ,  Eddy Sayeed ,  Josephine Helena Cox ,  Takashi Hironaka ,  Makoto Inoue ,  Hiroto Hara

IPC分类号： A61K39/21 ,  C12N15/86 ,  C12N7/00

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/57 ,  A61K2039/575 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16271 ,  C12N2740/16334 ,  C12N2760/18443 ,  C12N2760/18843 ,  C12N2760/18871 ,  C12N2760/20243

摘要： The present invention relates to a vector(s) containing and expressing an optimized HIV EnvF gene, methods for making the same and cell substrates qualified for vaccine production which may comprise vector(s) containing optimized HIV genes.