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    Quantitative measurement of nano/micro particle endocytosis with cell mass spectrometry
    1.
    发明授权
    Quantitative measurement of nano/micro particle endocytosis with cell mass spectrometry 有权
    用细胞质谱法定量测定纳米/微粒内吞

    公开(公告)号：US09459247B2

    公开(公告)日：2016-10-04

    申请号：US13075160

    申请日：2011-03-29

    Applicant: Huan-Chang Lin ,  Hsin-Hung Lin ,  Cai-Yu Kao ,  Alice L Yu ,  Wen-Ping Peng ,  Chung-Hsuan Chen

    Inventor： Huan-Chang Lin ,  Hsin-Hung Lin ,  Cai-Yu Kao ,  Alice L Yu ,  Wen-Ping Peng ,  Chung-Hsuan Chen

    IPC: A61K45/06 ,  C12Q1/70 ,  G01N33/50 ,  G01N33/569 ,  G01N33/68

    CPC classification number: G01N33/5091 ,  G01N33/5008 ,  G01N33/569 ,  G01N33/6848

    Abstract: Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.

    Abstract translation: 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。

    QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY
    3.
    发明申请
    QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY 审中-公开
    纳米/微粒子内毒素与细胞质谱的定量测量

    公开(公告)号：US20110236882A1

    公开(公告)日：2011-09-29

    申请号：US13075160

    申请日：2011-03-29

    Applicant: Huan-Chang LIN ,  Hsin-Hung LIN ,  Cai-Yu KAO ,  Alice L. Yu ,  Wen-Ping PENG ,  Chung-Hsuan Chen

    Inventor： Huan-Chang LIN ,  Hsin-Hung LIN ,  Cai-Yu KAO ,  Alice L. Yu ,  Wen-Ping PENG ,  Chung-Hsuan Chen

    IPC: C12Q1/70 ,  C12Q1/02 ,  C12Q1/68

    CPC classification number: G01N33/5091 ,  G01N33/5008 ,  G01N33/569 ,  G01N33/6848

    Abstract: Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.

    Abstract translation: 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。

    Transportation mechanism of magnetic handling for accessing compact disks
    4.
    发明授权
    Transportation mechanism of magnetic handling for accessing compact disks 失效
    用于访问光盘的磁性处理的运输机制

    公开(公告)号：US06405857B1

    公开(公告)日：2002-06-18

    申请号：US09690764

    申请日：2000-10-18

    Applicant: Jyh-Ming Wu ,  Yu-Pan Pai ,  Huan Chang Lin

    Inventor： Jyh-Ming Wu ,  Yu-Pan Pai ,  Huan Chang Lin

    IPC: B65G1558

    CPC classification number: B65G59/005 ,  B65G47/92 ,  B65G59/045

    Abstract: A transportation mechanism of magnetic handling for accessing Compact Disks. The transportation mechanism includes a reciprocating device having a base, an electromagnetic head provided on the base, a control unit controlling the reciprocating device such that the base is reciprocated between different processing positions, and a magnetic spacer. The Compact Disk, sandwiched by the electromagnetic head and the magnetic spacer as the magnetic spacer is attracted by the electromagnetic head, is further transported by the transportation mechanism whereby the damage due to bad suction for CDs is minimized. Comparing with the conventional suction means by vacuum, the transportation mechanism of the invention is also advantaged for the simple structure, easy maintenance, and low cost, thereby raising the production yield.

    Abstract translation: 用于访问紧凑型磁盘的磁性处理运输机制。 传送机构包括具有基座的往复运动装置，设置在基座上的电磁头，控制往复运动装置的控制单元，使得基座在不同的加工位置之间往复运动，而磁隔离件。 由电磁头和作为磁性间隔物的磁性隔片夹住的紧凑盘被电磁头吸引，由输送机构进一步输送，由此CD的不良吸引造成的损伤最小化。 与传统的抽吸装置相比，本发明的传送机构结构简单，维护方便，成本低，从而提高了生产成本。

    Optical recording medium protection cassette
    6.
    发明授权
    Optical recording medium protection cassette 失效
    光记录介质保护盒

