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    Pyrrolobenzodiazepines
    3.
    发明申请
    Pyrrolobenzodiazepines 有权
    吡咯并苯并二氮杂卓

    公开(公告)号：US20060148788A1

    公开(公告)日：2006-07-06

    申请号：US11367241

    申请日：2006-03-02

    申请人： David Thurston ,  Philip Howard

    发明人： David Thurston ,  Philip Howard

    IPC分类号： A61K31/551 ,  C07D487/02

    CPC分类号： C07D487/04

    摘要： A compound of the formula II: wherein: R′2 is CHR″2, where R″2 is H. R6 and R9 are H and R7 is OMe and the compound is a dimer with each monomer being the same and being of formula II, where the R8 groups of the monomers form together a bridge having the formula —O—(CH2)p—O—, where p is 5, linking the monomers.

    摘要翻译： 式II的化合物：其中：R'2是CHR“2，其中R”2是H.R 6和R 9是H，R 7是OMe，并且化合物是每个单体相同并且是式II的二聚体，其中 单体的R 8基团一起形成具有式-O-（CH 2 CH 2）p -O-的桥，其中p为5 ，连接单体。

    Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
    6.
    发明申请
    Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto 失效
    吡咯并苯并二氮杂衍生物，包含其的组合物及其相关方法

    公开(公告)号：US20070072846A1

    公开(公告)日：2007-03-29

    申请号：US10576689

    申请日：2004-10-22

    申请人： B. Vishnuvajjala ,  Paul Liu ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Luke Hsiao ,  Gregory Turner

    发明人： B. Vishnuvajjala ,  Paul Liu ,  Kenneth Snader ,  David Thurston ,  Philip Howard ,  Luke Hsiao ,  Gregory Turner

    IPC分类号： A61K31/551 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： Disclosed are compounds of Formula (I) wherein X, Y, Ri-R7,T1, T2, Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.

    摘要翻译： 公开了式（I）的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p是 如本文所述; 包含式（I）化合物和载体的药物组合物; 抑制细胞生长的方法，该方法包括以有效抑制生长的量施用式（I）化合物; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的量施用式（I）化合物; 治疗细胞的病毒，寄生或细菌感染的方法，所述方法包括以有效治疗病毒，寄生或细菌感染的量施用式（I）化合物; 和制备本文所述的式（I）化合物的方法。

    Pyrrolobenzodiazepines
    7.
    发明申请
    Pyrrolobenzodiazepines 有权
    吡咯并苯并二氮杂卓

    公开(公告)号：US20060128693A1

    公开(公告)日：2006-06-15

    申请号：US10534825

    申请日：2003-11-14

    申请人： David Thurston ,  Philip Howard

    发明人： David Thurston ,  Philip Howard

    IPC分类号： A61K31/551 ,  C07D487/04

    CPC分类号： C07D487/04 ,  A61K31/551

    摘要： Compounds of formula (I): formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are C disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a phenyl group substituted by: one or more chloro or fluoro groups; an ethyl or propyl group; a 4-t-butyl group; a 2-methyl group; or two methyl groups in the 2- and 6- positions.

    摘要翻译： 式（I）化合物：式（I）及其盐，溶剂化物，化学保护形式及其前体是C公开的，其中R 2选自：任选取代的萘基; 任选取代的噻吩基或呋喃基; 和被一个或多个氯或氟基取代的苯基; 乙基或丙基; 4-叔丁基; 2-甲基; 或2-和6-位的两个甲基。

    Fuel composition
    8.
    发明授权
    Fuel composition 有权
    燃油组成

    公开(公告)号：US07553404B2

    公开(公告)日：2009-06-30

    申请号：US11980821

    申请日：2007-10-31

    申请人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

    发明人： Alisdair Quentin Clark ,  Philip Howard ,  Anthony George William Parker

    IPC分类号： C10G7/02

    CPC分类号： C10L1/023 ,  C10L1/02 ,  C10L1/04 ,  C10L1/06

    摘要： A process for preparing at least two compositions suitable for production of gasoline, which process comprises: fractionating an alkylation product to produce a first cut boiling in the range 90-106° C., a second cut boiling at temperature lower than said first cut, and a third cut boiling at a temperature above said first Cut, blending at least 2% by volume of said first cut with at least 5% of a component selected from at least one of a paraffin, an aromatic hydrocarbon and an olefinic hydrocarbon, said component having a boiling point of 60-160° C., wherein not more than 5% of the total composition of hydrocarbon has a boiling point of more than 160° C. and wherein said composition comprises less than 5% of 2,2,3-trimethylbutane or 2,2,3-trimethylpentane, to produce a first high octane unleaded gasoline composition of RON at least 97 and MON value at least 86, and incorporating said second and third cuts with said component to produce a second high octane unleaded gasoline composition of RON at least 92 and MON value at least 80.

    摘要翻译： 一种制备适于生产汽油的至少两种组合物的方法，该方法包括：分馏烷基化产物以产生在90-106℃范围内的第一次沸腾，在低于所述第一次切割的温度下进行第二次沸腾， 和在高于所述第一馏分的温度下沸腾的第三馏分，将至少2体积％的所述第一馏分与至少5％的选自至少一种石蜡，芳族烃和烯烃的组分共混，所述 沸点为60-160℃的组分，其中不超过组合物总组合物的5％具有大于160℃的沸点，并且其中所述组合物包含少于5重量％的2,2， 3-三甲基丁烷或2,2,3-三甲基戊烷，以产生至少97的RON的第一高辛烷值无铅汽油组合物，并且MON值至少为86，并且将所述第二和第三切割与所述组分并入以产生无铅的第二高辛烷值 汽油组合 RON至少为92，MON值至少为80。

    Polymerization process
    10.
    发明授权
    Polymerization process 失效
    聚合过程

    公开(公告)号：US06300437B1

    公开(公告)日：2001-10-09

    申请号：US08904437

    申请日：1997-07-31

    申请人： Philip Howard ,  Peter James Maddox ,  Stephen Roy Partington

    发明人： Philip Howard ,  Peter James Maddox ,  Stephen Roy Partington

    IPC分类号： C08F442

    CPC分类号： C08F210/16 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  C08F10/00 ,  Y10S526/901 ,  Y10S526/943 ,  C08F210/14 ,  C08F2500/09 ,  C08F2500/20 ,  C08F2500/12 ,  C08F2500/26

    摘要： A process for preparing polyolefins having at least 0.01 long chain branches (LCB)/1000 carbon atoms along the polymer backbone as measured by flow activation and a molecular weight distribution greater than 2.5 comprises polymerization in the presence of a metallocene complex having the formula: wherein Cp1, Cp2 are independently a substituted or unsubstituted indenyl or hydrogenated indenyl group, Y is a univalent anionic ligand, M is zirconium, titanium or hafnium, and Z is a bridging group comprising an alkylene group having 1 to 20 carbon atoms or a dialkyl silyl- or germyl- group, or alkyl phophine or amine radical. Polyolefins prepared from such a process show specific flow activation energy/LCB relationships.

    摘要翻译： 通过流动活化和大于2.5的分子量分布测量，制备沿着聚合物主链具有至少0.01个长支链（LCB）/ 1000个碳原子的聚烯烃的方法包括在具有下式的茂金属络合物存在下聚合：其中Cp1 ，Cp2独立地是取代或未取代的茚基或氢化茚基，Y是一价阴离子配体，M是锆，钛或铪，Z是包含具有1至20个碳原子的亚烷基的桥连基或二烷基甲硅烷基或 甲锗烷基或烷基磷或胺基。 从这种方法制备的聚烯烃显示出特定的流动活化能/ LCB关系。