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公开(公告)号：US20090189069A1
公开(公告)日：2009-07-30
申请号：US12314520
申请日：2008-12-11
CPC分类号： H01J49/4265 , H01J49/0077 , H01J49/025
摘要： A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
摘要翻译： 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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2.发明授权公开(公告)号：US08963075B2
公开(公告)日：2015-02-24
申请号：US12314520
申请日：2008-12-11
CPC分类号： H01J49/4265 , H01J49/0077 , H01J49/025
摘要： A novel system and method for charge-monitoring mass spectrometry is provided. The mass spectrometer can be used to measure the mass of one or more analytes having masses in the range of about a few Daltons to more than about 1015 Daltons. The invention can be used for rapid mass distribution measurements. For example, the system and method can be used to distinguish cancer cells from normal cells when their mass distributions are different.
摘要翻译： 提供了一种电荷监测质谱的新型系统和方法。 质谱仪可用于测量质量在约几道尔顿至大于约1015道尔顿范围内的一种或多种分析物的质量。 本发明可用于快速质量分布测量。 例如，当它们的质量分布不同时，系统和方法可以用于区分癌细胞与正常细胞。
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3.发明授权公开(公告)号：US09459247B2
公开(公告)日：2016-10-04
申请号：US13075160
申请日：2011-03-29
申请人： Huan-Chang Lin , Hsin-Hung Lin , Cai-Yu Kao , Alice L Yu , Wen-Ping Peng , Chung-Hsuan Chen
发明人： Huan-Chang Lin , Hsin-Hung Lin , Cai-Yu Kao , Alice L Yu , Wen-Ping Peng , Chung-Hsuan Chen
IPC分类号： A61K45/06 , C12Q1/70 , G01N33/50 , G01N33/569 , G01N33/68
CPC分类号： G01N33/5091 , G01N33/5008 , G01N33/569 , G01N33/6848
摘要： Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.
摘要翻译： 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。
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公开(公告)号：US06435343B1
公开(公告)日：2002-08-20
申请号：US09685979
申请日：2000-10-10
申请人： Jyh-Ming Wu , Yu-Pan Pai , Huan-Chang Lin
发明人： Jyh-Ming Wu , Yu-Pan Pai , Huan-Chang Lin
IPC分类号： B65D8557
CPC分类号： G11B23/00 , G11B33/045
摘要： A disk magazine for accessing Compact Disks includes a bottom stage, a vertical shaft fixed and supported at the bottom stage, a prop-up piece being loaded with Compact Disks and having an opening through which the vertical shaft extends, a barrel tightly combined with the bottom stage at the lower end, and a lid tightly covering up the upper side of the bottom stage. The lid is provided with a fixing hole into which the tapering tip pole of the vertical shaft inserts, and two O-rings are used for sealing between the lid and barrel, as well as between the bottom stage and barrel respectively to prevent the disk magazine from the environmental contamination.
摘要翻译： 用于访问紧凑型盘的磁盘盒包括底部，在底部固定和支撑的垂直轴，支撑件，其装载有紧凑盘，并具有垂直轴延伸的开口，紧紧地与 底部底部，盖子紧紧地覆盖底部的上侧。 盖设有一个固定孔，垂直轴的锥形尖端插入到该固定孔中，两个O形圈用于密封盖和桶之间以及底部和桶之间，以防止盘盒 从环境污染。
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