    公开(公告)号：US06901601B1

    公开(公告)日：2005-05-31

    申请号：US09489791

    申请日：2000-01-24

    Applicant: Chun Han Wu ,  Huan Chang Lin

    Inventor： Chun Han Wu ,  Huan Chang Lin

    IPC: G11B23/00 ,  G11B23/03

    CPC classification number: G11B23/0316

    Abstract: The optical recording medium protection cassette of the present invention comprises a housing, a clasping member and at least one switch member. A first opening for retaining an optical recording medium is formed on a first lateral side of the housing and a groove is formed on the inside of a second lateral side which is perpendicular to the first lateral side. The clasping member is in engagement with the first opening of the housing to restrict the optical recording medium to be located within the housing. The clasping member is provided with at least a first buckling portion and at least a V-shaped portion having a first side and a second side. Each switch member has a first end as a second buckling portion fastened to the first buckling portion of the clasping member, which makes the switch member rotate relative to the first buckling portion, and a second end which is a positioning portion substantially stops at either the first side or the second side of the V-shaped portion.Furthermore, a clip member is formed at the clasping member, which has a protruding portion to fasten the groove disposed at the inside of the second lateral side of the housing so as to secure the clasping member within the housing, and an annular portion, the protruding portion of the clip member being disengaged from the groove such that the clasping member can be withdrawn from the housing by switching the annular portion.

    Abstract translation: 本发明的光记录介质保护盒包括壳体，夹紧构件和至少一个开关构件。 用于保持光学记录介质的第一开口形成在壳体的第一侧面上，并且在垂直于第一侧面的第二横向侧的内侧上形成有凹槽。 夹紧构件与壳体的第一开口接合以限制光记录介质位于壳体内。 夹紧构件设置有至少第一弯曲部分和至少具有第一侧面和第二侧面的V形部分。 每个开关构件具有第一端部，该第一端部紧固到夹紧构件的第一弯曲部分，该第二弯曲部分使得开关构件相对于第一弯曲部分旋转，并且作为定位部分的第二端基本上停止在 V形部分的第一侧或第二侧。 此外，夹紧构件形成在夹紧构件上，该夹紧构件具有突出部分，以紧固设置在壳体的第二侧面的内侧的凹槽，以将夹紧构件固定在壳体内，并且环形部分， 夹子构件的突出部分与凹槽脱离啮合，从而通过切换环形部分可以将夹紧构件从壳体中取出。

    Disk magazine for accessing CD disks
    7.
    发明授权
    Disk magazine for accessing CD disks 失效
    磁盘杂志，用于访问CD磁盘

    公开(公告)号：US06435343B1

    公开(公告)日：2002-08-20

    申请号：US09685979

    申请日：2000-10-10

    Applicant: Jyh-Ming Wu ,  Yu-Pan Pai ,  Huan-Chang Lin

    Inventor： Jyh-Ming Wu ,  Yu-Pan Pai ,  Huan-Chang Lin

    IPC: B65D8557

    CPC classification number: G11B23/00 ,  G11B33/045

    Abstract: A disk magazine for accessing Compact Disks includes a bottom stage, a vertical shaft fixed and supported at the bottom stage, a prop-up piece being loaded with Compact Disks and having an opening through which the vertical shaft extends, a barrel tightly combined with the bottom stage at the lower end, and a lid tightly covering up the upper side of the bottom stage. The lid is provided with a fixing hole into which the tapering tip pole of the vertical shaft inserts, and two O-rings are used for sealing between the lid and barrel, as well as between the bottom stage and barrel respectively to prevent the disk magazine from the environmental contamination.

    Abstract translation: 用于访问紧凑型盘的磁盘盒包括底部，在底部固定和支撑的垂直轴，支撑件，其装载有紧凑盘，并具有垂直轴延伸的开口，紧紧地与 底部底部，盖子紧紧地覆盖底部的上侧。 盖设有一个固定孔，垂直轴的锥形尖端插入到该固定孔中，两个O形圈用于密封盖和桶之间以及底部和桶之间，以防止盘盒 从环境污染。

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